64 research outputs found

    Transcriptional regulation of the urokinase receptor (u-PAR) - A central molecule of invasion and metastasis

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    The phenomenon of tumor-associated proteolysis has been acknowledged as a decisive step in the progression of cancer. This short review focuses on the urokinase receptor (u-PAR), a central molecule involved in tumor-associated invasion and metastasis, and summarizes the transcriptional regulation of u-PAR. The urokinase receptor (u-PAR) is a heavily glycosylated cell surface protein and binds the serine protease urokinase specifically and with high affinity. It consists of three similar cysteine-rich repeats and is anchored to the cell membrane via a GPI-anchor. The u-PAR gene comprises 7 exons and is located on chromosome 19q13. Transcriptional activation of the u-PAR promoter region can be induced by binding of transcription factors (Sp1, AP-1, AP-2, NF-kappaB). One current study gives an example for transcriptional downregulation of u-PAR through a PEA3/ets transcriptional silencing element. Knowledge of the molecular regulation of this molecule in tumor cells could be very important for diagnosis and therapy in the near future

    Observation of a new boson at a mass of 125 GeV with the CMS experiment at the LHC

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    The Effect of Sintering Conditions on the Power Loss Characteristics of Mn-Zn Ferrites for High Frequency Applications

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    The sintering temperature significantly changed the microstructure and effected the power loss behavior at the frequency range over 100kHz. The best power loss characteristics at 100kHz-200mT and 500kHz-50mT were observed in the samples sintered at 1300°C and 1250°C, respectively. Those results indicated that the power loss depended on the grain size, electrical resistivity and density of sintered cores. To maintain the stoichiometry at the sintering condition, the ferrite cores were processed on the isocomposition lines within the spinel phase boundary when being cooled. The zinc vapor pressure as well as the oxygen partial pressure was controlled. The high zinc loss condition had an adverse effect on the microstructure of the sintered core surface and degraded the power loss characteristics

    ROBUST TIME OPTIMAL CONTROLLER DESIGN FOR HDD

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