98 research outputs found
Re-examination of chinese semantic processing and syntactic processing: Evidence from conventional ERPs and reconstructed ERPs by residue iteration decomposition (RIDE)
© 2015 Wang et al. A number of studies have explored the time course of Chinese semantic and syntactic processing. However, whether syntactic processing occurs earlier than semantics during Chinese sentence reading is still under debate. To further explore this issue, an event-related potentials (ERPs) experiment was conducted on 21 native Chinese speakers who read individually-presented Chinese simple sentences (NP1+VP+NP2) word-by-word for comprehension and made semantic plausibility judgments. The transitivity of the verbs was manipulated to form three types of stimuli: congruent sentences (CON), sentences with a semantically violated NP2 following a transitive verb (semantic violation, SEM), and sentences with a semantically violated NP2 following an intransitive verb (combined semantic and syntactic violation, SEM+SYN). The ERPs evoked from the target NP2 were analyzed by using the Residue Iteration Decomposition (RIDE) method to reconstruct the ERP waveform blurred by trial-to-trial variability, as well as by using the conventional ERP method based on stimulus-locked averaging. The conventional ERP analysis showed that, compared with the critical words in CON, those in SEM and SEM+SYN elicited an N400-P600 biphasic pattern. The N400 effects in both violation conditions were of similar size and distribution, but the P600 in SEM+SYN was bigger than that in SEM. Compared with the conventional ERP analysis, RIDE analysis revealed a larger N400 effect and an earlier P600 effect (in the time window of 500-800 ms instead of 570-810ms). Overall, the combination of conventional ERP analysis and the RIDE method for compensating for trial-to-trial variability confirmed the non-significant difference between SEM and SEM+SYN in the earlier N400 time window. Converging with previous findings on other Chinese structures, the currentstudy provides further precise evidence that syntactic processing in Chinese does not occur earlier than semantic processing.Link_to_subscribed_fulltex
Parafoveal and foveal N400 effects in natural reading:A timeline of semantic processing from fixation-related potentials
The depth at which parafoveal words are processed during reading is an ongoing topic of debate. Recent studies using RSVP-with-flanker paradigms have shown that implausible words within sentences elicit N400 components while they are still in parafoveal vision, suggesting that the semantics of parafoveal words can be accessed to rapidly update the sentence representation. To study this effect in natural reading, we combined the co-registration of eye movements and EEG with the deconvolution modeling of fixation-related potentials (FRPs) to test whether semantic plausibility is processed parafoveally during Chinese sentence reading. For one target word per sentence, both its parafoveal and foveal plausibility were orthogonally manipulated using the boundary paradigm. Consistent with previous eye movement studies, we observed a delayed effect of parafoveal plausibility on fixation durations that only emerged on the foveal word. Crucially, in FRPs aligned to the pre-target fixation, a clear N400 effect emerged already based on parafoveal plausibility, with more negative voltages for implausible previews. Once participants fixated the target, we again observed an N400 effect of foveal plausibility. Interestingly, this foveal N400 was absent whenever the preview had been implausible, indicating that when a word’s (im)plausibility is already processed in parafoveal vision, this information is not revised anymore upon direct fixation. Implausible words also elicited a late positive complex (LPC), but exclusively in foveal vision. Our results provide convergent neural and behavioral evidence for the parafoveal uptake of semantic information, but also indicate different contributions of parafoveal versus foveal information towards higher-level sentence processing
21 cm foreground removal using AI and frequency-difference technique
The deep learning technique has been employed in removing foreground
contaminants from 21 cm intensity mapping, but its effectiveness is limited by
the large dynamic range of the foreground amplitude. In this study, we develop
a novel foreground removal technique grounded in U-Net networks. The essence of
this technique lies in introducing an innovative data preprocessing step
specifically, utilizing the temperature difference between neighboring
frequency bands as input, which can substantially reduce the dynamic range of
foreground amplitudes by approximately two orders of magnitude. This reduction
proves to be highly advantageous for the U-Net foreground removal. We observe
that the HI signal can be reliably recovered, as indicated by the
cross-correlation power spectra showing unity agreement at the scale of Mpc in the absence of instrumental effects. Moreover, accounting for
the systematic beam effects, our reconstruction displays consistent
auto-correlation and cross-correlation power spectrum ratios at the
level across scales Mpc, with only a 10% reduction
observed in the cross-correlation power spectrum at Mpc. The
effects of redshift-space distortion are also reconstructed successfully, as
evidenced by the quadrupole power spectra matching. In comparison, our method
outperforms the traditional Principal Component Analysis method, which derived
cross-correlation ratios are underestimated by around 75%. We simulated various
white noise levels in the map and found that the mean cross-correlation ratio
when the level of the thermal noise is
smaller than or equal to that of the HI signal. We conclude that the proposed
frequency-difference technique can significantly enhance network performance by
reducing the amplitude range of foregrounds and aiding in the prevention of HI
loss.Comment: 18 pages, 16 figure
Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer\u27s Disease Progression
Alzheimer\u27s disease (AD) displays a long asymptomatic stage before dementia. We characterize AD stage-associated molecular networks by profiling 14,513 proteins and 34,173 phosphosites in the human brain with mass spectrometry, highlighting 173 protein changes in 17 pathways. The altered proteins are validated in two independent cohorts, showing partial RNA dependency. Comparisons of brain tissue and cerebrospinal fluid proteomes reveal biomarker candidates. Combining with 5xFAD mouse analysis, we determine 15 Aβ-correlated proteins (e.g., MDK, NTN1, SMOC1, SLIT2, and HTRA1). 5xFAD shows a proteomic signature similar to symptomatic AD but exhibits activation of autophagy and interferon response and lacks human-specific deleterious events, such as downregulation of neurotrophic factors and synaptic proteins. Multi-omics integration prioritizes AD-related molecules and pathways, including amyloid cascade, inflammation, complement, WNT signaling, TGF-β and BMP signaling, lipid metabolism, iron homeostasis, and membrane transport. Some Aβ-correlated proteins are colocalized with amyloid plaques. Thus, the multilayer omics approach identifies protein networks during AD progression
Is preview benefit from word n + 2 a common effect in reading Chinese? Evidence from eye movements
Although most studies of reading English (and other alphabetic languages) have indicated that readers do not obtain preview benefit from word n + 2, Yang, Wang, Xu, and Rayner (2009) reported evidence that Chinese readers obtain preview benefit from word n + 2. However, this effect may not be common in Chinese because the character prior to the target word in Yang et al.’s experiment was always a very high frequency function word. In the current experiment, we utilized a relatively low frequency word n + 1 to examine whether an n + 2 preview benefit effect would still exist and failed to find any preview benefit from word n + 2. These results are consistent with a recent study which indicated that foveal load modulates the perceptual span during Chinese reading (Yan, Kliegl, Shu, Pan, & Zhou, 2010). Implications of these results for models of eye movement control are discussed
The Role of Gender Information in Pronoun Resolution: Evidence from Chinese
Although previous studies have consistently demonstrated that gender information is used to resolve pronouns, the mechanisms underlying the use of gender information continue to be controversial. The present study used event-related potentials (ERPs) to investigate whether working memory modulates the effect of gender information on pronoun resolution. The critical pronoun agreed or disagreed with its antecedent in gender. Moreover, the distance between a pronoun and its antecedent was varied to assess the influence of working memory. Compared with the congruent pronouns, the incongruent pronouns elicited an N400 effect in the short distance condition and a P600 effect in the long distance condition. The results suggest that the effect of gender information on pronoun comprehension is modulated by working memory
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