More, More, More: Reducing Thrombosis in Acute Coronary Syndromes Beyond Dual Antiplatelet Therapy-Current Data and Future Directions.

© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.Common to the pathogenesis of acute coronary syndromes (ACS) is the formation of arterial thrombus, which results from platelet activation and triggering of the coagulation cascade.1 To attenuate the risk of future thrombotic events, patients with ACS are treated with dual antiplatelet therapy (DAPT), namely, the combination of aspirin with a P2Y12 inhibitor, such as clopidogrel, ticagrelor, or prasugrel. Despite DAPT, some ≈10% of ACS patients experience recurrent major adverse cardiovascular events over the subsequent 30 days,2 driving the quest for more effective inhibition of thrombotic pathways. In this review, we provide an overview of studies to date and those ongoing that aim to deliver more effective combinations of antithrombotic agents to patients with recent ACS. We have chosen to confine the review to ACS patients without atrial fibrillation because those with atrial fibrillation have a clear indication for combination therapy that includes oral anticoagulation and should, we feel, be treated as a separate cohort. In this article, we discuss the limitations of the currently available clinical trial data and future directions, with suggestions for how practice might change to reduce the risk of coronary thrombosis in those at greatest risk, with minimal impact on bleeding.Peer reviewedFinal Published versio

Spin Dynamics in the LTT Phase of ~1/8 Doped Single Crystal La_{1.67}Eu_{0.2}Sr_{0.13}CuO_4

We present La and Cu NMR relaxation measurements in single crystal La_{1.67}Eu_{0.2}Sr_{0.13}CuO_4. A strong peak in the La spin-lattice relaxation rate observed in the spin ordered state is well-described by the BPP mechanism[1] and arises from continuous slowing of electronic spin fluctuations with decreasing temperature; these spin fluctuations exhibit XY-like anisotropy in the ordered state. The spin pseudogap is enhanced by the static charge-stripe order in the LTT phase.Comment: Four pages, three figure

Estimating Preferences For Water Quality Improvements Using A Citizens' Jury And Choice Modelling: A Case Study On The Bremer River Catchment, South East Queensland

This paper describes a study undertaken on the Bremer River catchment in south east Queensland. The study informed members of the community about water quality issues in the catchment through a citizens' jury and then solicited their opinion about whether more resources should be devoted towards improving water quality and how much they thought the community should pay. A choice modelling survey was conducted prior to and at the conclusion of the citizens' jury. The jury accepted that more resources should be devoted to improving water quality in the catchment, making a number of pertinent recommendations about how and where additional resources should be directed. In addition, the jury indicated that, in terms of willingness to pay, riparian vegetation was an important ecosystem attribute. Although the preliminary and final models derived for the choice modelling exercise indicate that the models were not equivalent, there was no statistical difference in the implicit prices between the two models. Nevertheless, the confidence interval of the implicit prices narrowed following the provision of information in the citizens' jury and there was an improvement in the statistical reliability of the model

Ferromagnetic resonance imaging of Co films using magnetic resonance force microscopy

Lateral one-dimensional imaging of cobalt (Co) films by means of microscopic ferromagnetic resonance (FMR) detected using the magnetic resonance force microscope (MRFM) is demonstrated. A novel approach involving scanning a localized magnetic probe is shown to enable FMR imaging in spite of the broad resonance linewidth. We introduce a spatially selective local field by means of a small, magnetically polarized spherical crystallite of yttrium iron garnet (YIG). Using MRFM-detected FMR signals from a sample consisting of two Co films, we can resolve the ∼20 μm lateral separation between the films. The results can be qualitatively understood by consideration of the calculated spatial profiles of the magnetic field generated by the YIG sphere

Inhomogeneous Low Frequency Spin Dynamics in La_{1.65}Eu_{0.2}Sr_{0.15}CuO_4

We report Cu and La nuclear magnetic resonance (NMR) measurements in the title compound that reveal an inhomogeneous glassy behavior of the spin dynamics. A low temperature peak in the La spin lattice relaxation rate and the ``wipeout'' of Cu intensity both arise from these slow electronic spin fluctuations that reveal a distribution of activation energies. Inhomogeneous slowing of spin fluctuations appears to be a general feature of doped lanthanum cuprate.Comment: 4 pages, 2 figures. Very slight modifications to figure

An Over-Massive Black Hole in a Typical Star-Forming Galaxy, 2 Billion Years After the Big Bang

Supermassive black holes (SMBHs) and their host galaxies are generally thought to coevolve, so that the SMBH achieves up to about 0.2 to 0.5% of the host galaxy mass in the present day. The radiation emitted from the growing SMBH is expected to affect star formation throughout the host galaxy. The relevance of this scenario at early cosmic epochs is not yet established. We present spectroscopic observations of a galaxy at redshift z = 3.328, which hosts an actively accreting, extremely massive BH, in its final stages of growth. The SMBH mass is roughly one-tenth the mass of the entire host galaxy, suggesting that it has grown much more efficiently than the host, contrary to models of synchronized coevolution. The host galaxy is forming stars at an intense rate, despite the presence of a SMBH-driven gas outflow.Comment: Author's version, including the main paper and the Supplementary Materials (16+21 pages, 3+3 figures