93 research outputs found

    PENERAPAN  TEKNIK BERKIRIM SALAM DAN SOAL UNTUK KETERAMPILAN BERBICARA BAHASA JERMAN SISWA KELAS XI MIPA I SMAN 3 SIDOARJO

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    Kata Kunci   : Teknik Berkirim Salam dan Soal, Keterampilan Berbicara, siswa kelas XI MIPA 1 SMAN 3 Sidoarjo.          Keterampilan berbicara adalah keterampilan yang terpenting dalam pembelajaran suatu bahasa. Untuk menguasai keterampilan berbicara ini guru membutuhkan teknik alternativ yaitu Teknik Berkirim Salam dan Soal. Teknik berkirim salam dan soal merupakan salah satu teknik dalam pembelajaran kooperatif. Dengan teknik ini siswa bisa melatih keterampilan berbicara mereka.          Rumusan masalah dalam penelitian ini adalah “ Bagaimana penerapan Teknik Berkirim Salam dan Soal untuk Keterampilan Berbicara Bahasa Jerman Siswa Kelas XI MIPA I sman 3 Sidoarjo?.” Tujuan penelitian ini adalah “ Untuk mengetahui bagaimana penerapan teknik berkirim salam dan soal untuk keterampilan berbicara siswa kelas XI MIPA SMAN 3 Sidoarjo. Jenis Penelitian ini adalah deskripstif kualitatif. Teknik pengumpulan data menggunakan observasi dan angket terhadap hasil kerja siswa.          Hasil penelitian menunjukkan bahwa siswa tidak takut berbicara dalam bahasa Jerman.Hasil observasi aktivitas siswa meningkat pada setiap pertemuan dengan presentas 65,6% pada pertemuan pertama, 46,9% pada pertemuan kedua,65,6% pada pertemuan ketiga dan 75% pada pertemuan keempat.. Sehingga dapat diketahui bahwa frekuensi aktivitas siswa yang muncul pada setiap pertemuan mengalami peningkatan. Pendapat para siswa tentang penerapan Teknik Berkirim Salam dan Soal juga positif dan menyenangkan, ditunjang dengan hasil tes berbicara memuaskan dan menunjang hasil angket

    Matrix Assisted Laser Desorption (MALDI), a versatile tool for the characterization of Dendrimers

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    Matrix Assisted Laser Desorption (MALDI) is a soft ionization technique used in modern day chemistry to analyze polymers with high precision and speed. This technique does not require any polymer standard for mass calibration (as in the case of gel – permeation chromatography GPC). Protocols require only minimum amounts of solvent and consumables. Measurements of the masses of individual oligomers facilitate the determination of masses of monomers and end groups. This overview discusses the application and use of MALDI for the determination of molecular mass distribution of oligomers and end groups. However, biomolecules and other polymers with a polydispersity index (PDI) greater than 1.2 are not suitable candidates for this analysis owing to signal intensity discrimination against higher mass oligomers

    Allogeneic chimerism with low-dose irradiation, antigen presensitization, and costimulator blockade in H-2 mismatched mice

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    We have previously shown that the keys to high-level nontoxic chimerism in syngeneic models are stem cell toxic, nonmyelotoxic host treatment as provided by 100-cGy whole-body irradiation and relatively high levels of marrow stem cells. This approach was unsuccessful in H-2 mismatched B6.SJL to BALB/c marrow transplants, but with tolerization, stable multilineage chimerism was obtained. Ten million B6.SJL spleen cells were infused intravenously into BALB/c hosts on day -10 and (MR-1) anti-CD40 ligand monoclonal antibody (mAb) injected intraperitoneally at varying levels on days -10, -7, -3, 0, and +3 and the BALB/c mice irradiated (100 cGy) and infused with 40 million B6.SJL/H-2 mismatched marrow cells on day 0. Stable multilineage chimerism at levels between 30% to 40% was achieved in the great majority of mice at 1.6 mg anti-CD40 ligand mAb per injection out to 64 weeks after transplantation, without graft-versus-host disease. The transplanted mice were also tolerant of donor B6.SJL, but not third-party CBA/J skin grafts at 8 to 9 and 39 to 43 weeks after marrow transplantation. These data provide a unique model for obtaining stable partial chimerism in H-2 mismatched mice, which can be applied to various clinical diseases of man such as sickle cell anemia, thalassemia, and autoimmune disorders

    グローバリゼーション カ ノ タイワン バイリンガル コッカ セイサク

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    批判的社会言語学の現在論

    タイワン ザイジュウ ガイコクジン ニ ムケタ タゲンゴ ヒョウジ タイチュウ トウキョウ ヒロバ ノ チョウサ カラ

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    批判的社会言語学の深

    Role of Rho Kinase in Microvascular Damage Following Cerebral Ischemia Reperfusion in Rats

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    Rho kinase (ROCK) is a well-known downstream effector of Rho and plays an important role in various physiopathological processes. In this study, we aim to investigate the correlation between ROCK and microvascular damage in rat brain subjected to middle cerebral artery occlusion (MCAO) and reperfusion, and to elucidate the mechanisms underlying the microvascular damage. ROCK and matrix metalloproteinase 9 (MMP9) mRNA levels were determined by real time quantitative PCR, Laminin was detected by immunofluorescence and Blood Brain Barrier (BBB) permeability was examined by Evans Blue (EB) in rat MCAO models. We observed similar patterns of changes in ROCK expression, brain EB content, and Laminin expression at different time points after brain ischemia. Statistical analysis further confirmed a significant linear correlation of ROCK expression with the onset of microvascular damage in brain. Furthermore, the ROCK inhibitor fasudil decreased brain EB content but increased Laminin expression. These results provide strong evidence that ROCK mediates microvascular damage. In addition, we found that fasudil could significantly inhibit MMP9 expression induced by ischemia. Thus, our findings suggest that ROCK promotes microvascular damage by upregulating MMP9 and reveal ROCK as a promising therapeutic target for stroke
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