Comparison of the effect of no drug (0) compared with maximum (M) dose for LABE (4000 mg/ml), HDZ (1000 mg/ml), Mdopa (10,000 mg/ml) and Pravastatin (20 mg/ml) after 1 day in culture at ambient O₂ on the median (SD) levels of placental hormones (Fig. 1A) and angiogenic protein (Fig. 1B).

<p>The beta errors for no drug versus max dose of Mdopa are: 0.0465 & 02451 on Inhibin A; 0.0001 & 0.9761 on Activin A; 0.0019 & 0.0367 for hCG; 0.0655 & 0.0054 for sFlt-1 and 0.0559 & 0.1977 for sEng, respectively.</p

Demographic details of the participants in the study given as median and interquartile range (25^th, 75^th percentiles).

<p>Demographic details of the participants in the study given as median and interquartile range (25^th, 75^th percentiles).</p

Scatter plot of circulating levels of serum soluble Endoglin (sEndog) in the different groups of women with median and interquartile range.

<p>Group 1 (non-pregnant women, n = 14), group 2 (normal pregnant women, women, n = 32), group 3 (threatened miscarriage patients with a live birth outcome, n = 21) and group 4 (threatened miscarriage patients with a subsequent miscarriage, n = 19). General linear analysis of variance was carried out to study the statistical significance between the groups with posthoc tests. P<0.001 = ***.</p

Scatter plot of circulating levels of serum heat shock protein 70 (Hsp 70) in the different groups of women with median and interquartile range.

<p>Group 1 (non-pregnant women, n = 14), group 2 (normal pregnant women, n = 32), group 3 (threatened miscarriage patients with a live birth outcome, n = 21) and group 4 (threatened miscarriage patients with a subsequent miscarriage, n = 19). General linear analysis of variance was carried out to study the statistical significance between the groups with posthoc tests. NS = not significant.</p

Scatter plot of circulating levels of serum placental growth factor (PlGF) in the different groups of women with median and interquartile range.

<p>Group 1 (non-pregnant women, n = 14), group 2 (normal pregnant women, n = 32), group 3 (threatened miscarriage patients with a live birth outcome, n = 21) and group 4 (threatened miscarriage patients with a subsequent miscarriage, n = 19). General linear analysis of variance was carried out to study the statistical significance between the groups with posthoc tests. P<0.001 = ***, P<0.01 = **.</p

Scatter plot of circulating levels of serum soluble VEGF receptor 1 (sFLT-1) in the different groups of women with median and interquartile range.

<p>Group 1 (non-pregnant women, n = 14), group 2 (normal pregnant women, n = 32), group 3 (threatened miscarriage patients with a live birth outcome, n = 21) and group 4 (threatened miscarriage patients with a subsequent miscarriage, n = 19). General linear analysis of variance was carried out to study the statistical significance between the groups with posthoc tests. P<0.001 = ***.</p