Major inclusion and exclusion criteria of studies included in the meta-analysis.

<p>Major inclusion and exclusion criteria of studies included in the meta-analysis.</p

Characteristics of the in-trial population of studies included in the meta-analysis.

<p>All data are mean (SD) unless specified otherwise</p><p>HYPO, Hypothermic arm; STD, Standard care arm; NA, not available; NE, neonatal encephalopathy.</p>*<p>Original number recruited into cooled and standard care arms. Nineteen infants in the cooled arm were then excluded and a further 19 lost to follow up. Two infants in the standard care arm were subsequently excluded and a further 22 lost to follow up. Thus the authors reported outcome data on 100 and 94 standard care infants.</p

Characteristics of excluded studies.

<p>ND, not described; NE, neonatal encephalopathy.</p

Quality of included studies.

<p>Quality of included studies.</p

Funnel plot of the included studies.

<p>Funnel plot of the included studies.</p

Effect of cooling on neonatal sepsis.

<p>Effect of cooling on neonatal sepsis.</p

Effect of cooling on neonatal mortality.

<p>Effect of cooling on neonatal mortality.</p

Early childhood outcomes of infants according to Sarnat neonatal encephalopathy staging.

<p>Values are frequency (% of n);</p><p>*Normal outcome defined as Bayley III cognitive score ≥85 and motor composite score ≥82; with normal head growth; normal neurological examination; normal vision and hearing; and no ongoing seizures at 3½ years.</p

Whole-brain white matter FA according to perinatal clinical assessment.

<p>p value maps are displayed as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087874#pone-0087874-g002" target="_blank">Figure 2</a>. Neuro = neurological; Ther. hypotherm. = therapeutic hypothermia.</p

Whole-brain white matter FA according to outcome assessment aged 3½ years.

<p>p value maps are displayed as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087874#pone-0087874-g002" target="_blank">Figure 2</a>, only using those with 3½ year outcome data for group-wise comparisons. Low Bayley III = infants with scores below predefined cut-offs for Bayley III (<82 for composite motor score, <85 for composite cognitive score); Slow head growth = isolated slow head growth (fall in head circumference centile from birth to follow-up of >2 standard deviations), with otherwise normal neurological examination and Bayley III scores.</p