Mandibular exostosis following an epithelial–conjunctival graft: a case report

Observation: A 68-year-old patient presented to us because of the gradual onset of symptoms associated with a mass located on an epithelial–mucosal graft performed approximately 20 years ago. A provisional diagnosis of exostosis was made and the mass was excised under local anesthesia. Comments: Exostosis is defined as a localized benign bone proliferation constituting a sessile nodular bony outgrowth with either a broad base or a peduncle attaching to the parent bone. Some cases of exostosis secondary to the realization of gingival grafts have been reported in the literature. Thus, exostosis should be considered as an unpredictable side effect of this surgical procedure

Nivolumab-induced oral and cutaneous bullous pemphigoid: A case report

Introduction: Nivolumab-induced oral and cutaneous bullous pemphigoid have been rarely reported in the literature. Observations: A 64-year-old male patient was treated with nivolumab for melanoma. He presented with oral lesions in the palatal and gingival mucosal lesions. Nine months after the initiation of nivolumab therapy, a cutaneous bullous pemphigoid was found on his right forearm. The level of anti-BPAG2 (or anti-BP 180) was positive with a rate of 83 AU/mL, thereby confirming the diagnosis of bullous pemphigoid. His oral mucosa, first in the posterolateral area of the palate and then in the gingiva, was affected 3 months later. Histological examination revealed a subepidermal bulla with few eosinophils. Comments: Nivolumab is a novel monoclonal human antibody used to potentiate T cell responses, particularly anti-tumor responses. The first diagnosis considered was lichen planus, and it has been excluded from this study based on histological results. Right from lesion onset after treatment initiation, nivolumab was strongly suspected to cause these mucocutaneous lesions. To investigate the causes and effects of nivolumab-induced oral and cutaneous bullous pemphigoid, it would be necessary to record the regression of these lesions at the end of treatment; however, this is not possible due to ethical reasons. The treatment of lesions primarily involves corticosteroid usage; however, rituximab is also used. Conclusion: Oral surgeons must consider the oral side effects of novel targeted therapies, including those of immunological checkpoint inhibitors

Hereditary angioedema type II and dental extraction: case report and literature review

Introduction: The hereditary angioedema of type II (HAE type II) is a disease which, in the case of invasive acts such as dental extractions, can trigger potentially fatal laryngeal edema. Observation: A 64-year-old man presented to the hospital to perform dental extractions. The anamnesis revealed a history of hereditary angioedema of type II. The National Reference Center for Angioedema (CREAK) recommended a prophylactic protocol before performing this traumatic dental procedure in order to reduce the risk of post-operative edema. Discussion: The HAE type II is under- or misdiagnosed. The literature reports cases of death related to dental procedures in patients unaware of being a carrier of the disease. Conclusion: In case of certain evocative signs (recurrent edema, abdominal pain, family history, etc.), the odontologist must play an active role in the early detection of HAE type II

Le rôle de l’odontologiste dans le cadre du syndrome SAPHO : cas cliniques et revue de la littérature des signes oro-faciaux

Introduction : Le syndrome SAPHO est une affection rare associant des signes ostéo-articulaires et cutanés. C’est une maladie douloureuse et invalidante atteignant plus fréquemment les femmes que les hommes. Les signes cliniques au niveau de la sphère oro-faciale sont rarement évoqués. Observations : Les signes cliniques oro-faciaux évocateurs de ce syndrome ont été rapportés chez un homme de 50 ans et la prise en charge odontotologique d’une femme de 39 ans atteinte d’un syndrome SAPHO est décrite. Discussion : L’odontologiste peut être amené à diagnostiquer un syndrome SAPHO devant certains signes oro-faciaux évocateurs qui font l’objet d’une revue de la littérature. De plus, il apporte sa contribution dans la prise en charge des lésions oro-faciales liées directement au syndrome ou indirectement mais dont le traitement nécessite des précautions particulières ainsi que par la recherche de foyers infectieux avant l’instauration des traitements du syndrome SAPHO. Conclusion : L’odontologiste doit jouer un rôle actif dans la prise en charge du syndrome SAPHO tant sur le versant diagnostique que thérapeutique

Angioedème Héréditaire de type II et extraction dentaire : à propos d’un cas

International audienc

Une pelvis-péritonite causée par une infection par Campylobacter rectus : à propos d’un cas

International audienc

Hereditary angioedema type II and dental extraction: case report and literature review

Introduction: The hereditary angioedema of type II (HAE type II) is a disease which, in the case of invasive acts such as dental extractions, can trigger potentially fatal laryngeal edema. Observation: A 64-year-old man presented to the hospital to perform dental extractions. The anamnesis revealed a history of hereditary angioedema of type II. The National Reference Center for Angioedema (CREAK) recommended a prophylactic protocol before performing this traumatic dental procedure in order to reduce the risk of post-operative edema. Discussion: The HAE type II is under- or misdiagnosed. The literature reports cases of death related to dental procedures in patients unaware of being a carrier of the disease. Conclusion: In case of certain evocative signs (recurrent edema, abdominal pain, family history, etc.), the odontologist must play an active role in the early detection of HAE type II

Calcifying odontogenic cyst: a report of two clinical cases

Introduction: Cystic maxillary lesions are common. In 1962, Gorlin described a rare cystic form termed the calcifying odontogenic cyst (COC) or Gorlin's cyst. Two cases of this form were treated at Bordeaux University Hospital. Observation: The first case was a 17-year-old patient with mandibular odontoma, which had developed over the previous 6 months. Excision was performed under local anesthesia, and the diagnosis of COC was made following pathological analysis. A 6-month follow-up was planned. The second case was a 62-year-old patient with a post-extraction mandibular lesion, which had been evolving for 1 year. Enucleation under local anesthesia led to the diagnosis of COC. No recurrence was observed after 5 years of follow-up. Discussion: COCs are rare lesions affecting mainly the anterior aspect of the mandible. COCs are usually discovered in unforeseen circumstances, and they can be observed as a clinically painless and well-defined oral deformation. Radiological examination often reveals radiolucent and uniloculated lesions, sometimes associated with radiopaque lesions. Pathological analyses are required for final diagnosis. Management is based on complete excision, more or less associated with marsupialization, and requires an annual clinical radiographic monitoring over the next 5 years. Conclusion: COC are rare lesions, usually asymptomatic, whose treatment is based on complete excision. Clinical and radiological follow-up is necessary until complete reossification is achieved