Insights into the antiviral immunity against grass carp (Ctenopharyngodon idella) reovirus (GCRV) in grass carp

Global fish production from aquaculture has rapidly grown over the past decades, and grass carp shares the largest portion. However, hemorrhagic disease caused by grass carp reovirus (GCRV) results in tremendous loss of grass carp (Ctenopharyngodon idella) industry. During the past years, development of molecular biology and cellular biology technologies has promoted significant advances in the understanding of the pathogen and the immune system. Immunoprophylaxis based on stimulation of the immune system of fish has also got some achievements. In this review, authors summarize the recent progresses in basic researches on GCRV; viral nucleic acid sensors, high-mobility group box proteins (HMGBs); pattern recognition receptors (PRRs), Toll-like receptors (TLRs) and retinoic acid inducible gene I-(RIG-I-) like receptors (RLRs); antiviral immune responses induced by PRRs-mediated signaling cascades of type I interferon (IFN-I) and IFN-stimulated genes (ISGs) activation. The present review also notices the potential applications of molecule genetic markers. Additionally, authors discuss the current preventive and therapeutic strategies (vaccines, RNAi, and prevention medicine) and highlight the importance of innate immunity in long term control for grass carp hemorrhagic disease

Topological structure vulnerability assessment of Shanghai Urban Metro Networks

ABSTRACT Topological structure vulnerability assessment approach for Urban Metro Networks (UMNS) was proposed in order to decrease the impact caused by incidents. Failure scale of stations and sections random failure and target attacks was evaluated. The results show that UMNS is more vulnerable to target attacks on stations than random failure on stations. But UMNS is less vulnerable to target attacks on sections than random failure on sections. Additionally, UMNS is more vulnerable to station failure than sections. It could be concluded as more resources should be put on big transfer stations in UMNS operation management to avoid large scale impacts. The proposed methodology is not intended to predict the occurrence of events but rather to be used a management tool. Results from the evaluation are valuable elements in planning UMNS. They can be used for network planning, further detailed hazard studies, deciding on the arrangement of emergency resources