13,883 research outputs found
Bilayered scaffold with 3D printed stiff subchondral bony compartment to provide constant mechanical support for long-term cartilage regeneration
BACKGROUND/OBJECTIVE: We seek to figure out the effect of stable and powerful mechanical microenvironment provided by Ti alloy as a part of subchondral bone scaffold on long-term cartilage regeneration. METHODS: we developed a bilayered osteochondral scaffold based on the assumption that a stiff subchondral bony compartment would provide stable mechanical support for cartilage regeneration and enhance subchondral bone regeneration. The subchondral bony compartment was prepared from 3D printed Ti alloy, and the cartilage compartment was created from a freeze-dried collagen sponge, which was reinforced by poly-lactic-co-glycolic acid (PLGA). RESULTS: In vitro evaluations confirmed the biocompatibility of the scaffold materials, while in vivo evaluations demonstrated that the mechanical support provided by 3D printed Ti alloy layer plays an important role in the long-term regeneration of cartilage by accelerating osteochondral formation and its integration with the adjacent host tissue in osteochondral defect model at rabbit femoral trochlea after 24 weeks. CONCLUSION: Mechanical support provided by 3D printing Ti alloy promotes cartilage regeneration by promoting subchondral bone regeneration and providing mechanical support platform for cartilage synergistically. TRANSITIONAL POTENTIAL STATEMENT: The raw materials used in our double-layer osteochondral scaffolds are all FDA approved materials for clinical use. 3D printed titanium alloy scaffolds can promote bone regeneration and provide mechanical support for cartilage regeneration, which is very suitable for clinical scenes of osteochondral defects. In fact, we are conducting clinical trials based on our scaffolds. We believe that in the near future, the scaffold we designed and developed can be formally applied in clinical practice
Measurement of the branching fractions of psi(2S) -> 3(pi+pi-) and J/psi -> 2(pi+pi-)
Using data samples collected at sqrt(s) = 3.686GeV and 3.650GeV by the BESII
detector at the BEPC, the branching fraction of psi(2S) -> 3(pi+pi-) is
measured to be [4.83 +- 0.38(stat) +- 0.69(syst)] x 10^-4, and the relative
branching fraction of J/psi -> 2(pi+pi-) to that of J/psi -> mu+mu- is measured
to be [5.86 +- 0.19(stat) +- 0.39(syst)]% via psi(2S) -> (pi+pi-)J/psi, J/psi
-> 2(pi+pi-). The electromagnetic form factor of 3(pi+pi-) is determined to be
0.21 +- 0.02 and 0.20 +- 0.01 at sqrt(s) = 3.686GeV and 3.650GeV, respectively.Comment: 17pages, 7 figures, submitted to Phys. Rev.
Measurement of the chi_{c2} Polarization in psi(2S) to gamma chi_{c2}
The polarization of the chi_{c2} produced in psi(2S) decays into gamma
chi_{c2} is measured using a sample of 14*10^6 psi(2S) events collected by
BESII at the BEPC. A fit to the chi_{c2} production and decay angular
distributions in psi(2S) to gamma chi_{c2}, chi_{c2} to pi pi and KK yields
values x=A_1/A_0=2.08+/-0.44 and y=A_2/A_0=3.03 +/-0.66, with a correlation
rho=0.92 between them, where A_{0,1,2} are the chi_{c2} helicity amplitudes.
The measurement agrees with a pure E1 transition, and M2 and E3 contributions
do not differ significantly from zero.Comment: 6 pages, 4 figures, 1 tabl
Measurements of J/psi decays into phi pi^0, phi eta, and phi eta^prime
Based on 5.8x10^7 J/psi events detected in BESII, the branching fractions of
J/psi--> phi eta and phi eta^prime are measured for different eta and eta^prime
decay modes. The results are significantly higher than previous measurements.
An upper limit on B(J/psi--> phi pi^0) is also obtained.Comment: 9 pages, 10 figure
Observation of p pbar pi^0 and p pbar eta in psi' decays
The processes psi'-->p pbar pi^0 and psi'-->p pbar eta are studied using a
sample of 14 million psi' decays collected with the Beijing Spectrometer at the
Beijing Electron-Positron Collider. The branching fraction of psi'-->p pbar
pi^0 is measured with improved precision as (13.2\pm 1.0\pm 1.5)\times 10^{-5},
and psi'-->p pbar eta is observed for the first time with a branching fraction
of (5.8\pm 1.1\pm 0.7)\times 10^{-5}, where the first errors are statistical
and the second ones are systematic.Comment: 15 pages, 8 figures and 3 table
Single-cell RNA-seq reveals fate determination control of an individual fiber cell initiation in cotton (Gossypium hirsutum)
Cotton fiber is a unicellular seed trichome, and lint fiber initials per seed as a factor determines fiber yield. However, the mechanisms controlling fiber initiation from ovule epidermis are not understood well enough. Here, with single-cell RNA sequencing (scRNA-seq), a total of 14,535 cells were identified from cotton ovule outer integument of Xu142_LF line at four developmental stages (1.5, 1, 0.5 days before anthesis and the day of anthesis). Three major cell types, fiber, non-fiber epidermis and outer pigment layer were identified and then verified by RNA in situ hybridization. A comparative analysis on scRNA-seq data between Xu142 and its fiberless mutant Xu142 fl further confirmed fiber cluster definition. The developmental trajectory of fiber cell was reconstructed, and fiber cell was identified differentiated at 1 day before anthesis. Gene regulatory networks at four stages revealed the spatiotemporal pattern of core transcription factors, and MYB25-like and HOX3 were demonstrated played key roles as commanders in fiber differentiation and tip-biased diffuse growth, respectively. A model for early development of a single fiber cell was proposed here, which sheds light on further deciphering mechanism of plant trichome and the improvement of cotton fiber yield
Search for psi(3770)\ra\rho\pi at the BESII detector at the Beijing Electron-Positron Collider
Non- decay \psppto \rhopi is searched for using a data sample of
taken at the center-of-mass energy of 3.773 GeV by the
BESII detector at the BEPC. No \rhopi signal is observed, and the upper limit
of the cross section is measured to be \sigma(\EETO \rhopi)<6.0 pb at 90% C.
L. Considering the interference between the continuum amplitude and the \pspp
resonance amplitude, the branching fraction of \pspp decays to is
determined to be \BR(\pspp\ra\rho\pi)\in(6.0\times10^{-6}, 2.4\times10^{-3})
at 90% C. L. This is in agreement with the prediction of the - and -wave
mixing scheme of the charmonium states for solving the ``\rhopi puzzle''
between \jpsi and \psp decays.Comment: 15 pages, 5 figure
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