Changes in the physical functions of pre-frail elderly women after participation in a 1-year preventative exercise program

Aim: The present study clarifies the effects of participation in a preventative health classroom program (exercise program) for 1 year on the physical functions of pre-frail elderly individuals in comparison with healthy elderly individuals. Methods: Participants in the study included 28 elderly pre-frail female participants and 28 elderly healthy female participants. Participants engaged in the exercise program for 1 year. There was no significant age or physical differences between both groups. Before and after the exercise program, the following physical function tests were carried out: grip strength, one-legged balance with eyes open, 5-m walking time and a timed up & go (TUG). Results: The pre-frail elderly group tested significantly lower in the one-legged balance with eyes open test and the TUG test compared with the healthy elderly group. The 5-m walking time test improved significantly in both groups, but the TUG improved only in the pre-frail elderly group. Conversely, the grip strength and one-legged balance with eyes open tests remained unchanged. Conclusion: Improvements in the TUG and 5-m walking time tests were found in the pre-frail elderly group after the 1-year exercise program. Their results in the TUG test might be greater than those among the healthy elderly individuals. © 2013 Japan Geriatrics Society

microRNA-345の過剰発現は、MUC1およびTJP2の発現を抑制することにより、膵管腺癌細胞株の浸潤能に影響を及ぼす

The majority of pancreatic carcinomas are pancreatic ductal adenocarcinomas (PDAC), and the presence of non-invasive pancreatic intraepithelial neoplasia or intraductal papillary mucinous neoplasm, as an associated lesion, is considered important. These microscopic hyperplastic or grossly papillomatous lesions exhibit varying degrees of morphological atypia and may develop into invasive carcinomas. In this study, we investigated whether mucin-1 (MUC1) is involved in the progression of pancreatic carcinoma and examined the mechanisms by which microRNAs regulate MUC1 expression in vitro. In PDAC cell lines, suppression of MUC1 expression reduced cell proliferation and invasion; PDAC cell lines transfected with an miR-345 precursor suppressed the expression of MUC1, and reduced cell proliferation and invasion. Tight junction protein 2 (TJP2), a putative target of miR-345, is regulated by MUC1. The suppression of TJP2 expression reduced cell proliferation by inducing apoptosis. These results suggest that MUC1 and TJP2, the putative target molecules of miR-345, are critical in maintaining the invasive potential of pancreatic carcinoma cells, and regulating their expression may prevent the progression of non-invasive pancreatic intraductal lesions to invasive carcinomas. This study provides new insights for the development of novel molecular targeted therapies for pancreatic carcinomas.博士（医学）・甲第866号・令和5年3月15

L'année psychologique. 1987 vol. 87, n°4.

13301甲第4330号博士（学術）金沢大学博士論文本文Ful

Maintenance Period

Abstract Effective exercise therapy in rehabilitation during maintenance period is important for the extension of life expectancy in the elderly patients with cardiac diseases. The effects of different participation frequencies in rehabilitation classes on physical functions in this cohort and their sex-related differences have been little examined. This study aimed to examine the effects of different participation frequency in rehabilitation classes on physical function, and sex-related differences. Participants were 167 elderly individuals with cardiac diseases during maintenance period (males, n = 78; mean age, 76.5 years; SD = 6.0 years; females, n = 89; mean age, 75.5 years; SD = 4.5 years) who registered for a 1-year twice a week exercise therapy program. They performed eight physical functioning tests 1 year later. Participants were classified into a low participation group that demonstrated <40% adherence (male, 17; female, 17) and a high participation group that demonstrated ≥70% adherence (male, 29; female, 46) based on participation rates in the exercise therapy program for 1 year. A significant interaction was found for one-legged balance with eyes open; this effect was stronger in the high participation group than in the low participation group in males, and higher in females than in males in the low participation group. Sit-ups and 6-min walking were superior in the high participation group compared with the low participation group. Males were superior in grip strength and sit-up. Females were superior in sitting trunk flexion. In conclusion, elderly patients with high participation frequency in rehabilitation classes were superior in muscle endurance and total endurance compared with those with low participation frequency. Males were superior in muscle strength and muscle endurance; females were superior in flexibility