Dependence on the probability of observing ILPs based on substrate type and number of ILPS relative to substrate burden visualized on the basis of co-registered EAM and CMR images (LGE and T2*).

<p>(<b>A</b>) Shows the overall incidence of ILPs (fraction of the total) that were coincident with regions containing iron (IRON+) and regions without iron (IRON−). (<b>B</b>) Shows the mean number of ILPs per volume of substrate, with the substrate being the total scar (i.e., scar with and without iron), scarred regions with iron (IRON+) and scarred regions without iron (IRON−).</p

Representative specific impedance spectra from Remote, IRON-, and IRON+ myocardial samples.

<p>Note that for a given AC frequency, the specific impedance of IRON+ samples is higher than that of the Remote and IRON− samples.</p

Relationship between Normalized Permittivity and Iron Content.

<p>Relationship between Normalized Permittivity and Iron Content.</p

Electrical consequences of iron deposition in ex-vivo myocardium.

<p>(<b>A</b>) Mean measured from Remote, IRON−, and IRON+ infarct sections showed significantly greater (*, p<0.001) in IRON+ compared to Remote and IRON− sections; (<b>B</b>) however, mean measured from Remote, IRON−, and IRON+ infarct sections did not show any statistical difference in between the different sections.</p

Mean values of important surface ECG parameters over day, night and a 24-hour period from Iron (>1.5%) and Iron (<1.5%) dogs.

<p>The mean values from dogs with and without iron over the period of interest for heart rate (<b>A</b>), QT (<b>B</b>), QTc (<b>C</b>) and QTcd (<b>D</b>) are shown.</p

24-hour Holter ECG recordings from Iron (>1.5%) and Iron (<1.5%) dogs.

<p>The mean 24-hour traces showing changes in heart rate (<b>A</b>), QT (<b>B</b>), QT corrected for heart rate (<b>C</b>), and QTc dispersion (<b>D</b>) are shown for the two different groups of dogs with and without iron deposition.</p

Representative co-registered CMR images and endocardial EAMs showing the association between ILPs and iron deposition following myocardial infarction.

<p>Co-registered late-gadolinium enhancement images projected onto the segmented blood pool surface (<b>A</b>) with infarcted territory (color coded in red), border zone (yellow and blue shades) and remote territories (purple)) with the corresponding bipolar map (<b>B</b>, color-coded to indicate low voltage areas) are shown. For reference, an ILP deep within the scar tissue (white arrow) is shown. The voltage traces from V1 and at the coronary sinus (CS), along with bipolar and unipolar mapping traces are also shown. Note the presence of an isolated low-voltage sharp late potential in the bipolar and unipolar traces following the local ventricular activation (yellow arrow) in <b>C</b>. The activation map (<b>D</b>), a map of the ILPs (<b>E</b>), and iron containing regions (in red, <b>F</b>) are also shown for reference. Note that iron-containing regions have a greater incidence of ILPs and slow activation regions.</p

Relation between scar features and chronic iron deposition.

<p>(<b>A</b>) Representative short-axis LGE and T2*-weighted (TE  = 6.5 ms) images from two canines subjected to MI from Group in vivo – one with chronic iron deposition within the scar territory (Iron (>1.5%)) and another without chronic iron deposition (Iron (<1.5%)) are shown. Red arrows point to the site of myocardial scar on the LGE images in both the cases and to chronic iron deposition on the T2*-weighted image. (<b>B</b>) A significant sigmoidal relation was found between scar volume and iron volume (both computed as a percentage of total LV myocardium; R² = 0.75, p <0.001).</p

Regional association plots for the two associated SNPs with SCD.

<p>Each SNP is plotted with respect to its chromosomal location (x-axis) and –log₁₀P-value (y-axis on the left). The spikes indicate the recombination rate (y-axis on the right) at that region of the chromosome.</p

Summary of the two loci associated with SCD.

<p>Chr, chromosome; SE, standard error; OR, odds ratio.</p