Soft parton resummation in the current region of semi-inclusive deep inelastic scattering

We discuss resummation of large logarithmic terms that appear in the cross-section of semi-inclusive DIS in the case when the final-state hadron follows the direction of the incoming electroweak vector boson in the c.m. frame of the vector boson and the initial-state proton.Comment: Presented at the 8th International Workshop on Deep Inelastic Scattering (DIS2000), Liverpool, U.K., April 2000; 4 pages, 2 fig

Early LQT2 Nonsense Mutation Generates N-Terminally Truncated hERG Channels with Altered Gating Properties by the Reinitiation of Translation

Mutations in the human ether-a-go-go-related gene (hERG) result in long QT syndrome type 2 (LQT2). The hERG gene encodes a K+ channel that contributes to the repolarization of the cardiac action potential. We have previously shown that hERG mRNA transcripts that contain premature termination codon mutations are rapidly degraded by nonsense-mediated mRNA decay (NMD). In this study, we identified a LQT2 nonsense mutation, Q81X, which escapes degradation by the reinitiation of translation and generates N-terminally truncated channels. RNA analysis of hERG minigenes revealed equivalent levels of wild-type and Q81X mRNA while the mRNA expressed from minigenes containing the LQT2 frameshift mutation, P141fs+2X, was significantly reduced by NMD. Western blot analysis revealed that Q81X minigenes expressed truncated channels. Q81X channels exhibited decreased tail current levels and increased deactivation kinetics compared to wild-type channels. These results are consistent with the disruption of the N-terminus, which is known to regulate hERG deactivation. Site-specificmutagenesis studies showed that translation of the Q81X transcript is reinitiated atMet124 following premature termination. Q81X co-assembled with hERG to form heteromeric channels that exhibited increased deactivation rates compared to wild-type channels. Mutant channels also generated less outward current and transferred less charge at late phases of repolarization during ventricular action potential clamp. These results provide new mechanistic insight into the prolongation of the QT interval in LQT2 patients. Our findings indicate that the reinitiation of translation may be an important pathogenic mechanism in patients with nonsense and frameshift LQT2 mutations near the 5′ end of the hERG gene

Getting DNA twist rigidity from single molecule experiments

We use an elastic rod model with contact to study the extension versus rotation diagrams of single supercoiled DNA molecules. We reproduce quantitatively the supercoiling response of overtwisted DNA and, using experimental data, we get an estimation of the effective supercoiling radius and of the twist rigidity of B-DNA. We find that unlike the bending rigidity, the twist rigidity of DNA seems to vary widely with the nature and concentration of the salt buffer in which it is immerged

Radiation Reaction fields for an accelerated dipole for scalar and electromagnetic radiation

The radiation reaction fields are calculated for an accelerated changing dipole in scalar and electromagnetic radiation fields. The acceleration reaction is shown to alter the damping of a time varying dipole in the EM case, but not the scalar case. In the EM case, the dipole radiation reaction field can exert a force on an accelerated monopole charge associated with the accelerated dipole. The radiation reaction of an accelerated charge does not exert a torque on an accelerated magnetic dipole, but an accelerated dipole does exert a force on the charge. The technique used is that originally developed by Penrose for non-singular fields and extended by the author for an accelerated monopole charge.Comment: 11 page

Multivariate Fitting and the Error Matrix in Global Analysis of Data

When a large body of data from diverse experiments is analyzed using a theoretical model with many parameters, the standard error matrix method and the general tools for evaluating errors may become inadequate. We present an iterative method that significantly improves the reliability of the error matrix calculation. To obtain even better estimates of the uncertainties on predictions of physical observables, we also present a Lagrange multiplier method that explores the entire parameter space and avoids the linear approximations assumed in conventional error propagation calculations. These methods are illustrated by an example from the global analysis of parton distribution functions.Comment: 13 pages, 5 figures, Latex; minor clarifications, fortran program made available; Normalization of Hessian matrix changed to HEP standar

Uncertainties of predictions from parton distribution functions II: the Hessian method

We develop a general method to quantify the uncertainties of parton distribution functions and their physical predictions, with emphasis on incorporating all relevant experimental constraints. The method uses the Hessian formalism to study an effective chi-squared function that quantifies the fit between theory and experiment. Key ingredients are a recently developed iterative procedure to calculate the Hessian matrix in the difficult global analysis environment, and the use of parameters defined as components along appropriately normalized eigenvectors. The result is a set of 2d Eigenvector Basis parton distributions (where d=16 is the number of parton parameters) from which the uncertainty on any physical quantity due to the uncertainty in parton distributions can be calculated. We illustrate the method by applying it to calculate uncertainties of gluon and quark distribution functions, W boson rapidity distributions, and the correlation between W and Z production cross sections.Comment: 30 pages, Latex. Reference added. Normalization of Hessian matrix changed to HEP standar

Exotic quark effects on the Higgs sector of the USSM at the LHC

The Higgs sector of the U(1)-extended supersymmetric model is studied with great detail. We calculate the masses of the Higgs bosons at the one-loop level. We also calculate at the one-loop level the gluon-involving processes for the productions and decays of the scalar Higgs bosons of the model at the energy of the CERN Large Hadron Collider (LHC), where the radiative corrections due to the loops of top, bottom, and exotic quarks and their scalar partners are taken into account. We find that the exotic quark and exotic scalar quarks in the model may manifest themselves at the LHC, since the production of the heaviest scalar Higgs boson via gluon fusion processes is mediated virtually by the loops of exotic quark and exotic scalar quarks, for a reasonable parameter set of the model.Comment: 36 pages, 13 figures, JP