Ligand-Enabled Stereoselective β‑C(sp³)–H Fluorination: Synthesis of Unnatural Enantiopure <i>anti</i>-β-Fluoro-α-amino Acids

A quinoline-based ligand was shown to promote palladium-catalyzed β-C­(sp³)–H fluorination for the first time. A range of unnatural enantiopure fluorinated α-amino acids were obtained through sequential β-C­(sp³)–H arylation and subsequent stereoselective fluorination from readily available l-alanine