Concept of Symmetrical Component as a Technique for analysis of fault and Improvement of Over current Protection Scheme

Electrical energy is one of the fundamental resources of the modern industrial society. Electrical power is available to the user instantly, at the correct voltage and frequency, at exactly the amount needed. The power system maintains its steady state mainly because of the correct and quick remedial action taken by the protective relaying equipment. The response of the protection system must be automatic, quick, and should cause a minimum amount of disruption to the power system. Concept of Symmetrical component for an enhancing protection scheme shows an outstanding feature. The method of symmetrical components provides a practical technology for understanding and analyzing power system operation during unbalanced conditions. Such as those caused by faults between phases and/or ground, open phases, unbalance impedances, and so on. Also, many protective relays operate from the symmetrical component quantities. Thus a good understanding of this subject is of great value and very important tool in protection. In this paper how the concept of symmetrical components helps for improvement of different protection schemes

IMPORTANCE OF HERBAL ANTI-HYPERLIPIDEMICS IN CARDIAC DISORDERS AND HYPERGLYCAEMIA

In recent years, herbal remedies have evolved with enormous impending of alleviate.  Herbal medicine progress against the non-communicable disease like diabetes is one of the propel area of research in the field of worldwide medicine. Hyperlipidemia is a disorder of lipid metabolism manifested by increase of plasma concentrations of the assortment of lipid and lipoprotein fractions. Hyperlipidemia has been one of the maximum risk factors contributing to the occurrence and relentlessness of coronary heart diseases. HMG Co A reductase is a key enzyme involving in rate limiting step of cholesterol biosynthesis. Conservative anti-hyperlipidemic drugs have restricted efficacies and vital side effects, so that alternative lipid lowering agents are required. This review explains the plants possessing significant anti-hyperlipidemic activity with their botanical name, family, part used, extract used and inducing agent of hyperlipidemia Keywords: Herbal sources, Coronary heart diseases, Anti-hyperlipidemic activity, HMG Co A reductas

Synthesis and Evaluation of c-Src Kinase Inhibitory Activity of Pyridin-2(1H)-one Derivatives

Src kinase, a prototype member of the Src family of kinases (SFKs), is over-expressed in various human tumors, and has become a target for anticancer drug design. In this perspective, a series of eighteen 2-pyridone derivatives were synthesized and evaluated for their c-Src kinase inhibitory activity. Among them, eight compounds exhibited c-Src kinase inhibitory activity with IC50 value of less than 25 μM. Compound 1-[2-(dimethylamino)ethyl]-5-(2-hydroxy-4-methoxybenzoyl)pyridin-2(1H)-one (36) exhibited the highest c-Src kinase inhibition with an IC50 value of 12.5 μM. Further the kinase inhibitory potential of compound 36 was studied for EGFR, MAPK and PDK, however no significant activity was observed at the highest tested concentration (300 μM). These results provide insights for further optimization of this scaffold for designing the next generation of 2-pyridone derivatives as candidate Src kinase inhibitors

Clinico-laboratory profile of dengue patients in a tertiary hospital of Eastern India

Background: Dengue is the most rapidly spreading mosquito-borne viral disease of mankind. According to WHO, about 50-100 million new dengue infections are estimated to occur annually in more than 100 endemic countries.So, the present study has been done to analyzed varied clinical and laboratory profile of confirm dengue cases.Methods: Cross-sectional observational study was undertaken among 106 adult Ig M Ab positive cases admitted during October 2015 to September 2017. All patients were evaluated clinically and subjected for relevant laboratory investigations.Results: In our study male and female ratio was 20.2:1. Most common symptom was fever (95.3%) and least common was jaundice. Second most symptom was headache (70.8%). Myalgia was present in 49.1% of cases. 54.7% had nausea/vomiting. Hypotension was noticed in 33% of cases whereas encephalopathy and melaena was found in 6.6% and 2.83% respectively. Leucopenia was present in 57.5% and thrombocytopenia in 50.9% of cases.Conclusions: Younger male were commonly affected with dengue fever and promptly responded to conservative therapy due to early confirmation of diagnosis. Mortality was only 1.8% cases, may be due to delay in seeking medical attention

Formulation Development Of Nanoparticulate Formulation In Ophthalmic Drug Delivery System

The major challenge faced by today’s pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration, especially for the treatment of anterior segment diseases. Delivery of drugs to the targeted ocular tissues is restricted by various precorneal, dynamic and static ocular barriers. Also, therapeutic drug levels are not maintained for longer duration in target tissues. So, the present work on ocular drug delivery research make advanced towards developing a novel, safe and patient compliant formulation and drug delivery devices/techniques, which may surpass these barriers and maintain drug levels in tissues. Anterior segment drug delivery advances are witnessed by modulation of conventional topical solutions with permeation and viscosity enhancers. Also, it includes development of nano formulations have also been introduced for anterior segment ocular drug delivery. these novel devices and/or formulations are easy to formulate, no/negligibly irritating, possess high precorneal residence time, sustain the drug release, and enhance ocular bioavailability of therapeutics. An update of current research advancement in ocular drug delivery necessitates and helps drug delivery scientists to modulate their process and develop novel and safe drug delivery strategies followed by current nanotechnology-based formulation developments and also, recent developments with other ocular drug delivery strategies employing in situ formulation. &nbsp

Identifying climate risks and assessing differential vulnerability of communities in Ahmednagar and Aurangabad districts of Maharashtra

This series is based on work funded by Canada’s International Development Research Centre (IDRC) and the UK’s Department for International Development (DFID) through the Collaborative Adaptation Research Initiative in Africa and Asia (CARIAA).This study provides an example of how agricultural practices in rural Maharashtra are being transformed in response to changing climate and additional stresses brought on by non-climatic factors. It attempts to understand vulnerability in the context of social differentiation including gender, in selected villages in two districts in Maharashtra state. Through community engagement and use of the Community Driven Vulnerability Evaluation-Program designer tool (CoDriVE-PD) a fast and detailed assessment of climate risks and vulnerabilities can be made. Better understanding is needed to help design policies for adaptation and mitigation, while also designing projects that build adaptive capacities. Many of India’s drought-prone districts are in Maharashtra

Biotransformation of artemisinin mediated through fungal strains for obtaining derivatives with novel activities

Artemisinin, a sesquiterpene lactone, is the active antimalarial constituent of Artemisia annua. Several fungal strains Saccharomyces cerevisiae, Aspergillus flavus, Aspergillus niger and Picchia pastoris were used to biotransform artemisinin. Among these strains, A. flavus was the only microorganism capable of transforming artemisinin to deoxyartemisinin in higher yields than the previous reports. The structure of deoxyartemisinin was elucidated by spectroscopy. Deoxyartemisinin showed antibacterial activity against Staphylococcus aureus, S. epidermidis and S. mutans at a minimum inhibitory concentration (MIC) of 1 mg/mL compared to artemisinin whose MIC was >2 mg/mL

Analysis of Causes of Discarding Blood and its Components in a Blood Bank:A Cross-sectional study

Abstract: In a developing country such as India, each unit of blood/blood component should be considered indispensable and be used judiciously to avert misuse and wastage.Hence, proper utilisation of blood is crucial. This study aims to identify the lacunae in procedures and protocols in blood banksand ascertain measures to minimize wastage of precious blood and blood components.A cross-sectional study was conducted in a regional blood bank in Western Maharashtra over a time duration of 4 years.Highest discard was seen in Random donor platelet unit (46.5%), followed by whole blood units (23.1%) and packed cell volume (3.1%). Expiry was the main reason or discard in PCV (59.9%), RDP (97.2%), and SDP (100%). TTIs were the most common cause of discarding blood unit in FFP (77.3%) and WB (82.6%).The findings of this study emphasize on the need for strict adherence to Standard Operating Protocols (SOP) and donor selection criteria, meticulous history taking, thorough counselling and exhaustive record keepin