1 research outputs found
Synthesis of Cyclic α‑Diazo-β-keto Sulfoxides in Batch and Continuous Flow
Diazo
transfer to β-keto sulfoxides to form stable isolable
α-diazo-β-keto sulfoxides has been achieved for the first
time. Both monocyclic and benzofused ketone derived β-keto sulfoxides
were successfully explored as substrates for diazo transfer. Use of
continuous flow leads to isolation of the desired compounds in enhanced
yields relative to standard batch conditions, with short reaction
times, increased safety profile, and potential to scale up