336 research outputs found
On the scalar nonet in the extended Nambu Jona-Lasinio model
We discuss the lightest scalar resonances, , ,
and in the extended Nambu Jona-Lasinio model. We find
that the model parameters can be tuned, but unnaturally, to accommodate for
those scalars except the . We also discuss problems encountered in
the K Matrix unitarization approximation by using counting technique.Comment: 23 pages 3 eps figures, To appear in Nucl. Phys.
Calculations of Resonance Coupling Constants in the Scalar Sector of the ENJL Model
We derive the scalar resonance coupling constants of resonance chiral theory
from the Extended Nambu Jona-Lasinio model by using heat-kernel expansion.Comment: 7 page
Intensity measurement bend sensors based on periodically tapered soft glass fibers
We demonstrate a novel technique for tapering periodically an all-solid soft glass fiber, consisting of two types of lead silicate glasses, by the use of a focused CO2 laser beam and investigate the bend sensing applications of the periodically-tapered soft glass fiber. Such a soft glass fiber with periodic microtapers could be used to develop promising bend sensors with a sensitivity of -27.75 ”W/m-1 by means of measuring the bend-induced change of light intensity. The proposed bend sensor exhibits a very low measurement error of down to ±1%
CXCR4 Antagonist AMD3100 Modulates Claudin Expression and Intestinal Barrier Function in Experimental Colitis
Ulcerative colitis is a gastrointestinal disorder characterized by local inflammation and impaired epithelial barrier. Previous studies demonstrated that CXC chemokine receptor 4 (CXCR4) antagonists could reduce colonic inflammation and mucosal damage in dextran sulfate sodium (DSS)-induced colitis. Whether CXCR4 antagonist has action on intestinal barrier and the possible mechanism, is largely undefined. In the present study, the experimental colitis was induced by administration of 5% DSS for 7 days, and CXCR4 antagonist AMD3100 was administered intraperitoneally once daily during the study period. For in vitro study, HT-29/B6 colonic cells were treated with cytokines or AMD3100 for 24 h until assay. DSS-induced colitis was characterized by morphologic changes in mice. In AMD3100-treated mice, epithelial destruction, inflammatory infiltration, and submucosal edema were markedly reduced, and the disease activity index was also significantly decreased. Increased intestinal permeability in DSS-induced colitis was also significantly reduced by AMD3100. The expressions of colonic claudin-1, claudin-3, claudin-5, claudin-7 and claudin-8 were markedly decreased after DSS administration, whereas colonic claudin-2 expression was significantly decreased. Treatment with AMD3100 prevented all these changes. However, AMD3100 had no influence on claudin-3, claudin-5, claudin-7 and claudin-8 expression in HT-29/B6 cells. Cytokines as TNF-α, IL-6, and IFN-γ increased apoptosis and monolayer permeability, inhibited the wound-healing and the claudin-3, claudin-7 and claudin-8 expression in HT-29/B6 cells. We suggest that AMD3100 acted on colonic claudin expression and intestinal barrier function, at least partly, in a cytokine-dependent pathway
Effects of resveratrol supplementation on methotrexate chemotherapyâinduced bone loss
Intensive cancer chemotherapy is known to cause bone defects, which currently lack treatments. This study investigated the effects of polyphenol resveratrol (RES) in preventing bone defects in rats caused by methotrexate (MTX), a commonly used antimetabolite in childhood oncology. Young rats received five daily MTX injections at 0.75 mg/kg/day. RES was orally gavaged daily for seven days prior to, and during, fiveâday MTX administration. MTX reduced growth plate thickness, primary spongiosa height, trabecular bone volume, increased marrow adipocyte density, and increased mRNA expression of the osteogenic, adipogenic, and osteoclastogenic factors in the tibial bone. RES at 10 mg/kg was found not to affect bone health in normal rats, but to aggravate the bone damage in MTXâtreated rats. However, RES supplementation at 1 mg/kg preserved the growth plate, primary spongiosa, bone volume, and lowered the adipocyte density. It maintained expression of genes involved in osteogenesis and decreased expression of adipogenic and osteoclastogenic factors. RES suppressed osteoclast formation ex vivo of bone marrow cells from the treated rats. These data suggest that MTX can enhance osteoclast and adipocyte formation and cause bone loss, and that RES supplementation at 1 mg/kg may potentially prevent these bone defects
Systems signatures reveal unique remission-path of Type 2 diabetes following Roux-en-Y gastric bypass surgery
Roux-en-Y Gastric bypass surgery (RYGB) is emerging as a powerful tool for treatment of obesity and may also cause remission of type 2 diabetes. However, the molecular mechanism of RYGB leading to diabetes remission independent of weight loss remains elusive. In this study, we profiled plasma metabolites and proteins of 10 normal glucose-tolerant obese (NO) and 9 diabetic obese (DO) patients before and 1-week, 3-months, 1-year after RYGB. 146 proteins and 128 metabolites from both NO and DO groups at all four stages were selected for further analysis. By analyzing a set of bi-molecular associations among the corresponding network of the subjects with our newly developed computational method, we defined the represented physiological states (called the edge-states that reflect the interactions among the bio-molecules), and the related molecular networks of NO and DO patients, respectively. The principal component analyses (PCA) revealed that the edge states of the post-RYGB NO subjects were significantly different from those of the post-RYGB DO patients. Particularly, the time-dependent changes of the molecular hub-networks differed between DO and NO groups after RYGB. In conclusion, by developing molecular network-based systems signatures, we for the first time reveal that RYGB generates a unique path for diabetes remission independent of weight loss
Complexityâreduced maximumâlikelihood hybrid detection for MIMO systems
Abstract For wireless communications, the multipleâinput multipleâoutput (MIMO) system efficiently makes use of the spectrum and enhances the transmission throughput. In this work, the maximumâlikelihood (ML) detection for the MIMO system is studied, and two ML detection algorithms are first considered for the MIMO system, including the sphere decoding (SD) algorithm and an algorithm based on differential metrics (DMs). Each of the two algorithms has its advantages and disadvantages. The two algorithms are first modified such that they are based on the same signal model. Then, a new ML detection algorithm is proposed for the MIMO system based on the hybrid operation of the two modified algorithms on the tree search process, in which both the branchâandâbound principle and indicative functions are applied to remove unnecessary searches. The proposed algorithm can attain the ML detection with lower average complexity over low and high ranges of signalâtoânoise ratio (SNR), as the authors verify by simulations. The proposed ML detection can also generate soft output, and antiâphase sequences are exploited to further reduce the complexity
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