Concurrent reactive arthritis and myelitis – a case report

Reactive arthritis is a post infectious multisystem illness which usually occurs after episodes of diarrhoea or urinary tract infections. It can cause many manifestations other than the musculoskeletal system including skin, urogenital system and eyes. However the central nervous system is only occasionally involved. We discuss the case of a 32 year old male who presented with myelitis in association with reactive arthritis

Acute hepatic failure due to dengue: A case report

Dengue is an arboviral disease endemic in many parts of the world. Although it is known to cause hepatic involvement commonly, it only occasionally results in acute hepatic failure. We present the case of a young male who developed acute hepatic failure due to dengue. The differentials and the management is discussed

Vaccination Status and Outcome of Patients at a Dedicated COVID-19 Centre, Delhi, India: A Retrospective Study

Introduction: Coronavirus Disease-2019 (COVID-19) vaccine provides strong protection against transmission, serious illness, hospitalisation, and death. As India carried out robust vaccination drive covering more than two third of its population, the study was aimed to highlight the effects of vaccination status of patient on the outcome of COVID-19 infection. Aim: To describe the relation of vaccination with disease severity and its outcome during the third wave of COVID-19. Materials and Methods: It was a single-centre retrospective, cross-sectional study conducted in a dedicated COVID-19 Hospital (Guru Tegh Bahadur Hospital) in Delhi, India. A total of 257 patients were admitted between 10th January 2022 to 9th February 2022, and 246 were included in the study. For each individual, demographic, and clinical data was collected. Vaccination data was extracted via the CoWin platform which included vaccine type, as well as date of administration. The profile of patients was established based on clinical examination, laboratory data, nursing record and radiological record during the course of hospitalisation. The clinical outcome was described as discharge, length of hospital stays, and in-hospital death in relation to the vaccination status. Statistical analysis was done using Statistical Package for the Social Sciences (SPSS), version 22.0. Results: Total of 246 patients were divided into three groups- 97 were fully vaccinated, 46 were partially vaccinated and 103 were unvaccinated. Both vaccinated and unvaccinated groups had similar percentage of co-morbidities i.e. 61.3% vs 63.5%. Those who were fully vaccinated were more likely to maintain saturation at room air 30.9% vs 26.1% vs 3.9%, had lesser requirements of mechanical ventilation (6.2% vs 15.2% vs 21.4%), shorter duration of hospital stay (4.2 vs 5.3 vs 7.2 days), and lesser mortality (9.3% vs 21.7% vs 33%) as compared to the partially vaccinated and unvaccinated patients respectively. Conclusion: The beneficial effect of the vaccination was observed in severity, mortality, morbidity, and lesser number of hospitalisations. Hence, vaccination coverage was critical in reducing the severity in reducing the and the hospitalisation in third wave of COVID-19

Baixa mortalidade durante surto de dengue em Nova Délhi, na Índia, em 2008: um estudo clínico-bioquímico

Dengue has become a yearly phenomenon in Delhi. Each outbreak is distinct by way of clinical features, morbidity andmortality. The aim of this study is to analyse the clinical and biochemical profile of dengue in the 2008 outbreak at a tertiarycare institution in India. We analysed the medical records of all cases diagnosed as dengue fever during the period of July2008 to December 2008 in a tertiary care hospital. The study consisted of 103 patients - 63% patients were males. The meanage was 22 years. One third of patients had some cutaneous manifestation. 30 patients had hepatomegaly and 8 hadsplenomegaly. Of uncommon features 2 patients had seizures, 1 had polyserositis and one had acute hepatic failure. RaisedSGPT (>60 U/L) was seen in 60% cases. 23 patients had a platelet count of less than 20,000/mm3. There were no deaths. Thepresent outbreak primarily involved the economically productive age group. The current outbreak was characterised byhigh rate of hepatic involvement.A dengue tem se tornado um fenômeno anual em Nova Deli. Cada surto é distinto do outro por meio de características clínicas,morbidade e mortalidade. O objetivo deste estudo é analisar o perfil clínico e laboratorial da dengue na epidemia de 2008 emuma instituição de atendimento terciário na Índia. Foram analisados os prontuários de todos os casos diagnosticados comodengue durante o período de julho de 2008 a dezembro de 2008 em um hospital terciário. O estudo consistiu de 103 pacientes:63% do sexo masculino; idade média de 22 anos. Um terço dos pacientes apresentavam alguma manifestação cutânea, 30pacientes tinham hepatomegalia e 8 tinham esplenomegalia. De características incomuns, 2 pacientes tiveram convulsões, 1tinha poliserosite e 1 tinha insuficiência hepática aguda. Um aumento da SGPT (>60 U/L) foi observado em 60% dos casos. Vintee três pacientes tiveram uma contagem de plaquetas inferior a 20.000/mm3. Não houve mortes. Este surto envolveu indivíduosde faixa etária economicamente produtiva. O surto também foi caracterizado pelo alto índice de comprometimento hepático

Rectangular ZnO porous nano-plate assembly with excellent acetone sensing performance and catalytic activity

The controlled synthesis of a hierarchically assembled porous rectangular ZnO plate (2.5-3.5 mm length, 1.5-2.5 mm width and 100-150 nm thickness) from bulk ZnO without using any organic substrates, such as solvents/surfactants/structure-directing agents, is presented. The synthesized ZnO plates are single crystalline with exposed (10 (1) over bar0) facets on the flat surface, porous and formed through the calcination of a hydrozincite Zn-5(CO3)(2)(OH)(6)] intermediate. A gas sensor based on the synthesized porous ZnO architecture exhibited high sensitivity towards acetone even in low concentration (S = 3.4 in 1 ppm acetone) with good selectivity. The ZnO nanostructured material as a heterogeneous catalyst also showed excellent catalytic activity for the synthesis of 5-substituted-1H-tetrazoles (yield = 94%). Both the activities are superior than those of other reported ZnO based acetone sensors and heterogeneous catalysts. We believe that the improved properties of the synthesized ZnO nanostructure is due to the exposed (10 (1) over bar0) facets, and its porous and assembled structure, which provides a reasonably large accessible surface area, and facilitates diffusion and mass transport of gas or substrate molecules

Life threatening posterior reversible encephalopathy syndrome in systemic lupus erythematosus

Posterior reversible encephalopathy syndrome (PRES) is a condition characterized by headache, altered mental status, seizure and visual dysfunction, and transient motor deficit. The incidence of PRES in systemic lupus erythematosus (SLE) has not been clearly known. Risk factors for PRES in SLE include hypertension, renal failure, cytotoxic drugs, and active lupus. We describe a patient of SLE with nephritis on cyclophosphamide monthly pulse that developed PRES and, unfortunately, succumbed to her illness