An Extension of Objectification Theory: Examining the Roles of Racial and Cultural Factors on Self-Objectification and Depression Among Asian American Women

Objectification theory proposed the idea that U.S. culture positions women to be viewed as physical entities foremost, typically to the fulfillment of men's sexual desires. The most damaging aspect of this experience is women's internalization of this perspective into their own sense of self, which has been shown to predict body image issues, eating disturbances, depression, sexual dysfunction, reduced psychological flow, and substance abuse. More recently, there have been efforts to examine how multiple layers of oppression may impact the experiences of sexual objectification and its psychological consequences. This study tested an extension of objectification theory on a sample of 618 Asian American women with the inclusion of race-related experiences, Asian American cultural values, and their relationships with the self-objectification process and depression. Findings indicate that the more participants endorsed Asian American cultural values, the more they engaged in a self-objectification process that involved internalizing mainstream ideals of beauty, monitoring their body appearance, and feeling shame and less satisfaction with race-related features and their bodies in general, which then predicted depression. In considering participants' adherence to Asian cultural values, the internalization of mainstream body ideals was necessary to engaging in self-objectification. Similarly, the more participants endorsed experiencing racial and sexual objectification, the more they engaged in the self-objectification process, which predicted depression. However, internalization of mainstream body ideals was not a necessary link between experiencing objectifying events and engaging in other components of the self-objectification process. Furthermore, adherence to Asian American cultural values did not have a significant moderation effect on the self-objectification process as predicted

Reversible Data Hiding in JPEG Images Using Quantized DC

Reversible data hiding in JPEG images has become an important topic due to the prevalence and overwhelming support of the JPEG image format these days. Much of the existing work focuses on embedding using AC (quantized alternating current coefficients) to maximize the embedding capacity while minimizing the distortion and the file size increase. Traditionally, DC (quantized direct current coefficients) are not used for embedding, due to the assumption that the embedding in DCs cause more distortion than embedding in ACs. However, for data analytic which extracts fine details as a feature, distortion in ACs is not acceptable, because they represent the fine details of the image. In this paper, we propose a novel reversible data hiding method which efficiently embeds in the DC. The propose method uses a novel DC prediction method to decrease the entropy of the prediction error histogram. The embedded image has higher PSNR, embedding capacity, and smaller file size increase. Furthermore, proposed method preserves all the fine details of the image

A Social Cost-Benefit Analysis of the Vehicle Restriction Policy for Reducing Overtourism in Udo, Korea

Overtourism has given rise to conflict among various stakeholders. Accordingly, to control overtourism, the public sector has started to implement policies. Recently, Udo off Jeju Island in South Korea has begun experiencing overtourism; to prevent the situation from deteriorating, the public sector implemented a vehicle restriction policy. This study used a cost-benefit analysis framework to assess the social costs and benefits of the public policy to control overtourism in Udo. Through interviews and relevant data and documents, this study classified analysis items related to the policy that could be either a cost or benefit to different stakeholders. The social cost-benefit analysis showed that the net benefit increases, the longer the policy continues, thus ensuring it is adequate and feasible to implement the policy. An effective management public policy for the sustainability of the region’s tourism should always be promoted

Spousal Concordance of Physical Frailty in Older Korean Couples

Marital status is an important risk factor for physical frailty. However, there are limited data on spousal concordance of physical frailty among married couples. Here, we evaluate the spousal concordance of frailty as defined by the Fried frailty phenotype and specific phenotype components that contribute to this association. Data on 315 married couples (630 individuals) aged between 70 and 84 years were obtained from the Korean Frailty and Aging Cohort Study (KFACS). Multivariate logistic regressions were used for the analysis. After adjusting for covariates (age, body mass index, education, house ownership, comorbidity, cognition, depressive symptoms, cohabitation with adult children for both partners), a husband’s frailty was positively associated with his wife’s frailty (odds ratio (OR) 3.34, 95% confidence interval (CI) 1.04–10.73, p < 0.05), and a wife’s frailty was significantly associated with her husband’s frailty (OR 4.62, 95% CI 1.31–16.33, p < 0.05), indicating a greater effect of the frailty status of the spouse among women than among men. Among the five components of the Fried frailty phenotype, weight loss, slowness, and exhaustion were the main contributing factors to the spousal association for frailty. In conclusion, having a frail spouse is a strong and independent risk factor for frailty among community-living older adults

Photo-induced crosslinked and anti-PD-L1 peptide incorporated liposomes to promote PD-L1 multivalent binding for effective immune checkpoint blockade therapy

Immune checkpoint blockade (ICB) therapy targeting PD-L1 via monoclonal antibody (mAb) has shown extensive clinical benefits in the diverse types of advanced malignancies. However, most patients are completely refractory to ICB therapy owing to the PD-L1 recycling mechanism. Herein, we propose photo-induced crosslinked and anti-PD-L1 peptide incorporated liposomes (immune checkpoint blockade liposomes; ICB-LPs) to promote PD-L1 multivalent binding for inducing lysosomal degradation of PD-L1 in tumor cells. The ICB-LPs are prepared by formulation of DC8,9PC with photo-polymerized diacetylenic moiety, 1,2-dipalmitoylphosphatidylcholine (DPPC) and anti-PD-L1 peptide (D-form NYSKPTDRQYHF)-conjugated DSPE-PEG2k (anti-PD-L1-DSPE-PEG2k) in a molar ratio of 45:45:10, followed by cross-linking of liposomal bilayer upon UV irradiation. The 10 mol% anti-PD-L1-DSPE-PEG2k incorporated ICB-LPs have a nano-sized lipid bilayer structure with an average diameter of 137.7 ± 1.04 nm, showing a high stability in serum condition. Importantly, the ICB-LPs efficiently promote the multivalent binding with PD-L1 on the tumor cell membrane, which are endocytosed with aim to deliver PD-L1 to the lysosomes, wherein the durable PD-L1 degradation is observed for 72 h, in contrast to anti PD-L1 mAbs showing the rapid PD-L1 recycling within 9 h. The in vitro co-culture experiments with CD8+ T cells show that ICB-LPs effectively enhance the T cell-mediated antitumor immune responses against tumor cells by blocking the PD-L1/PD-1 axis. When ICB-LPs are intravenously injected into colon tumor-bearing mice, they efficiently accumulate within the targeted tumor tissues via both passive and active tumor targeting, inducing a potent T cell-mediated antitumor immune response by effective and durable PD-L1 degradation. Collectively, this study demonstrates the superior antitumor efficacy of crosslinked and anti-PD-L1 peptide incorporated liposome formulation that promotes PD-L1 multivalent binding for trafficking of PD-L1 toward the lysosomes instead of the recycling endosomes

Cathepsin B-Overexpressed Tumor Cell Activatable Albumin-Binding Doxorubicin Prodrug for Cancer-Targeted Therapy

Prodrugs are bioreversible medications that should undergo an enzymatic or chemical transformation in the tumor microenvironment to release active drugs, which improve cancer selectivity to reduce toxicities of anticancer drugs. However, such approaches have been challenged by poor therapeutic efficacy attributed to a short half-life and low tumor targeting. Herein, we propose cathepsin B-overexpressed tumor cell activatable albumin-binding doxorubicin prodrug, Al-ProD, that consists of a albumin-binding maleimide group, cathepsin B-cleavable peptide (FRRG), and doxorubicin. The Al-ProD binds to in situ albumin, and albumin-bound Al-ProD indicates high tumor accumulation with prolonged half-life, and selctively releases doxorubicin in cathepsin B-overexpressed tumor cells, inducing a potent antitumor efficacy. Concurrently, toxicity of Al-ProD toward normal tissues with innately low cathepsin B expression is significantly reduced by maintaining an inactive state, thereby increasing the safety of chemotherapy. This study offers a promising approach for effective and safe chemotherapy, which may open new avenues for drug design and translational medicine