A randomized clinical trial comparing family-focused treatment and individual supportive therapy for depression in childhood and early adolescence

OBJECTIVE: Despite the morbidity and negative outcomes associated with early-onset depression, few studies have examined the efficacy of psychosocial treatment for depressive disorders during childhood. Integrating family in treatment could have particularly salutary effects during this developmental period. This trial compared immediate posttreatment effects of family-focused treatment for childhood depression (FFT-CD) with those of individual supportive psychotherapy (IP) for children 7 to 14 years old with depressive disorders. METHOD: Children were randomized to 15 sessions of FFT-CD (n = 67) or IP (n = 67) over 4 months. The primary treatment outcome was adequate clinical depression response, defined as at least a 50% decrease in score on the Children's Depression Rating Scale-Revised (CDRS-R). Additional outcomes included patient-centered outcomes (parent- and child-reported treatment satisfaction), remission (defined as CDRS-R score ≤28), change in continuous CDRS-R score, and change in child and parent reports of depressive and non-depressive symptoms and social adjustment. RESULTS: Significant improvement was evident across groups for depressive and non-depressive symptoms, global response, and functioning and social adjustment. Compared with children randomized to IP, children randomized to FFT-CD showed higher rates of adequate clinical depression response (77.7% versus 59.9%; number needed to treat = 5.72; odds ratio 2.29; 95% CI 1.001-5.247; t = 1.97, p = .0498). Across treatments, families reported high satisfaction; compared with IP families, FFT-CD families reported greater knowledge and skills for managing depression. There were no significant differences between treatment arms on secondary outcomes. CONCLUSION: Results support the value of psychosocial intervention, emphasize the important role that families play, and highlight the potential for FFT-CD for supporting recovery in children with depression. Clinical trial registration information-Systems of Support Study for Childhood Depression; http://clinicaltrials.gov; NCT01159041.R01 MH082856 - NIMH NIH HHS; R01 MH082861 - NIMH NIH HH

Measurement of excited-state transitions in cold calcium atoms by direct femtosecond frequency-comb spectroscopy

We apply direct frequency-comb spectroscopy, in combination with precision cw spectroscopy, to measure the ${\rm 4s4p} ^3P_1 \to {\rm 4s5s} ^3S_1$ transition frequency in cold calcium atoms. A 657 nm ultrastable cw laser was used to excite atoms on the narrow ($\gamma \sim 400$ Hz) ${\rm 4s^2} ^1S_0 \to {\rm 4s4p} ^3P_1$ clock transition, and the direct output of the frequency comb was used to excite those atoms from the ${\rm 4s4p} ^3P_1$ state to the ${\rm 4s5s} ^3S_1$ state. The resonance of this second stage was detected by observing a decrease in population of the ground state as a result of atoms being optically pumped to the metastable ${\rm 4s4p} ^3P_{0,2}$ states. The ${\rm 4s4p} ^3P_1 \to {\rm 4s5s} ^3S_1$ transition frequency is measured to be $\nu = 489 544 285 713(56)$ kHz; which is an improvement by almost four orders of magnitude over the previously measured value. In addition, we demonstrate spectroscopy on magnetically trapped atoms in the ${\rm 4s4p} ^3P_2$ state.Comment: 4 pages 5 figure

Is all risk bad? Young adult cigarette smokers fail to take adaptive risk in a laboratory decision-making test

RationaleCigarette smoking has been linked to real-world risky behavior, but this association has been based largely on retrospective self-reports. Limitations of self-report data can be avoided by using laboratory, performance-based measures, such as the Balloon Analogue Risk Task (BART; Lejuez et al., J Exp Psychol Appl 8:75-84, 2002). Initial studies have suggested that smokers display greater risk-taking on this task than nonsmokers, but these studies did not account for drug abuse and psychiatric comorbidities, which are commonplace among smokers.ObjectivesWe sought to examine the performance of smokers and nonsmokers on the BART after excluding drug abuse and psychiatric comorbidities.MethodsWe conducted a study of late adolescent/young adult (age 18 to 21) smokers (n = 26) and nonsmokers (n = 38) performing the BART and excluded individuals with positive drug or alcohol toxicology screens, substance abuse or dependence diagnoses, and/or current psychiatric conditions.ResultsContrary to previous findings, smokers did not display greater risk-taking on the BART than nonsmokers. In fact, when performance was examined trial-by-trial, the nonsmokers displayed progressively greater pumping relative to smokers over time (p < .001), earning them a nonsignificantly greater amount of money than the smokers. Controlling for smoking status, additional analyses revealed that pumping on the BART was positively associated with years of education, nonverbal IQ, and employment.ConclusionsThe results suggest that in young adults, smoking may be associated with a failure to take risks in situations where risk-taking is adaptive

Preliminary heavy-light decay constants from the MILC collaboration

Preliminary results from the MILC collaboration for $f_B$, $f_{B_s}$, $f_D$, $f_{D_s}$ and their ratios are presented. We compute in the quenched approximation at $\beta=6.3$, 6.0 and 5.7 with Wilson light quarks and static and Wilson heavy quarks. We attempt to quantify systematic errors due to finite volume, finite lattice spacing, large $am$, and fitting and extrapolation uncertainties. The hopping parameter approach of Henty and Kenway is used to treat the heavy quarks; the sources are Coulomb gauge gaussians.Comment: 3 pages, compressed postscript (uufiles), talk given at Lattice '9

Non-equilibrium raft-like membrane domains under continuous recycling

We present a model for the kinetics of spontaneous membrane domain (raft) assembly that includes the effect of membrane recycling ubiquitous in living cells. We show that the domains have a broad power-law distribution with an average radius that scales with the 1/4 power of the domain lifetime when the line tension at the domain edges is large. For biologically reasonable recycling and diffusion rates the average domain radius is in the tens of nm range, consistent with observations. This represents one possible link between signaling (involving rafts) and traffic (recycling) in cells. Finally, we present evidence that suggests that the average raft size may be the same for all scale-free recycling schemes.Comment: 8 pages, 5 figure

Scaling studies of QCD with the dynamical HISQ action

We study the lattice spacing dependence, or scaling, of physical quantities using the highly improved staggered quark (HISQ) action introduced by the HPQCD/UKQCD collaboration, comparing our results to similar simulations with the asqtad fermion action. Results are based on calculations with lattice spacings approximately 0.15, 0.12 and 0.09 fm, using four flavors of dynamical HISQ quarks. The strange and charm quark masses are near their physical values, and the light-quark mass is set to 0.2 times the strange-quark mass. We look at the lattice spacing dependence of hadron masses, pseudoscalar meson decay constants, and the topological susceptibility. In addition to the commonly used determination of the lattice spacing through the static quark potential, we examine a determination proposed by the HPQCD collaboration that uses the decay constant of a fictitious "unmixed s bar s" pseudoscalar meson. We find that the lattice artifacts in the HISQ simulations are much smaller than those in the asqtad simulations at the same lattice spacings and quark masses.Comment: 36 pages, 11 figures, revised version to be published. Revisions include discussion of autocorrelations and several clarification

QCD equation of state at non-zero chemical potential

We present our new results for the QCD equation of state at nonzero chemical potential at N_t=6 and compare them with N_t=4. We use the Taylor expansion method with terms up to sixth order in simulations with 2+1 flavors of improved asqtad quarks along a line of constant physics with m_l=0.1 m_s and approximately physical strange quark mass m_s.Comment: 7 pages, 10 figures, presented at Lattice 2008 (Nonzero Temperature and Density), College of William and Mary, Williamsburg, V