Expanding Australia\u27s defence capabilities for technological asymmetric advantage in information, cyber and space in the context of accelerating regional military modernisation: A systemic design approach

Introduction. The aim of the project was to conduct a systemic design study to evaluate Australia\u27sopportunities and barriers for achieving a technological advantage in light of regional military technological advancement. It focussed on the three domains of (1) cybersecurity technology, (2) information technology, and (3) space technology. Research process. Employing a systemic design approach, the study first leveraged scientometric analysis, utilising informetric mapping software (VOSviewer) to evaluate emerging trends and their implications on defence capabilities. This approach facilitated a broader understanding of the interdisciplinary nature of defence technologies, identifying key areas for further exploration. The subsequent survey study, engaging 828 professionals across STEM, space, aerospace, defence/ law enforcement, and ICT, aimed to assess the impact, deployment likelihood, and developmental timelines of the identified technologies. Finally, five experts were interviewed to help elaborate on the findings in the survey and translate them into implications for the ADF. Findings. Key findings revealed significant overlaps in technology clusters, highlighting ten specific technologies or trends as potential force multipliers for the ADF. Among these, cybersecurity of critical infrastructure and optimisation and other algorithmic technologies were recognised for their immediate potential and urgency, suggesting a prioritisation for development investment. The analysis presented a clear imperative for urgent and prioritised technological investments, specifically in cybersecurity and information technologies, followed by space technologies. The research also suggested partnerships that Australia should develop to keep ahead in terms of regional military modernisation. Implications. To maintain a competitive edge, there is an urgent need for investment in the development and application of these technologies, as nearly all disruptive technologies identified for their potential impact, deployment/utilization likelihood, extensive use, and novelty for defence purposes are needed in the near-term (less than 5 years – cybersecurity and information technologies) or medium-term (less than 10 years – space technologies). In line with this, technology investments should be prioritized as follows: Priority 1 includes Cyber Security of critical infrastructure and optimization algorithms; Priority 2 encompasses Unmanned and autonomous systems and weapons, Deep/Machine Learning, and Space-based command and communications systems; and Priority 3 involves Industry 4.0 technologies, Quantum technology, Electromagnetic and navigation warfare systems, Hypersonic weapons, and Directed energy weapons. At the policy level, underfunding, bureaucratic inertia and outdated procurement models needed to be addressed to enhance agility of innovation. More critically, Australia needed to come up with creative ways to recruit, train and retain human capital to develop, manage and use these sophisticated technologies. Finally, in order to maintain a lead over competitors (China, Russia, Iran, North Korea) in the regional military technology competition, the survey and interviews indicate that Australia should continue its military technology alliances with long-standing partners (US, Europe, Israel), broaden its collaborations with more recent partners (Japan, Singapore, South Korea), and establish partnerships with new ones (India, Malaysia, Vietnam, Pacific Island nations). Conclusion. This study sheds light on the future direction for the ADF and Defence in general, underscoring the importance of strategic investments in up-and-coming technologies. By pinpointing strategic voids, potential partnerships, and sovereign technologies with high potential, this report acts as a roadmap for bolstering Australia’s defence capabilities and safeguarding its strategic interests amidst regional technological changes

The safety profile of a cationic lipid-mediated cystic fibrosis gene transfer agent following repeated monthly aerosol administration to sheep

Clinically effective gene therapy for Cystic Fibrosis has been a goal for over 20 years. A plasmid vector (pGM169) that generates persistent expression and reduced host inflammatory responses in mice has raised prospects for translation to the clinic. The UK CF Gene Therapy Consortium is currently evaluating long-term repeated delivery of pGM169 complexed with the cationic lipid GL67A in a large Multidose Trial. This regulatory-compliant evaluation of aerosol administration of nine doses of pGM169/GL67A at monthly intervals, to the sheep lung, was performed in preparation for the Multidose Trial. All sheep tolerated treatment well with no adverse effects on haematology, serum chemistry, lung function or histopathology. Acute responses were observed in relation to bronchoalveolar cellularity comprising increased neutrophils and macrophage numbers 1 day post-delivery but these increases were transient and returned to baseline. Importantly there was no cumulative inflammatory effect or lung remodelling with successive doses. Molecular analysis confirmed delivery of pGM169 DNA to the airways and pGM169-specific mRNA was detected in bronchial brushing samples at day 1 following doses 1, 5 and 9. In conclusion, nine doses of pGM169/GL67A were well tolerated with no significant evidence of toxicity that would preclude adoption of a similar strategy in CF patients

The Surface Array planned for IceCube-Gen2

IceCube-Gen2, the extension of the IceCube Neutrino Observatory, will feature three main components: an optical array in the deep ice, a large-scale radio array in the shallow ice and firn, and a surface detector above the optical array. Thus, IceCube-Gen2 will not only be an excellent detector for PeV neutrinos, but also constitutes a unique setup for the measurement of cosmic-ray air showers, where the electromagnetic component and low-energy muons are measured at the surface and high-energy muons are measured in the ice. As for ongoing enhancement of IceCube’s current surface array, IceTop, we foresee a combination of elevated scintillation and radio detectors for the Gen2 surface array, aiming at high measurement accuracy for air showers. The science goals are manifold: The in-situ measurement of the cosmic-ray flux and mass composition, as well as more thorough tests of hadronic interaction models, will improve the understanding of muons and atmospheric neutrinos detected in the ice, in particular, regarding prompt muons. Moreover, the surface array provides a cosmic-ray veto for the in-ice detector and contributes to the calibration of the optical and radio arrays. Last but not least, the surface array will make major contributions to cosmic-ray science in the energy range of the transition from Galactic to extragalactic sources. The increased sensitivities for photons and for cosmic-ray anisotropies at multi-PeV energies provide a chance to solve the puzzle of the origin of the most energetic Galactic cosmic rays and will serve IceCube’s multimessenger mission