Influence of genotypes of rs12979860 on SVR in high and low baseline viral load.

a<p>Cochrans and Mantel-Haenszel statistics.</p

Baseline characteristics of genotype I chronic hepatitis C patients treated with PegIFN/RBV and sustained virological response.

<p>BMI: body mass index. ALB: albumin; AST: aspartate transaminase; ALT: alanine transaminase; GGT: gamma-glutamyl transpeptidase; ALP: alkaline phosphatase; SVR: sustained viralogical response; RVR: rapid virological response; EVR: early virological response.</p

Factors predicted ETR to Peg-IFN/RBV treatment in genotype I chronic hepatitis C patients by univariate and multivariate Logistic regression analysis.

<p>Factors predicted ETR to Peg-IFN/RBV treatment in genotype I chronic hepatitis C patients by univariate and multivariate Logistic regression analysis.</p

Factors predicted EVR to Peg-IFN/RBV treatment in genotype I chronic hepatitis C patients by univariate and multivariate Logistic regression analysis.

<p>Factors predicted EVR to Peg-IFN/RBV treatment in genotype I chronic hepatitis C patients by univariate and multivariate Logistic regression analysis.</p

Factors predicted SVR to Peg-IFN/RBV treatment in patients with RVR by univariate and multivariate Logistic regression analysis.

<p>Factors predicted SVR to Peg-IFN/RBV treatment in patients with RVR by univariate and multivariate Logistic regression analysis.</p

Factors predicted SVR to Peg-IFN/RBV treatment in patients without RVR by univariate and multivariate logistic regression analysis.

<p>Factors predicted SVR to Peg-IFN/RBV treatment in patients without RVR by univariate and multivariate logistic regression analysis.</p

Hyperphosphatemia is associated with high mortality in severe burns

<div><p>Introduction</p><p>Phosphate level is often deranged during acute illness, regardless of the presence of kidney injury or not. A few studies described that hypophosphatemia may associated with outcome in patients admitted to the burn unit, but the literatures for hyperphosphatemia is limited. Our study aims to evaluate if hyperphosphatemia, one of the sign of severe tissue damage or kidney injury, will associate with mortality of patients with severe burns.</p><p>Materials and methods</p><p>The study was a post hoc analysis of prospectively collected data from patients admitted to the burn unit between September 2006 and December 2011. Patients were stratified into normophosphatemic or hyperphosphatemic group by baseline plasma phosphate level. The primary endpoint is 90-day mortality.</p><p>Results</p><p>Total 301 patients were included (hyperphosphatemia: n = 52; normophosphatemia: n = 249). The hyperphosphatemic group had lower Glasgow Coma Scale, mean arterial blood pressure, hemoglobin level, albumin, and higher TBSA of burns, APACHE II score, ABSI score, Acute kidney injury (AKI), and creatinine. The 90-day mortality was higher in the hyperphosphatemic group than in the normal group (53.8% vs 18.1%, <i>P</i> < .001) and this difference was still significant when adjusting for several confounding factors (hazard ratio, 2.05; 95% CI, 1.17–3.59). Multivariable Cox analysis showed risk factors of mortality included TBSA of burns, hyperphosphatemia, reduced urine output, and APACHE II score.</p><p>Conclusions</p><p>Our study found in addition to TBSA of burns and inhalation injury, baseline hyperphosphatemia in patients with severe burns is also associated with higher mortality.</p></div

Factors predicted RVR to Peg-IFN/RBV treatment in genotype I chronic hepatitis C patients by univariate and multivariate Logistic regression analysis.

<p>Factors predicted RVR to Peg-IFN/RBV treatment in genotype I chronic hepatitis C patients by univariate and multivariate Logistic regression analysis.</p

Factors predicted SVR to Peg-IFN/RBV treatment in genotype I chronic hepatitis C patients by univariate and multivariate Logistic regression analysis.

<p>UV: univariate logistic regression analysis. MV: multivariate logistic regression analysis.</p><p>OR: odds ratio; CI: confidence interval. Fibrosis stage: Metavir scoring system.</p

<i>IL28B</i> genetic association with sustained virological response in patients with GT1-HCV infection treated with PegIFN/RBV.

<p>Percentages of patients of different genotypes with SVR in eight different SNPs groups were shown. Numbers of patients were also shown below each genotype.</p