Kaplan-Meier curves for subgroups of patients who received oxaliplatin-based adjuvant chemotherapy or surgery alone.

<p>A and B: stage III patients under 50 years of age. C: patients with stage N2 disease. D: patients with stage N2b disease. E and F: patients with mucinous adenocarcinoma.</p

Baseline demographic and cancer characteristics of the 236 patients who underwent radical surgery.

<p>* Statistically significant difference between patient groups (<i>P</i>≤0.05).</p><p>AR, anterior resection; APR, abdominoperineal resection; Group S received surgery alone; Group SO received surgery and oxaliplatin-containing adjuvant chemotherapy.</p><p>Baseline demographic and cancer characteristics of the 236 patients who underwent radical surgery.</p

Five-year survival of the patients after rectal cancer resection.

<p>* Statistically significant difference between patient groups (<i>P</i>≤0.05).</p><p>DSS, disease-specific survival; Group S received surgery alone; Group SO received surgery and oxaliplatin-containing adjuvant chemotherapy; NA, not available; OS, overall survival.</p><p>Five-year survival of the patients after rectal cancer resection.</p

Five-year local recurrence-free survival of the patients after rectal cancer resection.

<p>Group S received surgery alone; Group SO received surgery and oxaliplatin-containing adjuvant chemotherapy; NA, not available; RFS, local recurrence-free survival.</p><p>Five-year local recurrence-free survival of the patients after rectal cancer resection.</p

Concise Synthesis and Biological Evaluation of 2‑Aroyl-5-Amino Benzo[<i>b</i>]thiophene Derivatives As a Novel Class of Potent Antimitotic Agents

The biological importance of microtubules make them an interesting target for the synthesis of antitumor agents. The 2-(3′,4′,5′-trimethoxybenzoyl)-5-aminobenzo­[<i>b</i>]­thiophene moiety was identified as a novel scaffold for the preparation of potent inhibitors of microtubule polymerization acting through the colchicine site of tubulin. The position of the methoxy group on the benzo­[<i>b</i>]­thiophene was important for maximal antiproliferative activity. Structure–activity relationship analysis established that the best activities were obtained with amino and methoxy groups placed at the C-5 and C-7 positions, respectively. Compounds <b>3c</b>–<b>e</b> showed more potent inhibition of tubulin polymerization than combretastatin A-4 and strong binding to the colchicine site. These compounds also demonstrated substantial antiproliferative activity, with IC₅₀ values ranging from 2.6 to 18 nM in a variety of cancer cell lines. Importantly, compound <b>3c</b> (50 mg/kg), significantly inhibited the growth of the human osteosarcoma MNNG/HOS xenograft in nude mice