2 research outputs found
Effects of apelin on reproductive functions: relationship with feeding behavior and energy metabolism
Apelin is an adipose tissue derived peptidergic hormone. In this study,
40 male Sprague-Dawley rats were used (four groups; n=10). Apelin-13 at
three different dosages (1, 5 and 50g/kg) was given intraperitoneally
while the control group received vehicle the same route for a period of
14 days. In results, apelin-13 caused significant decreases in serum
testosterone, luteinizing hormone and follicle-stimulating hormone
levels (p<0.05). Administration of apelin-13 significantly increased
body weights, food intake, serum low-density lipoprotein and total
cholesterol levels (p<0.05), but caused significant decreases in
high-density lipoprotein levels (p<0.05). Serum glucose and triglyceride
levels were not significantly altered by apelin-13 administration.
Significant decreases in both uncoupling protein (UCP)-1 levels in the
white and brown adipose tissues and UCP-3 levels in the biceps muscle
(p<0.05) were noted. The findings of the study suggest that apelin-13
may not only lead to obesity by increasing body weight but also cause
infertility by suppressing reproductive hormones