A Locally Secreted Thyrotropin Variant May Regulate Thyroid Function in Thyroid Inflammatory Disorders

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78105/1/thy.2008.1564.pd

A Fast Fourier Transform Technique for Pricing European Options with Stochastic Volatility and Jump Risk

We consider European options pricing with double jumps and stochastic volatility. We derived closed-form solutions for European call options in a double exponential jump-diffusion model with stochastic volatility (SVDEJD). We developed fast and accurate numerical solutions by using fast Fourier transform (FFT) technique. We compared the density of our model with those of other models, including the Black-Scholes model and the double exponential jump-diffusion model. At last, we analyzed several effects on option prices under the proposed model. Simulations show that the SVDEJD model is suitable for modelling the long-time real-market changes and stock returns are negatively correlated with volatility. The model and the proposed option pricing method are useful for empirical analysis of asset returns and managing the corporate credit risks

The Role of Apoptosis in Thyroid Autoimmunity

There is increasing evidence showing that apoptosis plays a role in the development of the autoimmune thyroid diseases—Hashimoto's (lymphocytic) thyroiditis (HT) and Graves' disease (GD). The immune pathogenesis of HT and GD is not yet fully understood, but evidence points toward several steps. A defect in CD4+CD25+ T regulatory cells breaks the immunological tolerance of the host and induces an abnormal production of cytokines, which facilitates the initiation of apoptosis. Though apoptosis appears to play a role in the pathogenesis of both HT and GD, the mechanisms that mediate these processes appear different. The induction of apoptosis in HT results in the destruction of thyrocytes, while apoptosis in the GD leads to damage of thyroid-infiltrating lymphocytes. The differences in the apoptotic mechanisms produce two very different forms of thyroid autoimmune responses, eventually developing into HT and GD, respectively.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63177/1/thy.2007.0208.pd

Uniaxial and hydrostatic pressure effects in alpha-RuCl3 single crystals via thermal-expansion measurements

We present high-resolution thermal-expansion and specific-heat measurements of single crystalline alpha-RuCl3. An extremely hysteretic structural transition expanding over 100 K is observed by thermal- expansion along both crystallographic axes, which we attribute to a change of stacking sequence of the RuCl3 layers. Three magnetic transitions are observed, which we link to the different stacking sequences. Using our data and thermodynamic relations, we derive the uniaxial and hydrostatic pressure derivatives of all three magnetic transitions. Our results demonstrate that magnetic order should be totally suppressed by very moderate pressures of 0.3 GPa to 0.9 GPa. Finally, we discuss why our results differ from recent hydrostatic pressure measurements and suggest a possible route to reaching the spin-liquid state in alpha-RuCl3.Comment: 6 pages, 3 figure

(E)-3-(9-Anthr­yl)-1-(4-fluoro­phen­yl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one

The C=C double-bond in the title compound, C25H16FN3O, has an E configuration. The dihedral angle between the fluoro­phenyl and triazole rings is 80.57 (2)°