First Generation E-Rulemaking: An Assessment of Regulatory Agency Websites

We examine 89 websites from federal regulatory agencies in order to evaluate their ease of use for those interested in commenting on or learning about their proposed regulations. We find that while there has been a lot of attention given to second and third generation “e-rulemaking” efforts, agency websites, a first generation innovation, still have considerable room for improvement. Notwithstanding legislative and executive branch efforts to enhance the accessibility of regulatory information on the Internet, our coding of regulatory agency websites reveals considerable variation in the quality of agency websites, with many websites still failing to provide relatively basic features

First Generation E-Rulemaking: An Assessment of Regulatory Agency Websites

We examine 89 websites from federal regulatory agencies in order to evaluate their ease of use for those interested in commenting on or learning about their proposed regulations. We find that while there has been a lot of attention given to second and third generation “e-rulemaking” efforts, agency websites, a first generation innovation, still have considerable room for improvement. Notwithstanding legislative and executive branch efforts to enhance the accessibility of regulatory information on the Internet, our coding of regulatory agency websites reveals considerable variation in the quality of agency websites, with many websites still failing to provide relatively basic features

The Deregulation Deception

President Donald Trump and members of his Administration repeatedly asserted that they had delivered substantial deregulation that fueled positive trends in the U.S. economy prior to the COVID pandemic. Drawing on an original analysis of data on federal regulation from across the Trump Administration’s four years, we show that the Trump Administration actually accomplished much less by way of deregulation than it repeatedly claimed—and much less than many commentators and scholars have believed. In addition, and also contrary to the Administration’s claims, overall economic trends in the pre-pandemic Trump years tended simply to follow economic trends that began years earlier. Why the Trump Administration failed to deliver on its deregulatory goals, notwithstanding the power that U.S. Presidents can exert over the regulatory state, may seem puzzling. The explanation cannot rest merely with the widely held ossification theory that regulatory procedures and judicial review impede attempts to make regulatory change, for the Trump Administration completed many more significant regulatory actions than it did deregulatory ones. We suggest that substantial deregulation is more challenging to achieve than it might seem, demanding strong managerial competencies on the part of a political administration. Furthermore, political leaders do not need to accomplish major deregulation to make it seem as if they have done so. The Trump Administration’s ability to exploit even modest deregulatory actions for symbolic effect provides a case study of a political strategy that we call the deregulation deception—and to which the regulatory state anywhere in the world can be vulnerable. What matters most to some political leaders will be the creation of a perception of dramatic deregulatory change that can be used to claim credit for positive economic trends, just as claims of excessive regulation can be used by politicians to shift blame during periods of economic distress

Recommended Guidelines for the Design of the Federal Docket Management System (FDMS)

The Administration's eRulemaking Initiative will have important implications for access to regulatory information, both for those who work on rules and those organizations and citizens who are affected by rules. These scholars of rulemaking suggest priorities that should guide the eRulemaking Initiative so that all interested parties can better understand and contribute to this common and important mode of policymaking. Collectively,they have studied rulemaking at dozens of regulatory agencies across the federal government. Based ontheir extensive experience using agencies' rulemaking dockets and accessing information from them fortheir research,they believe three principles are vital in designing the forthcoming Federal Docket Management System (FDMS): Consistency in Data: Every effort should be made to keep data fields consistent, both across agencies and over time. Consistency over time is especially important, so that information available in a post-Regulations.Gov era can be matched with earlier information. Flexibility of Search: Users should be able to define their own searches using any of the fields within the docket system. They should also be able to combine different fields. Ease of Access: Users should be able not only to search docket data in a self-defined way, but should be able to download and export search results in commonly used formats, such as comma-separated or Excel or both. Additional signatories of this letter include: Richard N. L. Andrews, Michael Asimow, Bernard W. Bell, Lori Snyder Bennear, Barbara H. Brandon, John Brehm, Gary Bryner, Professor Johnny C. Burris, Mariano-Florentino Cu

High efficiency nanoparticle solution-processed Cu(In,Ga)(S,Se)2 solar cells

Thin film Cu(In,Ga)(S,Se)2-based (generally referred to as CIGS) solar cells represent a promising alternative to conventional crystalline silicon solar cells due to their high efficiencies, reduced cost and better material utilisation. In recent years it has been demonstrated that it is possible to form thin films by annealing nanoparticulate material such that the nanoparticles coalesce to form large grained thin films. In this paper, we present a 13.8 % efficient CIGS solar cell derived from printed nanoparticle inks. The approach was successfully extended to fabricate monolithic devices on larger substrates. These results demonstrate that low-cost, non-vacuum printing of CIGS nanoparticles has great potential to achieve high efficiencies and reduce the performance gap with the more traditional vacuum co-evaporation and sputtering techniques

Analysis and comparison of different selenization routes for nanoparticle ink deposited Cu(In1-xGax)(SeyS1-y)2 solar cells

This paper investigates the effect of using different selenization sources, namely elemental Se and H2Se, on Cu(In1-xGax)(SeyS1-y)2 devices derived from depositions of nanoparticle inks. Nanoparticles used in this synthesis are chalcogenides (e.g. CuInGaS). The effect of the selenization species has a large effect on the performance and electrical properties of these devices. Elemental selenized devices show higher efficiencies (>16%) compared to H2Se processed devices (<12%). Various techniques are used in this study, including Raman spectroscopy, TEM, I-V-T, EQE, admittance spectroscopy and C-V-T to identify the difference in performance between the two selenization methods. Differences are observed in both the bulk and interface properties of the devices

Risk Factors for Hospitalizations Among Older Adults with Gastrointestinal Cancers

Background: Older adults (≥65 years) with gastrointestinal (GI) cancers who receive chemotherapy are at increased risk of hospitalization caused by treatment-related toxicity. Geriatric assessment (GA) has been previously shown to predict risk of toxicity in older adults undergoing chemotherapy. However, studies incorporating the GA specifically in older adults with GI cancers have been limited. This study sought to identify GA-based risk factors for chemotherapy toxicity-related hospitalization among older adults with GI cancers. Patients and methods: We performed a secondary post hoc subgroup analysis of two prospective studies used to develop and validate a GA-based chemotherapy toxicity score. The incidence of unplanned hospitalizations during the course of chemotherapy treatment was determined. Results: This analysis included 199 patients aged ≥65 years with a diagnosis of GI cancer (85 colorectal, 51 gastric/esophageal, and 63 pancreatic/hepatobiliary). Sixty-five (32.7%) patients had ≥1 hospitalization. Univariate analysis identified sex (female), cardiac comorbidity, stage IV disease, low serum albumin, cancer type (gastric/esophageal), hearing deficits, and polypharmacy as risk factors for hospitalization. Multivariable analyses found that patients who had cardiac comorbidity (OR 2.48, 95% CI 1.13-5.42) were significantly more likely to be hospitalized. Conclusion: Cardiac comorbidity may be a risk factor for hospitalization in older adults with GI cancers receiving chemotherapy. Further studies with larger sample sizes are warranted to examine the relationship between GA measures and hospitalization in this vulnerable population

Screaming 'Black' Murder: Crime Fiction and the Construction of Ethnic Identities

A significant segment of crime fiction is concerned with the representation of ethnic identities and may to some extent be considered paradigmatic of the participation of literary texts in discourses on race and minorities. This article explores constructions of ethnic identities in American, British, and South African crime fiction from the 1920s to the early twenty-first century. In particular, the focus will be on such texts in which the ethno-cultural identity of the detective gives special prominence not only to the ethnic particularity of the fictional character itself and of its environs but frequently also to that of its author. Main texts discussed are Rudolph Fisher’s The Conjure Man Dies (1932), Earl Derr Biggers’ The House Without a Key (1925) and The Black Camel (1929), Walter Mosley’s Devil in a Blue Dress (1990) and Little Scarlet (2004) as well as James McClure’s The Gooseberry Fool (1974) and Patrick Neate’s City of Tiny Lights (2005). It is argued that all of these texts have a distinct subversive potential of which the construction of ethnic identities becomes the main vehicle because these identities are the products and the catalysts of the conflicts negotiated in ethnic crime fiction and correlating to ‘reality’

Crk and CrkL adaptor proteins: networks for physiological and pathological signaling

The Crk adaptor proteins (Crk and CrkL) constitute an integral part of a network of essential signal transduction pathways in humans and other organisms that act as major convergence points in tyrosine kinase signaling. Crk proteins integrate signals from a wide variety of sources, including growth factors, extracellular matrix molecules, bacterial pathogens, and apoptotic cells. Mounting evidence indicates that dysregulation of Crk proteins is associated with human diseases, including cancer and susceptibility to pathogen infections. Recent structural work has identified new and unusual insights into the regulation of Crk proteins, providing a rationale for how Crk can sense diverse signals and produce a myriad of biological responses

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase&nbsp;1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation&nbsp;disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age&nbsp; 6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score&nbsp; 652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc&nbsp;= 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N&nbsp;= 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in&nbsp;Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in&nbsp;Asia&nbsp;and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701