Long-term Blood Pressure Prediction with Deep Recurrent Neural Networks

Existing methods for arterial blood pressure (BP) estimation directly map the input physiological signals to output BP values without explicitly modeling the underlying temporal dependencies in BP dynamics. As a result, these models suffer from accuracy decay over a long time and thus require frequent calibration. In this work, we address this issue by formulating BP estimation as a sequence prediction problem in which both the input and target are temporal sequences. We propose a novel deep recurrent neural network (RNN) consisting of multilayered Long Short-Term Memory (LSTM) networks, which are incorporated with (1) a bidirectional structure to access larger-scale context information of input sequence, and (2) residual connections to allow gradients in deep RNN to propagate more effectively. The proposed deep RNN model was tested on a static BP dataset, and it achieved root mean square error (RMSE) of 3.90 and 2.66 mmHg for systolic BP (SBP) and diastolic BP (DBP) prediction respectively, surpassing the accuracy of traditional BP prediction models. On a multi-day BP dataset, the deep RNN achieved RMSE of 3.84, 5.25, 5.80 and 5.81 mmHg for the 1st day, 2nd day, 4th day and 6th month after the 1st day SBP prediction, and 1.80, 4.78, 5.0, 5.21 mmHg for corresponding DBP prediction, respectively, which outperforms all previous models with notable improvement. The experimental results suggest that modeling the temporal dependencies in BP dynamics significantly improves the long-term BP prediction accuracy.Comment: To appear in IEEE BHI 201

StoryDroid: Automated Generation of Storyboard for Android Apps

Mobile apps are now ubiquitous. Before developing a new app, the development team usually endeavors painstaking efforts to review many existing apps with similar purposes. The review process is crucial in the sense that it reduces market risks and provides inspiration for app development. However, manual exploration of hundreds of existing apps by different roles (e.g., product manager, UI/UX designer, developer) in a development team can be ineffective. For example, it is difficult to completely explore all the functionalities of the app in a short period of time. Inspired by the conception of storyboard in movie production, we propose a system, StoryDroid, to automatically generate the storyboard for Android apps, and assist different roles to review apps efficiently. Specifically, StoryDroid extracts the activity transition graph and leverages static analysis techniques to render UI pages to visualize the storyboard with the rendered pages. The mapping relations between UI pages and the corresponding implementation code (e.g., layout code, activity code, and method hierarchy) are also provided to users. Our comprehensive experiments unveil that StoryDroid is effective and indeed useful to assist app development. The outputs of StoryDroid enable several potential applications, such as the recommendation of UI design and layout code

A Study of Fermi-LAT GeV gamma-ray Emission towards the Magnetar-harboring Supernova Remnant Kesteven 73 and Its Molecular Environment

We report our independent GeV gamma-ray study of the young shell-type supernova remnant (SNR) Kes 73 which harbors a central magnetar, and CO-line millimeter observations toward the SNR. Using 7.6 years of Fermi-LAT observation data, we detected an extended gamma-ray source ("source A") with the centroid on the west of the SNR, with a significance of 21.6 sigma in 0.1-300 GeV and an error circle of 5.4 arcminute in angular radius. The gamma-ray spectrum cannot be reproduced by a pure leptonic emission or a pure emission from the magnetar, and thus a hadronic emission component is needed. The CO-line observations reveal a molecular cloud (MC) at V_LSR~90 km/s, which demonstrates morphological correspondence with the western boundary of the SNR brightened in multiwavelength. The 12CO (J=2-1)/12CO (J=1-0) ratio in the left (blue) wing 85-88 km/s is prominently elevated to ~1.1 along the northwestern boundary, providing kinematic evidence of the SNR-MC interaction. This SNR-MC association yields a kinematic distance 9 kpc to Kes 73. The MC is shown to be capable of accounting for the hadronic gamma-ray emission component. The gamma-ray spectrum can be interpreted with a pure hadronic emission or a magnetar+hadronic hybrid emission. In the case of pure hadronic emission, the spectral index of the protons is 2.4, very similar to that of the radio-emitting electrons, essentially consistent with the diffusive shock acceleration theory. In the case of magnetar+hadronic hybrid emission, a magnetic field decay rate >= 10^36 erg/s is needed to power the magnetar's curvature radiation.Comment: 7 figures, published in Ap

Dynamic response of water saturated subgrade surface layer under high speed train using moving element method

Since the moving element method (MEM) is an elegant method for solving problems involving moving loads. This paper extends the moving element method to the dynamic response of the water-saturated subgrade surface layer under a high-speed train. The track model is described as the Euler beam to simulate the rail, concrete slab layer and elastic medium to simulate the concrete base layer. The water-saturated subgrade surface layer is characterized by Biot’s dynamic poroelastic theory, and the other subgrade components are regarded as elastic medium. The governing equations are formulated in a coordinate system traveling at a constant velocity, and the associated finite element formulation in a moving frame of reference is derived. The proposed computational scheme is applied to investigate the dynamic characteristics of the water-saturated subgrade surface layer subjected to the moving train load. The effects of various key parameters including the train velocity, permeability, drainage boundary, elastic modulus and rail irregularity on hydro-mechanical response of the saturated subgrade surface layer are carefully analyzed

Automated single-cell motility analysis on a chip using lensfree microscopy.

Quantitative cell motility studies are necessary for understanding biophysical processes, developing models for cell locomotion and for drug discovery. Such studies are typically performed by controlling environmental conditions around a lens-based microscope, requiring costly instruments while still remaining limited in field-of-view. Here we present a compact cell monitoring platform utilizing a wide-field (24 mm(2)) lensless holographic microscope that enables automated single-cell tracking of large populations that is compatible with a standard laboratory incubator. We used this platform to track NIH 3T3 cells on polyacrylamide gels over 20 hrs. We report that, over an order of magnitude of stiffness values, collagen IV surfaces lead to enhanced motility compared to fibronectin, in agreement with biological uses of these structural proteins. The increased throughput associated with lensfree on-chip imaging enables higher statistical significance in observed cell behavior and may facilitate rapid screening of drugs and genes that affect cell motility