<i>VIM</i> methylation in cfDNA.

<p>Cases from France (A) and Thailand (B), in tissue (C) (the arrows show the CpG-site analysed in TCGA data) and in TCGA data (D) (the grey area represents the area analyzed by massively parallel sequencing in this study). CTR: controls, HCC: hepatocellular carcinoma patients and CLD: chronic liver diseases. The error bars represent standard error of mean.</p

Mean methylation proportions and 95% confidence intervals for HCC cases by tumor stages.

<p>A, B and C (Barcelona Clinic Liver Cancer staging system) and controls from France.</p

<i>VIM</i> methylation in liver cell lines with different <i>TP53</i> mutation and HBV–status.

<p>WT = wild type, R249S = missense mutation in the codon 249 of TP53.</p

Geographic distribution of liver cancer cases.

<p>Dots represent the distribution by province. Pie charts describe the distribution of HCC/no cirrhosis (lines), HCC/cirrhosis (full black) and CC (small dots) among the Northwest, Northeast and Central-south parts of the country.</p

<i>FBLN1</i> methylation in cfDNA.

<p>Cases from France (A) and Thailand (B), in tissue (C) (the arrows show the CpG-site analysed in TCGA data) and in TCGA data (D) (the grey area represents the area analyzed by massively parallel sequencing in this study). CTR: controls, HCC: hepatocellular carcinoma patients and CLD: chronic liver diseases. The error bars represent standard error of mean.</p

Relation between Plasma <i>R249S-</i>mutated <i>DNA</i> and HBs-antigen (HBsAg) and HCV-antibody (HCV-ab).

<p><i>X₂</i> test when compared to cholangiocarcinoma, chronic liver disease and reference group all together (*: p value <0.05; ***: p value <0.001; NA: Not Available; ns: non significant).</p

Box and whisker distributions of <i>TP53 R249S</i>-<i>mutated DNA plasma concentrations</i> (≥150 copies/mL) for the different groups.

<p>Boxes extend from 25^th to 75^th percentiles and are divided by a solid line representing the median of each centre. The median levels for the different groups are: 328 in HCC/no cirrhosis, 273 in HCC/cirrhosis, 252 in CC, 256 in CLD and 202 in R.</p

Mean methylation proportions and 95% confidence intervals for <i>FBLN1</i> and <i>VIM</i> in France and in Thailand.

<p>HCC = hepatocellular carcinoma, CTR = control, CLD = chronic liver disease.</p

Relation between Plasma <i>R249S-mutated DNA</i> and AFP.

*<p><i>X₂</i> test comparing individuals with <i>R249S</i> > = 150 copies/mL against individuals with <i>R249S</i> <150 copies/mL.</p

Two independent association signals at the 1p11.2 locus: Association results for breast cancer risk among European women in BCAC, by tumor characteristic.

<p>Two independent association signals at the 1p11.2 locus: Association results for breast cancer risk among European women in BCAC, by tumor characteristic.</p