1,280 research outputs found
Advanced Boost System Developing for High EGR Applications
To support industry efforts of clean and efficient internal combustion engine development for passenger and commercial applications ⢠This program focuses on turbocharger improvement for medium and light duty diesel applications, from complete system optimization percepective to enable commercialization of advanced diesel combustion technologies, such as HCCI/LTC. ⢠Improve combined turbocharger efficiency up to 10% or fuel economy by 3% on FTP cycle at Tier II Bin 5 emission level
Animation of Human Locomotion Using Sagittal Elevation Angles
This paper presents a data-driven procedural model for the kinematic animation of human walking. The use of data yields realistic looking gait, while the procedural model yields flexibility. We present a new motion data representation, the sagittal elevation angles, and present biomechanical evidence that these angles have a stereotyped pattern across many different walking situations, implying their reusability as a motion data source. We also sketch our algorithm for animating human gait based on sagittal elevation angle data which allows us to generate curved locomotion on uneven terrain with stylistic variation without requiring new datasets
A molecular simulation analysis of producing monatomic carbon chains by stretching ultranarrow graphene nanoribbons
Atomistic simulations were utilized to develop fundamental insights regarding
the elongation process starting from ultranarrow graphene nanoribbons (GNRs)
and resulting in monatomic carbon chains (MACCs). There are three key findings.
First, we demonstrate that complete, elongated, and stable MACCs with fracture
strains exceeding 100% can be formed from both ultranarrow armchair and zigzag
GNRs. Second, we demonstrate that the deformation processes leading to the
MACCs have strong chirality dependence. Specifically, armchair GNRs first form
DNA-like chains, then develop into monatomic chains by passing through an
intermediate configuration in which monatomic chain sections are separated by
two-atom attachments. In contrast, zigzag GNRs form rope-ladder-like chains
through a process in which the carbon hexagons are first elongated into
rectangles; these rectangles eventually coalesce into monatomic chains through
a novel triangle-pentagon deformation structure under further tensile
deformation. Finally, we show that the width of GNRs plays an important role in
the formation of MACCs, and that the ultranarrow GNRs facilitate the formation
of full MACCs. The present work should be of considerable interest due to the
experimentally demonstrated feasibility of using narrow GNRs to fabricate novel
nanoelectronic components based upon monatomic chains of carbon atoms.Comment: 11 pages, 6 figures, Nanotechnology accepted versio
Qigong for the Management of Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2MD) is a complex, chronic, metabolic disease with hyperglycemia arising from insulin resistance, progressive pancreatic beta cell failure, insufficient insulin secretion and increased hepatic glucose output. In the Chinese medicine theory, T2DM is often referred to as a form of Xiao Ke (ćść¸´) or âwastingâthirst disorder.â Genetic, dietary, lifestyle and environmental factors play a role in T2DM. People with a family history of diabetes or who are obese are at the highest risk of developing the disease. T2DM is often associated with hypertension, dyslipidemia and atherosclerosis and if not managed can lead to complications including cerebrovascular accident, peripheral vascular disease and nephropathy. T2DM can be well managed with biomedical and Chinese medicine treatment approaches. Lifestyle changes including appropriate diet and exercise are paramount in managing T2DM. Regular Qigong practice can be a beneficial part of one\u27s exercise routine for T2DM selfâcare. Qigong exercise has shown promising results in clinical experience and in randomized, controlled pilot studies for affecting aspects of T2DM including positive associations between participation in Qigong and blood glucose, triglycerides, total cholesterol, weight, BMI and insulin resistance. This chapter looks at how traditional Chinese medicine (TCM) views diabetes as well as new understandings of how Qigong can support the management of T2DM
Cyclogram Planarity is Preserved in Upward Slope Walking
In a recent paper [1] Borghese et al., demonstrated that 4D pelvis-thigh-shank-foot cyclograms of human locomotion are surprisingly planar, if the segmental elevation angles rather than the traditional inter-segmental angles are used. In this work, we demonstrate that the planarity of elevation angle cyclograms is preserved even for slope walking, within a 15 degree range
q-deformed Dirac Monopole With Arbitrary Charge
We construct the deformed Dirac monopole on the quantum sphere for arbitrary
charge using two different methods and show that it is a quantum principal
bundle in the sense of Brzezinski and Majid. We also give a connection and
calculate the analog of its Chern number by integrating the curvature over
.Comment: Technical modifications made on the definition of the base. A more
geometrical trivialization is used in section
Squid giant axon contains neurofilament protein mRNA but does not synthesize neurofilament proteins
Author Posting. Š The Author(s), 2016. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Cellular and Molecular Neurobiology 37 (2017): 475-486, doi:10.1007/s10571-016-0382-z.When isolated squid giant axons are incubated in radioactive amino acids, abundant newly synthesized proteins are found in the axoplasm. These proteins are translated in the adaxonal Schwann cells and subsequently transferred into the giant axon. The question as to whether any de novo protein synthesis occurs in the giant axon itself is difficult to resolve because the small contribution of the proteins possibly synthesized intra-axonally is not easily distinguished from the large amounts of the proteins being supplied from the Schwann cells. In this paper we reexamine this issue by studying the synthesis of endogenous neurofilament (NF) proteins in the axon. Our laboratory previously showed that NF mRNA and protein is present in the squid giant axon, but not in the surrounding adaxonal glia. Therefore, if the isolated squid axon could be shown to contain newly synthesized NF protein de novo, it could not arise from the adaxonal glia. The results of experiments in this paper show that abundant 3H-labeled NF protein is synthesized in the squid giant fiber lobe containing the giant axonâs neuronal cell bodies, but despite the presence of NF mRNA in the giant axon, no labeled NF protein is detected in the giant axon. This lends support to the Glia-Axon Protein Transfer Hypothesis which posits that the squid giant axon obtains newly synthesized protein by Schwann cell transfer and not through intra-axonal protein synthesis, and further suggests that the NF mRNA in the axon is in a translationally repressed state.This research was supported by the Intramural Research Program of the NIH2017-05-2
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Challenges and Opportunities to Updating Prescribing Information for Longstanding Oncology Drugs.
A number of important drugs used to treat cancer-many of which serve as the backbone of modern chemotherapy regimens-have outdated prescribing information in their drug labeling. The Food and Drug Administration is undertaking a pilot project to develop a process and criteria for updating prescribing information for longstanding oncology drugs, based on the breadth of knowledge the cancer community has accumulated with the use of these drugs over time. This article highlights a number of considerations for labeling updates, including selecting priorities for updating; data sources and evidentiary criteria; as well as the risks, challenges, and opportunities for iterative review to ensure prescribing information for oncology drugs remains relevant to current clinical practice
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