6 research outputs found
An attempt for an Emergent Scenario with Modified Chaplygin Gas
The present work is an attempt for emergent universe scenario with modified
Chaplygin gas. The universe is chosen as spatially flat FRW space-time with
modified Chaplygin gas as the only cosmic substratum. It is found that emergent
scenario is possible for some specific (unrealistic) choice of the parameters
in the equation of state for modified Chaplygin gas.Comment: 7 pages, 3 figure
How does Inflation Depend Upon the Nature of Fluids Filling Up the Universe in Brane World Scenario
By constructing different parameters which are able to give us the
information about our universe during inflation,(specially at the start and the
end of the inflationary universe) a brief idea of brane world inflation is
given in this work. What will be the size of the universe at the end of
inflation,i.e.,how many times will it grow than today's size is been speculated
and analysed thereafter. Different kinds of fluids are taken to be the matter
inside the brane. It is observed that in the case of highly positive pressure
grower gas like polytropic,the size of the universe at the end of inflation is
comparitively smaller. Whereas for negative pressure creators (like chaplygin
gas) this size is much bigger. Except thse two cases, inflation has been
studied for barotropic fluid and linear redshift parametrization too. For them the size of the universe after
inflation is much more high. We also have seen that this size does not depend
upon the potential energy at the end of the inflation. On the contrary, there
is a high impact of the initial potential energy upon the size of inflation.Comment: 20 page
Microhardness study of the nonlinear optical crystal L-arginine hydrochloride monohydrate
Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19
We evaluated the incidence, distribution, and histopathologic correlates of microvascular brain lesions in patients with severe COVID-19. Sixteen consecutive patients admitted to the intensive care unit with severe COVID-19 undergoing brain MRI for evaluation of coma or neurologic deficits were retrospectively identified. Eleven patients had punctate susceptibility-weighted imaging (SWI) lesions in the subcortical and deep white matter, eight patients had >10 SWI lesions, and four patients had lesions involving the corpus callosum. The distribution of SWI lesions was similar to that seen in patients with hypoxic respiratory failure, sepsis, and disseminated intravascular coagulation. Brain autopsy in one patient revealed that SWI lesions corresponded to widespread microvascular injury, characterized by perivascular and parenchymal petechial hemorrhages and microscopic ischemic lesions. Collectively, these radiologic and histopathologic findings add to growing evidence that patients with severe COVID-19 are at risk for multifocal microvascular hemorrhagic and ischemic lesions in the subcortical and deep white matter.National Institute of Neurological Disorders and Stroke (Grants R21NS109627, R21AG067562, RF1NS115268)NIH Director’s Office (Grant DP2HD101400)NIH National Institute of Mental Health (Grant K23MH115812)NIH National Institutes of Allergy and Infectious Diseases (Grant 2U19AI110818
Electroencephalographic Abnormalities are Common in COVID-19 and are Associated with Outcomes
Objective: The aim was to determine the prevalence and risk factors for electrographic seizures and other electroencephalographic (EEG) patterns in patients with Coronavirus disease 2019 (COVID-19) undergoing clinically indicated continuous electroencephalogram (cEEG) monitoring and to assess whether EEG findings are associated with outcomes. Methods: We identified 197 patients with COVID-19 referred for cEEG at 9 participating centers. Medical records and EEG reports were reviewed retrospectively to determine the incidence of and clinical risk factors for seizures and other epileptiform patterns. Multivariate Cox proportional hazards analysis assessed the relationship between EEG patterns and clinical outcomes. Results: Electrographic seizures were detected in 19 (9.6%) patients, including nonconvulsive status epilepticus (NCSE) in 11 (5.6%). Epileptiform abnormalities (either ictal or interictal) were present in 96 (48.7%). Preceding clinical seizures during hospitalization were associated with both electrographic seizures (36.4% in those with vs 8.1% in those without prior clinical seizures, odds ratio [OR] 6.51, p = 0.01) and NCSE (27.3% vs 4.3%, OR 8.34, p = 0.01). A pre-existing intracranial lesion on neuroimaging was associated with NCSE (14.3% vs 3.7%; OR 4.33, p = 0.02). In multivariate analysis of outcomes, electrographic seizures were an independent predictor of in-hospital mortality (hazard ratio [HR] 4.07 [1.44–11.51], p < 0.01). In competing risks analysis, hospital length of stay increased in the presence of NCSE (30 day proportion discharged with vs without NCSE: HR 0.21 [0.03–0.33] vs 0.43 [0.36–0.49]). Interpretation: This multicenter retrospective cohort study demonstrates that seizures and other epileptiform abnormalities are common in patients with COVID-19 undergoing clinically indicated cEEG and are associated with adverse clinical outcomes. ANN NEUROL 2021;89:872–883.SCOPUS: ar.jinfo:eu-repo/semantics/publishe