Guide to Stakeholder Groups for Great Basin Sagebrush Steppe Restoration

This guide is intended to provide information on active stakeholder interest groups focused on restoration of sagebrush ecosystems in the Great Basin region. It is based on a comprehensive search of internet websites, recently filed litigation records, previous interviews, and discussions with land managers in the region. The information contained in the guide is representative of the general environment in which restoration activities are conducted in the six states comprising the SageSTEP project, and is not meant to be an all-inclusive listing of groups. All efforts were made to identify groups most active and thus most pertinent to land managers and researchers in the region. There undoubtedly exist additional groups active on a more local level, which are equally as significant to restoration activities as those identified here. The guide, as developed, is intended to be particularly useful for those working in fuels treatments and NEPA issues

Classifying Risky-Drinking College Students: Another Look at the Two-Week Drinker-Type Categorization

Objective The present study examined the effectiveness of the 2-week period currently used in the categorization of heavy episodic drinking among college students. Two-week drinker-type labels included the following: nonbinge drinker, binge drinker, and frequent binge drinker. Method Three samples of college student drinkers (104 volunteers, 283 adjudicated students, and 238 freshmen male students) completed the 3-month Timeline Followback assessment of drinking. Drinking behavior during the last 2 weeks of the month before the study was compared with drinking behavior during the first 2 weeks of the same month to compare behavior and resulting labels during both 2-week periods. Results Inconsistencies existed in drinker-type labels during the first 2 weeks of the month and the last 2 weeks of the month for all three samples. Between 40% and 50% of participants in the three samples were classified as a different drinker type across the month. Nonbinge drinkers experienced a wide range of alcohol-related problems, and much variation existed among the frequent-binge-drinker label. Conclusions The results suggest that the current definition needs to be modified to accurately identify risky-drinking college students. Expanding the assessment window past 2 weeks of behavior, as well as developing different classification schemes, might categorize risky drinkers more accurately

ECE Teachers' Perceptions of Evidence-Based PD and Intensive Coaching

Poster Division: Education and Human Ecology: 2nd Place (The Ohio State University Edward F. Hayes Graduate Research Forum)The instruction children receive from their early childcare and education (ECE) teachers through close relationships heavily impacts child learning and development, including emotional and social well-being, adaption to formal schooling, academic achievement, and overall life course trajectories (Brebner et al., 2015; Denham, 2006; Owen et al., 2008; Shonkoff & Phillips, 2000). Unfortunately, the training that influences these meaningful learning interactions is lacking. Many ECE teachers are without the proper educational training or professional development (PD) needed to foster these formative learning environments. Previous research has established coaching as a key factor of PD that enhances teachers' knowledge, skill, and education level, as well as assists with putting knowledge into practice (Kraft et al., 2018; Whitebook et al., 2018). These professional partnerships are most effective when strong, supportive relationships are formed between both actors (Artman-Meeker et al., 2015). To that effect, the purpose of this study was to examine ECE teachers' perceptions of a specialized PD training that combined evidence-based online modules with intensive coaching support. Distinguishing teachers' experiences of practice-based coaching can allow for the identification of key factors that support ECE teachers' learning and influence the instruction children receive within the early care setting. This study found that teachers held positive perceptions of intensive coaching after completing an online, evidenced-based professional development training. Our results offer suggestions for future research regarding the impact of coaching on teachers' professional development and educational influence on the growth and development of children.No embarg

Diagnostic Performance of Receptor-Specific Surgical Specimen Staining Correlates with Receptor Expression Level

Intraoperative margin assessment is imperative to cancer cure but is a continued challenge to successful surgery. Breast conserving surgery is a relevant example, where a cosmetically improved outcome is gained over mastectomy, but re-excision is required in \u3e25  %   of cases due to positive or closely involved margins. Clinical translation of margin assessment modalities that must directly contact the patient or required administered contrast agents are time consuming and costly to move from bench to bedside. Tumor resections provide a unique surgical opportunity to deploy margin assessment technologies including contrast agents on the resected tissues, substantially shortening the path to the clinic. However, staining of resected tissues is plagued by nonspecific uptake. A ratiometric imaging approach where matched targeted and untargeted probes are used for staining has demonstrated substantially improved biomarker quantification over staining with conventional targeted contrast agents alone. Our group has developed an antibody-based ratiometric imaging technology using fluorescently labeled, spectrally distinct targeted and untargeted antibody probes termed dual-stain difference specimen imaging (DDSI). Herein, the targeted biomarker expression level and pattern are evaluated for their effects on DDSI diagnostic potential. Epidermal growth factor receptor expression level was correlated to DDSI diagnostic potential, which was found to be robust to spatial pattern expression variation. These results highlight the utility of DDSI for accurate margin assessment of freshly resected tumor specimens

A Randomized Motivational Enhancement Prevention Group Reduces Drinking and Alcohol Consequences in First-Year College Women

Alcohol consumption among college students has become an increasing problem that requires attention from college administrators, staff, and researchers. Despite the physiological differences between men and women, college women are drinking at increasingly risky rates, placing them at increased risk for negative consequences. The current study tested a group motivational enhancement approach to the prevention of heavy drinking among 1st-year college women. Using a randomized design, the authors assigned participants either to a group that received a single-session motivational enhancement intervention to reduce risky drinking that focused partly on women’s specific reasons for drinking (n =126) or to an assessment-only control group (n =94). Results indicated that, relative to the control group participants, intervention participants drank fewer drinks per week, drank fewer drinks at peak consumption events, and had fewer alcohol-related consequences over a 10-week follow-up. Further, the intervention, which targeted women’s reasons for drinking, was more effective in reducing consumption for participants with high social and enhancement motivations for drinking

Characteristics of historical precipitation in high mountain asia based on a 15-year high resolution dynamical downscaling

The mountains of High Mountain Asia serve as an important source of water for roughly one billion people living downstream. This research uses 15 years of dynamically downscaled precipitation produced by the Weather Research and Forecasting (WRF) model to delineate contrasts in precipitation characteristics and events between regions dominated by the Indian Summer Monsoon (ISM) versus westerly disturbances during the cool season (December to March). Cluster analysis reveals a more complex spatial pattern than indicated by some previous studies and illustrates the increasing importance of westerly disturbances at higher elevations. Although prior research suggests that a small number of westerly disturbances dominate precipitation in the western Himalaya and Karakoram, the WRF-downscaled precipitation is less dominated by infrequent large events. Integrated vapor transport (IVT) and precipitation are tightly coupled in both regions during the cool season, with precipitation maximizing for IVT from the south-southwest over the Karakoram and southeast-southwest over the western Himalaya. During the ISM, Karakoram precipitation is not strongly related to IVT direction, whereas over the western Himalaya, primary and secondary precipitation maxima occur for flow from the west-southwest and northwest, respectively. These differences in the drivers and timing of precipitation have implications for hydrology, glacier mass balance, snow accumulation, and their sensitivity to climate variability and change

Female College Drinking and the Social Learning Theory: An Examination of the Developmental Transition Period from High School to College

Problematic drinking among college students remains a national issue with large percentages of college students reporting heavy episodic or binge drinking (Wechsler, Dowdall, Davenport, & Castillo, 1995) and experiencing severe alcohol-related consequences ranging from poor academic performance, to sexual assault, vandalism, and even death (Hingson, Heeren, Winter, & Wechsler, 2005; Wechsler et al., 2002). According to the National Institute on Alcohol Abuse and Alcoholism (NIAAA, 2002), the first 6 weeks on a college campus are critical to first-year student success. However, during these first weeks many students initiate heavy drinking that may interfere with their ability to adapt to campus life, and patterns of drinking established during these first weeks persist throughout college (Schulenberg et al., 2001). Approximately one third of first-year students fail to enroll for their second year due to difficulties with the transition to college (Upcraft, 1995). Drinking may compromise successful negotiation of the transition into college and therefore jeopardize overall collegiate success. Therefore, the ability to identify specific students as they enter college who may develop problematic drinking patterns and related negative consequences would allow student affairs personnel to more effectively design and target risk-reduction programs and interventions

Optimizing Fresh Specimen Staining for Rapid Identification of Tumor Biomarkers During Surgery.

Rationale: Positive margin status due to incomplete removal of tumor tissue during breast conserving surgery (BCS) is a prevalent diagnosis usually requiring a second surgical procedure. These follow-up procedures increase the risk of morbidity and delay the use of adjuvant therapy; thus, significant efforts are underway to develop new intraoperative strategies for margin assessment to eliminate re-excision procedures. One strategy under development uses topical application of dual probe staining and a fluorescence imaging strategy termed dual probe difference specimen imaging (DDSI). DDSI uses a receptor-targeted fluorescent probe and an untargeted, spectrally-distinct fluorescent companion imaging agent topically applied to fresh resected specimens, where the fluorescence from each probe is imaged and a normalized difference image is computed to identify tumor-target distribution in the specimen margins. While previous reports suggested this approach is a promising new tool for surgical guidance, advancing the approach into the clinic requires methodical protocol optimization and further validation. Methods: In the present study, we used breast cancer xenografts and receiver operator characteristic (ROC) curve analysis to evaluate a wide range of staining and imaging parameters, and completed a prospective validation study on multiple tumor phenotypes with different target expression. Imaging fluorophore-probe pair, concentration, and incubation times were systematically optimized using n=6 tissue specimen replicates per staining condition. Resulting tumor vs. normal adipose tissue diagnostic performance were reported and staining patterns were validated via receptor specific immunohistochemistry colocalization. Optimal staining conditions were tested in receptor positive and receptor negative cohorts to confirm specificity. Results: The optimal staining conditions were found to be a one minute stain in a 200 nM probe solution (area under the curve (AUC) = 0.97), where the choice of fluorescent label combination did not significantly affect the diagnostic performance. Using an optimal threshold value determined from ROC curve analysis on a training data set, a prospective study on xenografts resulted in an AUC=0.95 for receptor positive tumors and an AUC = 0.50 for receptor negative (control) tumors, confirming the diagnostic performance of this novel imaging technique. Conclusions: DDSI provides a robust, molecularly specific imaging methodology for identifying tumor tissue over benign mammary adipose tissue. Using a dual probe imaging strategy, nonspecific accumulation of targeted probe was corrected for and tumor vs. normal tissue diagnostic potential was improved, circumventing difficulties with ex vivotissue specimen staining and allowing for rapid clinical translation of this promising technology for tumor margin detection during BCS procedures