Hierarchically Clustered Representation Learning

The joint optimization of representation learning and clustering in the embedding space has experienced a breakthrough in recent years. In spite of the advance, clustering with representation learning has been limited to flat-level categories, which often involves cohesive clustering with a focus on instance relations. To overcome the limitations of flat clustering, we introduce hierarchically-clustered representation learning (HCRL), which simultaneously optimizes representation learning and hierarchical clustering in the embedding space. Compared with a few prior works, HCRL firstly attempts to consider a generation of deep embeddings from every component of the hierarchy, not just leaf components. In addition to obtaining hierarchically clustered embeddings, we can reconstruct data by the various abstraction levels, infer the intrinsic hierarchical structure, and learn the level-proportion features. We conducted evaluations with image and text domains, and our quantitative analyses showed competent likelihoods and the best accuracies compared with the baselines.Comment: 10 pages, 7 figures, Under review as a conference pape

Decaffeinated Green Coffee Bean Extract Attenuates Diet-Induced Obesity and Insulin Resistance in Mice

This study investigated whether decaffeinated green coffee bean extract prevents obesity and improves insulin resistance and elucidated its mechanism of action. Male C57BL/6N mice (N=48) were divided into six dietary groups: chow diet, HFD, HFD-supplemented with 0.1%, 0.3%, and 0.9% decaffeinated green coffee bean extract, and 0.15% 5-caffeoylquinic acid. Based on the reduction in HFD-induced body weight gain and increments in plasma lipids, glucose, and insulin levels, the minimum effective dose of green coffee bean extract appears to be 0.3%. Green coffee bean extract resulted in downregulation of genes involved in WNT10b- and galanin-mediated adipogenesis and TLR4-mediated proinflammatory pathway and stimulation of GLUT4 translocation to the plasma membrane in white adipose tissue. Taken together, decaffeinated green coffee bean extract appeared to reverse HFD-induced fat accumulation and insulin resistance by downregulating the genes involved in adipogenesis and inflammation in visceral adipose tissue