Image Data Augmentation for Deep Learning: A Survey

Deep learning has achieved remarkable results in many computer vision tasks. Deep neural networks typically rely on large amounts of training data to avoid overfitting. However, labeled data for real-world applications may be limited. By improving the quantity and diversity of training data, data augmentation has become an inevitable part of deep learning model training with image data. As an effective way to improve the sufficiency and diversity of training data, data augmentation has become a necessary part of successful application of deep learning models on image data. In this paper, we systematically review different image data augmentation methods. We propose a taxonomy of reviewed methods and present the strengths and limitations of these methods. We also conduct extensive experiments with various data augmentation methods on three typical computer vision tasks, including semantic segmentation, image classification and object detection. Finally, we discuss current challenges faced by data augmentation and future research directions to put forward some useful research guidance

Perioperative outcomes of zero ischemia radiofrequency ablation-assisted tumor enucleation for renal cell carcinoma: results of 182 patients

Abstract Background To evaluate the perioperative outcomes of zero ischemia radiofrequency ablation-assisted tumor enucleation. Methods Patients undergoing zero ischemia radiofrequency ablation-assisted tumor enucleation were retrospectively identified from July 2008 to March 2013. The tumor was enucleated after RFA treatment. R.E.N.A.L., PADUA and centrality index (C-index) score systems were used to assess each tumor case. We analyzed the correlation of perioperative outcomes with these scores. Postoperative complications were graded with Clavien-Dindo system. Multivariate logistic regression analyses were used to assess risk of complications. Results Among 182 patients assessed, median tumor size, estimated blood loss, hospital stay and operative time were 3.2 cm (IQR 2.8–3.4), 80 ml (IQR 50–120), 7 days (IQR 6–8) and 100 min (IQR 90–120), respectively. All three scoring systems were strongly correlated with estimated blood loss, hospital stay and operative time. We found 3 (1.6%) intraoperative and 23 (12.6%, 13 [7.1%] Grade 1 and 10 [5.5%] Grade 2 & 3a) postoperative complications. The median follow-up was 55.5 months (IQR 45–70). Additionally, the complexities of R.E.N.A.L., PADUA and C-index scores were significantly correlated with complication grades (P < 0.001; P < 0.001; P < 0.001; respectively). As the representative, R.E.N.A.L. score was an independent predictive factor for postoperative complications and patients with a high complexity had an over 24-fold higher risk compared to those with a low complexity (OR 24.360, 95% CI 4.412–134.493, P < 0.001). Conclusions Zero ischemia radiofrequency ablation-assisted tumor enucleation is considered an effective nephron-sparing treatment. Scoring systems could be useful for predicting perioperative outcomes of radiofrequency ablation-assisted tumor enucleation

Association between New Urbanization and Sustainable Transportation: A Symmetrical Coupling Perspective

New urbanization (NU) and sustainable transportation (ST) are two important issues in urbanization, and their symmetrical coupling is an important factor for measuring the development of the urbanization process. To comprehensively explore the symmetrical coupling level of NU and ST in the urbanization process, this study proposed a coupling coordination degree (CCD) model and calculated the CCD values of China&#8217;s nine metropolises using panel data from 2007 to 2016. The results showed that: (1) From the perspective of each city&#8217;s development, the CCD values for Beijing, Tianjin and Chongqing showed a downward trend, and those for Shanghai, Guangzhou, Chengdu and Wuhan exhibited a rising trend, while the CCD values for Zhengzhou and Xi&#8217;an fell initially and then rose gradually; (2) Based on the regions of the nine cities, the CCD values of the eastern cities and the central cities all demonstrated a growth trend, while those of the western cities were consistently lower than the central and eastern cities; however, the western cities experienced the highest growth rate. (3) Predictive results showed that the CCD levels of new urbanization and sustainable transportation in the eastern, central and western cities are projected to remain unchanged. Finally, it is expected that regionally balanced development will be realized in 2025. From the symmetrical coupling perspective, this study measured and predicted the coupling coordination level of NU and ST of nine metropolises undergoing the urbanization process, which provides a theoretical basis for effective decision-making for comprehensive and sustainable development of China&#8217;s urbanization

Interleukin-6-174G/C Polymorphism Contributes to Periodontitis Susceptibility: An Updated Meta-Analysis of 21 Case-Control Studies

Introduction. Chronic Periodontitis (CP) is suggested to be related to gene variations. Present study aims to quantitatively estimate the association between interleukin-6- (IL-6-) 174G/C polymorphism and CP susceptibility. Materials and Methods. Pubmed, Embase, and Web of Science were searched up to May 2016. The meta-analyses were performed using STATA 12.0. Results. 21 studies were yielded. Significant associations were found under heterozygote comparison and dominant model in studies fulfilling HWE (GC versus GG: OR = 0.690, 95% CI = 0.560–0.849, P=0.000; CC + GC versus GG: OR = 0.690, 95% CI = 0.568–0.838, P<0.001); significant associations were found under heterozygote comparison and dominant model in Caucasian studies fulfilling HWE (GC versus GG: OR = 0.752, 95% CI = 0.577–0.980, P=0.035; CC + GC versus GG: OR = 0.737, 95% CI = 0.576–0.944, P=0.016); significant associations were found under allele comparison, heterozygote comparison, and dominant model in Brazilian population (C versus G: OR = 0.648, 95% CI = 0.497–0.845, P=0.001; GC versus GG: OR = 0.621, 95% CI = 0.441–0.876, P=0.007; CC + GC versus GG: OR = 0.649, 95% CI = 0.470–0.896, P=0.009). Conclusion. IL-6 174 polymorphism is associated with CP susceptibility. In Brazilian and Caucasian population, IL-6 174 GG genotype plays as a risk factor to CP

The Role of SLC7A11 in Cancer: Friend or Foe?

SLC7A11 controls the uptake of extracellular cystine in exchange for glutamate at a ratio of 1:1, and it is overexpressed in a variety of tumours. Accumulating evidence has shown that the expression of SLC7A11 is fine-tuned at multiple levels, and plays diverse functional and pharmacological roles in tumours, such as cellular redox homeostasis, cell growth and death, and cell metabolism. Many reports have suggested that the inhibition of SLC7A11 expression and activity is favourable for tumour therapy; thus, SLC7A11 is regarded as a potential therapeutic target. However, emerging evidence also suggests that on some occasions, the inhibition of SLC7A11 is beneficial to the survival of cancer cells, and confers the development of drug resistance. In this review, we first briefly introduce the biological properties of SLC7A11, including its structure and physiological functions, and further summarise its regulatory network and potential regulators. Then, focusing on its role in cancer, we describe the relationships of SLC7A11 with tumourigenesis, survival, proliferation, metastasis, and therapeutic resistance in more detail. Finally, since SLC7A11 has been linked to cancer through multiple approaches, we propose that its contribution and regulatory mechanism require further elucidation. Thus, more personalised therapeutic strategies should be adapted when targeting SLC7A11

An insecticide target in mechanoreceptor neurons

Hundreds of neurotoxic insecticides are currently in use. However, only a few direct targets have been identified. Here, using Drosophila and the insecticide flonicamid, we identified nicotinamidase (Naam) as a previous unidentified molecular target for an insecticide. Naam is expressed in chordotonal stretch-receptor neurons, and inhibition of Naam by a metabolite of flonicamid, TFNA-AM (4-trifluoromethylnicotinamide), induces accumulation of substrate nicotinamide and greatly inhibits negative geotaxis. Engineered flies harboring a point mutation in the active site show insecticide resistance and defects in gravity sensing. Bees are resistant to flonicamid because of a gene duplication, resulting in the generation of a TFNA-AM-insensitive Naam. Our results, in combination with the absence of genes encoding Naam in vertebrate genomes, suggest that TFNA-AM and potential species-specific Naam inhibitors could be developed as novel insecticides, anthelmintics, and antimicrobials for agriculture and human health

Association of circulating leptin and adiponectin with periodontitis: a systematic review and meta-analysis

Abstract Background This study aimed to assess the difference in serum levels of leptin and adiponectin in patients with periodontitis and in periodontally healthy individuals and evaluate the changes in circulating leptin and adiponectin after periodontal therapy. Leptin and adiponectin are the most generally studied adipokines that function as inflammatory cytokines. Although the association between periodontitis and serum levels of leptin and adiponectin has been studied extensively, the results were not consistent. Methods A systematic search of the Pubmed, Embase, Web of Science, and Cochrane Library up to September 2016 was conducted. The studies were screened and selected by two writers according to the specific eligibility criteria. The quality of included cross-sectional studies was assessed using the quality assessment form recommended by the Agency for Healthcare Research and Quality and Methodological Index for Nonrandomized Studies. The meta-analyses were conducted using the STATA 12.0 software. Results A total of 399 manuscripts were yielded and 25 studies were included in the present meta-analysis. Significantly elevated serum levels of leptin and decreased serum levels of adiponectin in patients with periodontitis were observed in the subgroup analysis of body mass index (BMI) <30. The overall and subgroup analyses showed no significant change in the serum levels of leptin in patients with periodontitis after periodontal treatment. The subgroup analysis of systemically healthy patients showed no significant change in serum levels of adiponectin in patients with periodontitis after periodontal treatment. Conclusions The present meta-analysis supported elevated serum levels of leptin and decreased serum levels of adiponectin in patients with periodontitis compared with controls in the BMI <30 population. In systemically healthy patients with periodontitis, serum levels of leptin and adiponectin do not significantly change after periodontal treatment

Magnesium Isoglycyrrhizinate Reduces the Target-Binding Amount of Cisplatin to Mitochondrial DNA and Renal Injury through SIRT3

Nephrotoxicity is the dose-limiting factor of cisplatin treatment. Magnesium isoglycyrrhizinate (MgIG) has been reported to ameliorate renal ischemia&ndash;reperfusion injury. This study aimed to investigate the protective effect and possible mechanisms of MgIG against cisplatin-induced nephrotoxicity from the perspective of cellular pharmacokinetics. We found that cisplatin predominantly accumulated in mitochondria of renal tubular epithelial cells, and the amount of binding with mitochondrial DNA (mtDNA) was more than twice that with nuclear DNA (nDNA). MgIG significantly lowered the accumulation of cisplatin in mitochondria and, in particular, the degree of target-binding to mtDNA. MgIG notably ameliorated cisplatin-induced changes in mitochondrial membrane potential, morphology, function, and cell viability, while the magnesium donor drugs failed to work. In a mouse model, MgIG significantly alleviated cisplatin-caused renal dysfunction, pathological changes of renal tubules, mitochondrial ultrastructure variations, and disturbed energy metabolism. Both in vitro and in vivo data showed that MgIG recovered the reduction of NAD+-related substances and NAD+-dependent deacetylase sirtuin-3 (SIRT3) level caused by cisplatin. Furthermore, SIRT3 knockdown weakened the protective effect of MgIG on mitochondria, while SIRT3 agonist protected HK-2 cells from cisplatin and specifically reduced platinum-binding activity with mtDNA. In conclusion, MgIG reduces the target-binding amount of platinum to mtDNA and exerts a protective effect on cisplatin-induced renal injury through SIRT3, which may provide a new strategy for the treatment of cisplatin-induced nephrotoxicity

Soil Moisture Regulation under Mulched Drip Irrigation Influences the Soil Salt Distribution and Growth of Cotton in Southern Xinjiang, China

Water deficiency, together with soil salinization, has been seriously restricting sustainable agriculture around the globe for a long time. Optimal soil moisture regulation contributes to the amelioration of soil water and salinity for crops, which is favorable for plant production. A field experiment with five soil water lower limit levels (T1: 85% FC, T2: 75% FC, T3: 65% FC, T4: 55% FC, and T5: 45% FC, where FC is the field capacity) was conducted in southern Xinjiang in 2018 to investigate the responses of soil water–salt dynamics and cotton performance to soil moisture regulation strategies. The results indicated that in the horizontal direction, the farther away the drip irrigation belt, the lower the soil moisture content and the greater the soil salinity. In the vertical direction, the soil moisture and soil salinity increased first and then decreased with an increase in soil depth after irrigation, and the distribution was similar to an ellipse. Moreover, the humid perimeter of soil water and the leaching range of soil salt increased with a decrease in the soil moisture lower limit. Though more soil salt was leached out for the T5 treatment at the flowering stage due to the higher single irrigation amount, soil salinity increased again at the boll setting stage owing to the long irrigation interval. After the cotton was harvested, soil salt accumulated in the 0–100 cm layer and the accumulation amount followed T3 > T5 > T1 > T2 > T4. Moreover, with a decline of soil moisture lower limit, both plant height and nitrogen uptake decreased significantly while the shoot–root ratio increased. Compared with the yield (7233.2 kg·hm−2) and water use efficiency (WUE, 1.27 kg·m−3) of the T1 treatment, the yield for the T2 treatment only decreased by 1.21%, while the WUE increased by 10.24%. Synthetically, considering the cotton yield, water–nitrogen use efficiency, and soil salt accumulation, the soil moisture lower limit of 75% FC is recommended for cotton cultivation in southern Xinjiang, China