6 research outputs found
Association of the 894G>T polymorphism in the endothelial nitric oxide synthase gene with risk of acute myocardial infarction
Background: This study was designed to investigate the association of the 894G>T polymorphism in the eNOS gene with risk of acute myocardial infarction (AMI), extent of coronary artery disease (CAD) on coronary angiography, and in-hospital mortality after AMI.
Methods: We studied 1602 consecutive patients who were enrolled in the GEMIG study. The control group was comprised by 727 individuals, who were randomly selected from the general adult population.
Results: The prevalence of the Asp298 variant of eNOS was not found to be significantly and independently associated with risk of AMI (RR = 1.08, 95%CI = 0.77–1.51, P = 0.663), extent of CAD on angiography (OR = 1.18, 95%CI = 0.63–2.23, P = 0.605) and in-hospital mortality (RR = 1.08, 95%CI = 0.29–4.04, P = 0.908).
Conclusion: In contrast to previous reports, homozygosity for the Asp298 variant of the 894G>T polymorphism in the eNOS gene was not found to be associated with risk of AMI, extent of CAD and in-hospital mortality after AM
Clinical characteristics and management of patients with diabetes mellitus and stable coronary artery disease in daily clinical practice. The SCAD-DM Registry
Background: Patients with diabetes mellitus (DM) and coronary artery
disease (CAD) represent a high-risk population, where comorbidities are
common and the progression of coronary heart disease is relatively rapid
and extensive. The present survey, conducted nationwide in a Eurozone
country, Greece, with a properly organized national health system, aimed
to record specific data from a significant number of patients with
diabetes and documented stable CAD (SCAD).
Methods and results: We conducted our survey across the country, in
private and public primary, secondary, and tertiary care centers. A
total of 1900 patients aged 71 +/- 10 years old who suffered from both
DM and chronic coronary syndromes were registered. Of the patients
registered, 574 (30.24%) were women. It was found that 506 (26.6%) of
the 1900 surveyed patients showed typical angina symptoms, while another
560 (29.5%) patients had developed angina-equivalent symptoms according
to their history. Additionally, 324 (17%) patients had atypical
symptoms that could not easily be attributed to existing CAD and the
remaining 510 (26.8%) of the 1900 patients did not exhibit any angina
symptoms during their daily activities. Functional testing for
myocardial ischemia was not performed in 833 patients (43.8%).
Myocardial scintigraphy was the most commonly used noninvasive technique
(644 patients, 34%), while 492 patients (25.9%) had an exercise test
and 159 (8.4%) underwent stress echocardiography.
Conclusion: Real-world data in this specific high-risk population of
diabetic patients with SCAD offer the opportunity to identify and
improve diagnostic and therapeutic practice in the healthcare system of
a European Union country. (C) 2020 Hellenic Society of Cardiology.
Publishing services by Elsevier B.V
Association of the 894G > T polymorphism in the endothelial nitric oxide synthase gene with risk of acute myocardial infarction
Background: This study was designed to investigate the association of
the 894G>T polymorphism in the eNOS gene with risk of acute myocardial
infarction ( AMI), extent of coronary artery disease ( CAD) on coronary
angiography, and in-hospital mortality after AMI.
Methods: We studied 1602 consecutive patients who were enrolled in the
GEMIG study. The control group was comprised by 727 individuals, who
were randomly selected from the general adult population.
Results: The prevalence of the Asp298 variant of eNOS was not found to
be significantly and independently associated with risk of AMI ( RR =
1.08, 95% CI = 0.77-1.51, P = 0.663), extent of CAD on angiography ( OR
= 1.18, 95% CI = 0.63-2.23, P = 0.605) and in-hospital mortality ( RR =
1.08, 95% CI = 0.29-4.04, P = 0.908).
Conclusion: In contrast to previous reports, homozygosity for the Asp298
variant of the 894G>T polymorphism in the eNOS gene was not found to be
associated with risk of AMI, extent of CAD and in-hospital mortality
after AMI