Vocal fold composition and early glottic carcinoma infiltration

<p>Abstract</p> <p>Background</p> <p>Current imaging techniques provide only limited information pertaining to the extent of infiltration of laryngeal carcinomas into vocal fold tissue layers. Therefore, it is needed to seek the contribute to the body of knowledge surrounding examination and characterization in laryngeal carcinoma infiltration.</p> <p>Methods</p> <p>Excised larynges were collected from 30 male laryngectomy patients with an average age of 43.5 years (ranging 36 to 55 years) and history of smoking (≥10 years) exhibiting T1, T2, or subglottal (normal vocal fold) carcinomas. Vocal folds were preserved via freezing or immersion in paraffin. The depth of the mucosa, submucosa, and muscular layers in both normal vocal folds and tumor tissues of afflicted vocal folds was measured.</p> <p>Results</p> <p>The average depths of the mucosa, submucosa, and muscular layers in normal vocal folds were 0.15 ± 0.06 mm, 2.30 ± 0.59 mm, and 2.87 ± 0.88 mm, respectively. Infiltration measurements of T1 tumors showed a depth of 1.62 ± 0.51 mm and 1.32 ± 0.49 mm in frozen sections and paraffin-embedded samples, respectively. Similarly, T2 tumors showed a depth of 2.87 ± 0.68 mm and 2.58 ± 0.67 mm in frozen sections and paraffin-embedded samples, respectively. T1 and T2 tumors occupied 24.8 ± 10 and 48.5 ± 15 percent of the normal vocal fold depth, respectively.</p> <p>Conclusion</p> <p>This data provides a baseline for estimating infiltration of laryngeal carcinomas in vocal fold tissue layers, of particular interest to surgeons. This information may be used to assess typical depths of infiltration, thus allowing for more appropriate selection of surgical procedures based on individual patient assessment.</p

Effect of a Baffle on Bubble Distribution in a Bubbling Fluidized Bed

In this study, the multi-phase Eulerian–Eulerian two-fluid method (TFM) coupled with the kinetic theory of granular flow (KTGF) was used to investigate the hydrodynamics of particle flows (Geldart Group B) in a lab-scale bubbling fluidized bed. The goal was to improve the bubble flow behavior inside the fluidized bed to improve the distribution of an injected liquid, by increasing the flow of bubbles entering the spray jet cavity and, thus, reduce the formation of wet agglomerates. The effects of a baffle on both the injection level and the whole fluidized bed were studied. Different baffle geometries were also investigated. Adding a fluxtube to a baffle can improve the bubble flows and a long fluxtube works best at redirecting gas bubbles. Baffles tend to smooth out variations in the gas distribution caused by the non-uniform inlet gas distribution. A gas pocket appears under all the baffles

Study of Turbulence Promoters in Prolonging Membrane Life

Nanofiltration membrane technology is an effective method for secondary treated sewage purification. However, membrane fouling, which is inevitable in the membrane-separation process, can reduce membrane performance and shorten membrane life. Installing a turbulence promoter is a promising means of improving the hydraulic conditions inside the membrane chamber. In this study, the effect of turbulence promoter on prolonging membrane life was studied for the first time. Flat-sheet polyethersulfone nanofiltration membrane was used to filter humic acid solution, used for simulating secondary treated sewage. By comparing photographs and SEM images of the membrane before and after the simulated secondary treated sewage filtration, it was found that humic acid tended to be deposited on the low-velocity region, which was reflected by COMSOL simulation. After incorporating a turbulence promoter, the reduction of the humic acid deposition area and membrane fouling resistance indicated that the turbulence promoter could reduce membrane fouling due to the improved hydraulic conditions. Additionally, the turbulence promoter also increased the flux and reduced the flux decay rate. The turbulence promoter was then place in the crossflow flat-sheet membrane filtration module, and the variation of flux with time was tested in simulated secondary treated sewage with different concentrations. The results showed that the membrane life for the filtration of simulated secondary treated sewage comprising 50, 250, and 500 ppm humic acid increased by 23.1%, 80.4%, and 85.7%, respectively. The results of this article can serve as a reference for the prediction of membrane life and the performance enhancement mechanism of membranes containing a turbulence promoter

MiR-539 inhibited the malignant behaviors of breast cancer cells by targeting SP1

The aberrant expression of microRNAs (miRNAs) is involved in the initiation and progression of human cancers. In our study, we found that miR-539 was down-regulated in breast cancer tissues and cell lines. Decreased expression of miR-539 was significantly associated with lymph node metastasis in patients with breast cancer. Overexpression of miR-539 inhibited the proliferation and promoted apoptosis of breast cancer cells. Moreover, highly expressed miR-539 significantly suppressed the epithelial–mesenchymal transition (EMT) and sensitized cells to cisplatin treatment. Mechanistically, miR-539 was found to target the specificity protein 1 (SP1) and down-regulated the expression of SP1 in breast cancer cells. Knockdown of miR-539 consistently increased the expression of SP1. The expression of miR-539 in breast cancer tissues was negatively correlated with the expression of SP1. Restoration of SP1 significantly attenuated the inhibitory effect of miR-539 on the proliferation of breast cancer cells. Taken together, our results indicate that miR-539 has a tumor suppressive role in breast cancer via targeting SP1, suggesting miR-539 as a promising target for the diagnosis of breast cancer.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author

ZnO-layered double hydroxide@graphitic carbon nitride composite for consecutive adsorption and photodegradation of dyes under UV and visible lights

In this work, a ZnO-layered double hydroxide@graphitic carbon nitride composite (ZnO-LDH@C3N4) was synthesized via co-precipitation method with solvothermal treatment. The structure and morphology of ZnO-LDH@C3N4 composite were characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopes/transmission electron microscopes (SEM/TEM), N-2 adsorption/desorption, ultraviolet visible diffuse reflectance spectroscopy (UV-Vis-DRS), photoluminescence spectrometer (PL) and electrochemical impedance spectroscopy (EIS). The adsorption and photocatalytic properties of ZnO-LDH@C3N4 composite towards the organic dyes: Orange II sodium salt (OrgII, an anionic azo dye) and methylene blue (MB, a cationic azo dye) were investigated. Compared to ZnO-LDH and g-C3N4, the ZnO-LDH@C3N4 composite displayed an excellent performance in both adsorption and photocatalytic degradation of the organic dyes. Moreover, a combination of ZnO-LDH and g-C3N4 significantly improved the photocatalytic performance of ZnO-LDH and g-C3N4 under visible-light irradiation. The adsorption and photocatalytic mechanism were also investigated

Robust and Durable Superhydrophobic Polyurethane Sponge for Oil/Water Separation

With the purpose of purging and recycling oil and organic solvent from a water surface, a superhydrophobic polyurethane (PU) sponge was fabricated through a combined method of interfacial polymerization (IP) and molecular self-assembly. The as-prepared sponge has a superwetting characteristic of superlipophilicity in atmosphere and superhydrophobicity both in atmosphere and under oil, and it can quickly and selectively absorb various kinds of oils up to 29.9 times its own weight. More importantly, because of a covalent combination of the sponge skeleton and the polyamide thin film from IP, the superhydrophobic sponges could be reused for oil/water separation over 500 cycles without losing its superhydrophobicity, showing the highest reusability among the reported absorptive materials. The superhydrophobic sponge also can be used in the continuous absorption and expulsion of oils and organic solvents from water surfaces with the help of a vacuum pump. All of these features make the sponge a promising candidate material for oil-spill cleanups

Robust and Durable Superhydrophobic Polyurethane Sponge for Oil/Water Separation

With the purpose of purging and recycling oil and organic solvent from a water surface, a superhydrophobic polyurethane (PU) sponge was fabricated through a combined method of interfacial polymerization (IP) and molecular self-assembly. The as-prepared sponge has a superwetting characteristic of superlipophilicity in atmosphere and superhydrophobicity both in atmosphere and under oil, and it can quickly and selectively absorb various kinds of oils up to 29.9 times its own weight. More importantly, because of a covalent combination of the sponge skeleton and the polyamide thin film from IP, the superhydrophobic sponges could be reused for oil/water separation over 500 cycles without losing its superhydrophobicity, showing the highest reusability among the reported absorptive materials. The superhydrophobic sponge also can be used in the continuous absorption and expulsion of oils and organic solvents from water surfaces with the help of a vacuum pump. All of these features make the sponge a promising candidate material for oil-spill cleanups