595 research outputs found
PHP82 Impact of Clinical and Health Economic Publications on Commercial success of Pharmaceutical products in the U.S
PMS48 Cost-Effectiveness of Tocilizumab for The Management of Inadequately Responding Rheumatoid Arthritis Patients
Weiner, LawrencePrimer pla de l'obra. Tres grans
paral·lelepĂpedes de formigĂł, amb
aparença de sarcĂČfags.Repartits al llarg
de l'avinguda. Tots porten uns versos,
escrits el 1845, quan tenia 15 anys, pel
premi Nobel Frederic Mistral
PMS74 Developing and Implementing Patient-Resource Use Diaries for a Clinical Trial Assessing Spinal Stenosis Interventions in the Elderly
Coordination Implications of Software Coupling in Open Source Projects
The effect of software coupling on the quality of software has been studied quite widely since the seminal paper on software modularity by Parnas [1]. However, the effect of the increase in software coupling on the coordination of the developers has not been researched as much. In commercial software development environments there normally are coordination mechanisms in place to manage the coordination requirements due to software dependencies. But, in the case of Open Source software such coordination mechanisms are harder to implement, as the developers tend to rely solely on electronic means of communication. Hence, an understanding of the changing coordination requirements is essential to the management of an Open Source project. In this paper we study the effect of changes in software coupling on the coordination requirements in a case study of a popular Open Source project called JBoss
The Mars Science Laboratory record of optical depth measurements via solar imaging
Acknowledgments We are grateful to the teams that developed, landed, and operated Curiosity on Mars, allowing for the present study. The research was conducted partly at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration (80NM0018D0004). MTL was supported via sub-contract 18-1187 from Malin Space Science Systems, Inc. SDG was supported by the MSL Participating Scientist program. JMB was supported by MSL Participating Scientist Grant 80NSSC22K0657. AV-R was supported by the Comunidad de Madrid Project S2018/NMT-4291 (TEC2SPACE-CM). M-PZ was supported by grant PID2019-104205GB-C21 funded by MCIN/AEI/10.13039/501100011033. JM-T was supported by UK Space Agency projects ST/W00190X/1 and ST/V00610X/1.Peer reviewedPostprin
Primary ciliary dyskinesia: Longitudinal study of lung disease by ultrastructure defect and genotype
Rationale: In primary ciliary dyskinesia, factors leading to disease heterogeneity are poorly understood. Objectives: To describe early lung disease progression in primary ciliary dyskinesia and identify associations between ultrastructural defects and genotypes with clinical phenotype. Methods: This was a prospective, longitudinal (5 yr), multicenter, observational study. Inclusion criteria were less than 19 years at enrollment and greater than or equal to two annual study visits. Linear mixed effects models including random slope and random intercept were used to evaluate longitudinal associations between the ciliary defect group (or genotype group) and clinical features (percent predicted FEV 1 and weight and height z-scores). Measurements and Main Results: A total of 137 participants completed 732 visits. The group with absent inner dynein arm, central apparatus defects, and microtubular disorganization (IDA/CA/MTD) (n = 41) were significantly younger at diagnosis and in mixed effects models had significantly lower percent predicted FEV 1 and weight and height z-scores than the isolated outer dynein arm defect (n = 55) group. Participants with CCDC39 or CCDC40 mutations (n = 34) had lower percent predicted FEV 1 and weight and height z-scores than those with DNAH5 mutations (n = 36). For the entire cohort, percent predicted FEV 1 decline was heterogeneous with a mean (SE) decline of 0.57 (0.25) percent predicted/yr. Rate of decline was different from zero only in the IDA/MTD/CA group (mean [SE], 21.11 [0.48] percent predicted/yr; P = 0.02). Conclusions: Participants with IDA/MTD/CA defects, which included individuals with CCDC39 or CCDC40 mutations, had worse lung function and growth indices compared with those with outer dynein arm defects and DNAH5 mutations, respectively. The only group with a significant lung function decline over time were participants with IDA/MTD/CA defects
Modified differentials and basic cohomology for Riemannian foliations
We define a new version of the exterior derivative on the basic forms of a
Riemannian foliation to obtain a new form of basic cohomology that satisfies
Poincar\'e duality in the transversally orientable case. We use this twisted
basic cohomology to show relationships between curvature, tautness, and
vanishing of the basic Euler characteristic and basic signature.Comment: 20 pages, references added, minor corrections mad
Cytoplasmic âciliary inclusionsâ in isolation are not sufficient for the diagnosis of primary ciliary dyskinesia
Background: The diagnosis of primary ciliary dyskinesia (PCD) is difficult and requires a combination of clinical features, nasal nitric oxide testing, cilia ultrastructural analysis by electron microscopy (EM), and genetics. A recently described cytoplasmic ultrastructural change termed âciliary inclusionsâ was reported to be diagnostic of PCD; however, no supporting evidence of PCD was provided. In this study, we sought to confirm, or refute, the diagnosis of PCD in subjects with âciliary inclusionsâ on EM. Methods: Six subjects from five families with previous lab reports of âciliary inclusionsâ on EMs of ciliated cells were identified and evaluated at a Genetic Disorders of Mucociliary Clearance Consortium site. We performed a detailed clinical history, nasal nitric oxide measurement, genetic testing including whole-exome sequencing (WES), and when possible, repeat ciliary EM study. Results: Only one of six subjects had multiple and persistent clinical features congruent with PCD. No subject had situs inversus. Only one of six subjects had a very low nasal nitric oxide level. No âciliary inclusionsâ were found in three subjects who had a repeat ciliary EM, and ciliary axonemal ultrastructures were normal. Genetic testing, including WES, was negative for PCD-causing genes, and for pathogenic variants in gene pathways that might cause âciliary inclusions,â such as ciliary biogenesis. Conclusion: âCiliary Inclusionsâ, in isolation, are not sufficient to diagnosis PCD. If seen, additional studies should be done to pursue an accurate diagnosis
Possible charge inhomogeneities in the CuO2 planes of YBa2Cu3O6+x (x=0.25, 0.45, 0.65, 0.94) from pulsed neutron diffraction
The atomic pair distribution functions (PDF) of four powder samples of
YBa2Cu3O6+x (x=0.25, 0.45, 0.65, 0.94) at 15 K have been measured by means of
pulsed neutron diffraction. The PDF is modelled using a full-profile fitting
approach to yield structural parameters. In contrast to earlier XAFS work we
find no evidence of a split apical oxygen site. However, a slightly improved
fit over the average crystallographic model results when the planar Cu(2) site
is split along the z-direction. This is interpreted in terms of charge
inhomogeneities in the CuO2 planes.Comment: 8 pages, 3 figure
Fully differential W' production and decay at next-to-leading order in QCD
We present the fully differential production and decay of a W' boson, with
arbitrary vector and axial-vector couplings, to any final state at
next-to-leading order in QCD. We demonstrate a complete factorization of
couplings at next-to-leading order in both the partial width of the W' boson,
and in the full two-to-two cross section. We provide numerical predictions for
the contribution of a W' boson to single-top-quark production, and separate
results based on whether the mass of the right-handed neutrino (nu_R) is light
enough for the leptonic decay channel to be open. The single-top-quark analysis
will allow for an improved direct W' mass limit of 525-550 GeV using data from
run I of the Fermilab Tevatron. We propose a modified tolerance method for
estimating parton distribution function uncertainties in cross sections.Comment: 23 pages, revtex3, 13 ps fig
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