5 research outputs found
Zebrafish: a vertebrate tool for studying basal body biogenesis, structure, and function.
- Author
- A Borovina
- A Borovina
- A Dauber
- A Hansen
- A Mahuzier
- A Nasevicius
- A Rodrigues-Martins
- AG Kramer-Zucker
- AK Maurya
- BB Beck
- BM McCluskey
- BP Culver
- C Jones
- C Novorol
- C Stoetzel
- C Stoetzel
- C Zhang
- CC Leitch
- CF Chakarova
- CG Pearson
- CJ Westlake
- CJ Wilkinson
- CL Kilburn
- CP Toret
- D Epting
- DA Dehring
- DF Carlson
- DK Clare
- DP Osborn
- DY Nishimura
- DY Stainier
- EA Otto
- ET Lim
- F Zhou
- FA Ran
- FO Kok
- G Golling
- GG Slaats
- H Khanna
- H Zhao
- IA Drummond
- IJ Winfield
- J Ablain
- J Heasman
- J Yang
- JA Deane
- JA Sayer
- JB Li
- JC Stinchcombe
- JC Talbot
- JD Wood
- JE Lee
- JS Eisen
- JS Nelson
- K Howe
- K Joo
- KD Poss
- KL Pfaff
- KM Nishiguchi
- L He
- L Ma
- LC Keller
- LC Keller
- LE Jao
- LM Baye
- M Breugel van
- M Dona
- M Tsujikawa
- ME Hodges
- MH Al-Hamed
- MP Dekens
- N Pathak
- P Haffter
- P Strnad
- Q Lu
- R Dosch
- R Simms
- RD Allen
- S Geimer
- S Leidel
- S Li
- S Nair
- S Roosing
- SM Glasauer
- SY Tay
- T Avidor-Reiss
- T Yabe
- TJ Dam van
- TJ Near
- V Ravi
- VM Bedell
- W Driever
- X Shu
- Y Chen
- Y Nakazawa
- Y Omori
- YK Durlu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Understanding the role of basal bodies (BBs) during development and disease has been largely overshadowed by research into the function of the cilium. Although these two organelles are closely associated, they have specific roles to complete for successful cellular development. Appropriate development and function of the BB are fundamental for cilia function. Indeed, there are a growing number of human genetic diseases affecting ciliary development, known collectively as the ciliopathies. Accumulating evidence suggests that BBs establish cell polarity, direct ciliogenesis, and provide docking sites for proteins required within the ciliary axoneme. Major contributions to our knowledge of BB structure and function have been provided by studies in flagellated or ciliated unicellular eukaryotic organisms, specifically Tetrahymena and Chlamydomonas. Reproducing these and other findings in vertebrates has required animal in vivo models. Zebrafish have fast become one of the primary organisms of choice for modeling vertebrate functional genetics. Rapid ex-utero development, proficient egg laying, ease of genetic manipulation, and affordability make zebrafish an attractive vertebrate research tool. Furthermore, zebrafish share over 80Â % of disease causing genes with humans. In this article, we discuss the merits of using zebrafish to study BB functional genetics, review current knowledge of zebrafish BB ultrastructure and mechanisms of function, and consider the outlook for future zebrafish-based BB studies
The elegans of spindle assembly
- Author
- A Akhmanova
- A Dammermann
- A Dammermann
- A Dammermann
- A Desai
- A Khodjakov
- A Khodjakov
- A Merdes
- A Rodrigues-Martins
- AA Cuenca
- AC Groen
- AH Sathananthan
- AL Knowlton
- AL Schlaitz
- AM Mulder
- AM Saunders
- AR Barr
- AS Kashina
- AW Hunter
- B Bowerman
- B Byers
- B Sonnichsen
- BR Oakley
- C Bamba
- C Gueth-Hallonet
- C Kozlowski
- C Lloyd
- C Segbert
- C Wiese
- CA Kemp
- CA Kemp
- CA Moores
- CA Schatz
- CE Oakley
- CE Walczak
- CE Walczak
- CJ Malone
- CR Cowan
- CS Chan
- D Chretien
- D Job
- DG Albertson
- DG Albertson
- DJ Schmidt
- DL Gard
- DL Gard
- DM Glover
- DR Hamill
- DR Kellogg
- DW Buster
- DY Kim
- E Bullitt
- E Hannak
- E Hannak
- E Nogales
- E Rebollo
- Eileen OâToole
- EM Mandelkow
- ET OâToole
- ET OâToole
- F Zhu
- FJ McNally
- FR Bischoff
- G Gopalan
- G Goshima
- G Yang
- Garrett Greenan
- GC Rogers
- GJ Brouhard
- H Bringmann
- H Huang
- HJ Matthies
- HP Erickson
- HY Yang
- HY Yang
- I Arnal
- I Vernos
- J Azimzadeh
- J Helenius
- J Howard
- J Howard
- J Kleylein-Sohn
- J Loncarek
- J Monen
- J Pecreaux
- J Powers
- JC Labbe
- JD Bishop
- JE Kimble
- JE Sulston
- JJ Hartman
- JM Bellanger
- JM Scholey
- JM Schumacher
- JM Schumacher
- JR Hughes
- JW Kerssemakers
- K Afshar
- K Kinoshita
- K McNally
- K Oegema
- K Oegema
- KC Slep
- KF OâConnell
- KF OâConnell
- KL McNally
- L Pelletier
- L Pelletier
- LA Amos
- LR Matthews
- M Bettencourt-Dias
- M Bornens
- M Boxem
- M Delattre
- M Galli
- M Glotzer
- M Kirkham
- M Moritz
- M Moritz
- M Moritz
- M Schuh
- M Srayko
- M Srayko
- M Srayko
- M Srayko
- M Voet van der
- MA Miller
- MA Miller
- Martin Srayko
- MF Tsou
- MH Bre
- MH Song
- MJ Lee
- ML Ellefson
- MP Rout
- MW Kirschner
- N Le Bot
- N Ozlu
- N Peel
- N Portier
- N Shiina
- N Wolf
- OJ Gruss
- P Askjaer
- P Gonczy
- P Kalab
- P Strnad
- PD Andrews
- PD Andrews
- PL Sadler
- R Basto
- R Giet
- R Habedanck
- R Heald
- R Tournebize
- RD Vale
- RK Herman
- RN Gunawardane
- RS Kochanski
- S Clark-Maguire
- S Clark-Maguire
- S Faruki
- S Lawo
- S Leidel
- S Leidel
- S Moutinho-Pereira
- S Ruchaud
- S Strome
- S Ward
- S Ward
- SF Bakhoum
- SK Dutcher
- SL Jaspersen
- SL Kline-Smith
- SM Murphy
- SM Wignall
- SS Andersen
- SS Andersen
- SW Grill
- SW Grill
- SZ Wang
- T Mitchison
- T Muller-Reichert
- T Wittmann
- T Yabe
- Thomas MĂŒller-Reichert
- TJ Keating
- TL Megraw
- U Rath
- US Tulu
- W Lan
- WE Theurkauf
- WF Marshall
- X Zhang
- Y Nakazawa
- Y Zheng
- ZY Liang
- Publication venue
- SP BirkhÀuser Verlag Basel
- Publication date
- 01/01/2010
- Field of study
The Caenorhabditis elegans one-cell embryo is a powerful system in which to study microtubule organization because this large cell assembles both meiotic and mitotic spindles within the same cytoplasm over the course of 1Â h in a stereotypical manner. The fertilized oocyte assembles two consecutive acentrosomal meiotic spindles that function to reduce the replicated maternal diploid set of chromosomes to a single-copy haploid set. The resulting maternal DNA then unites with the paternal DNA to form a zygotic diploid complement, around which a centrosome-based mitotic spindle forms. The early C. elegans embryo is amenable to live-cell imaging and electron tomography, permitting a detailed structural comparison of the meiotic and mitotic modes of spindle assembly
Oral Cytokeratins in Health and Disease
- Author
- Alberts B Johnson A, Lewis J, Raff M, Roberts K, Walter P.
- Bancroft JD Cook HC, Stirling RW.
- Barak V Goike H, Panaretakis KW, Einarsson R.
- Berkovitz BKB Holland GR, Moxham BJ.
- Bowden PE Haley JL, Kansky A, Rothnagel, JA, Jones DO, Turner RJ.
- Bragulla HH Homberger DG.
- Browne RM
- Butler RT Spector ME, Thomas D, McDaniel AS, McHugh JB.
- Coulombe PA Bousquet O, Ma L, Yamada S, Wirtz D.
- Crivelini MM de AraĂșjo VC, de Sousa SO, de AraĂșjo NS.
- Cummings TJ Dodd LG, Eedes CR, Klintworth GK.
- Dale BA Salonen J, Jones AH.
- Dardick I.
- Dokal I Vulliamy T, Mason P, Bessler M.
- Draeger A et al.
- Fletcher CDM.
- Fraser RD MacRae TP, Parry DA, Suzuki E.
- Garant PR.
- Geiger S et al.
- Geisler N Weber K.
- Grando SA.
- Green KJ Bohringer M, Gocken T, Jones JCR.
- Gu LH Coulombe PA.
- Hofmeier J.
- Irvine AD McLean WHI.
- Kirfel J Magin TM, Reichelt J,
- Kumar GS.
- Lane EB Mc Lean WH.
- Laskin WB Epithelioid MM.
- Lindberg K Rheinwald JG.
- Linder S.
- McLean et al.
- Miettinen M Fanburg-Smith JC, Virolainen M, Shmookler BM, Fetsch JF.
- Moll R Franke WW, Schiller DL, Geiger B, Krepler R.
- Moll R Langbein MDL.
- Nanci A.
- Nanda KDS Ranganathan K, Devi U, Joshua E.
- Neville BW Damm DD, Allen CM, Bouquot JE.
- Nikitakis NG et al.
- Oshima RG.
- Parry DA Strelkov SV, Burkhard P, Aebi U, Herrmann H.
- Pearse AGE.
- Pekny M Lane EB.
- Presland RB Dale BA.
- Rajendran R Sivapathasundharam B.
- Regezi JA Sciubba JJ, Jordan RC.
- Sakuntabhai A et al.
- Schweizer J et al.
- Shapiro SS Seiberg M, Cole CA.
- Shear M Speight P.
- Shetty S Gokul S.
- Smith FJD et al.
- Smith TA Machen SK, Fisher C, Goldblum JR.
- Steinert PM.
- Stoll C Stollenwerk C, Riedeger D, Mittermeyer C, Alfer J.
- Strnad P et al.
- Surekharamulu Kale AD, Hallikerimath S, Kotrashetti V.
- Tudor D Locke M, Owen-Jones E, Mackenzie IC.
- Warnakulasuriya S Tilakaratne WM.
- Weiss SH Goldblum JR.
- Wilson NJ et al.
- Publication venue
- 'Jaypee Brothers Medical Publishing'
- Publication date
- Field of study
Parthenogenesis in insects: the centriole renaissance
- Author
- A Briedis
- A Courtois
- A Debec
- A Debec
- A Jord Al
- A Khodjakov
- A Paffoni
- A Paoletti
- A Pimenta-Marques
- A Rodrigues-Martins
- A Rodrigues-Martins
- A Shukla
- A Thielsch
- A Tyler
- A Wilde
- AF Huettner
- AF Severson
- AH Sathananthan
- AH Sathananthan
- AH Sathananthan
- AJ Holland
- AM Lambert
- AO Vershinina
- AP Mahowald
- AW Moy
- B Baccetti
- B Baccetti
- B Baccetti
- B Buendia
- B Mantovani
- B Maro
- B Saint Phalle de
- B Sullender
- BA Afzelius
- BD Vitre
- BGM Jamieson
- BP Culver
- BR Brinkley
- BR Oakley
- BT Wakimoto
- C Arquint
- C Gonzalez
- C Gueth-Hallonet
- C Jura
- C Klotz
- C Palévody
- C Rispe
- CG Pearson
- CI Dix
- CJ Malone
- CR Simerly
- CS Fong
- CT Anderson
- CV Sartain
- D Gogendeau
- D Izquierdo
- D Kitagawa
- D Mazia
- D Pellman
- D Szollosi
- D Szollosi
- D Zyss
- DA Brito
- DA Lerit
- DF Went
- DJ Forbes
- DJ Innes
- DL Trudgill
- DM Phillips
- E Beneden van
- E Hatch
- E Karsenti
- E Paccagnini
- E Suomalainen
- E Suomalainen
- E Suomalainen
- EA Nigg
- EA Nigg
- EA Nigg
- EA Nigg
- EH Hinchcliffe
- EP Fried de
- EP Hildreth
- ER Dirksen
- ER Dirksen
- ET OâToole
- F Nedelec
- F Paoli
- F Tournier
- F Verde
- FG Agircan
- FJ Nedelec
- G Bell
- G Callaini
- G Callaini
- G Callaini
- G Callaini
- G Goshima
- G Manandhar
- G Manandhar
- G Manandhar
- G Mirzaghaderi
- G Schatten
- G Schatten
- G Sluder
- G Sluder
- G Sluder
- G Sluder
- G Tavosanis
- GA Pihan
- GA Zorn
- GE Heimpel
- GK Davis
- GW Schuett
- H Fritz-Niggli
- H Nagano
- H Schatten
- H Schatten
- H Schatten
- HJG Matthies
- HL Carson
- HR Dawe
- I Belecz
- I Bennabi
- J Azimzadeh
- J Azimzadeh
- J Azimzadeh
- J Borrego-Pinto
- J Dumont
- J Fu
- J Fu
- J Gopalakrishnan
- J Januschke
- J Loeb
- J Loncarek
- J Reina
- J Wong
- JB Dictenberg
- JC Simon
- JH Henson
- JM Cook
- JW Raff
- JW Wright
- K Crasta
- K Fahmy
- K Hara
- K Sekiné
- KA Feldheim
- KH Kato
- KS McKim
- L Pelletier
- L Pelletier
- LP Pijnacker
- M Bettencourt-Dias
- M Bettencourt-Dias
- M Bettencourt-Dias
- M Bornens
- M Bornens
- M Bornens
- M Bornens
- M Breugel van
- M BuĆiÄ
- M Carmo Avides do
- M Delattre
- M FriedlÀnder
- M Gottardo
- M Gottardo
- M Gottardo
- M Gottardo
- M Gottardo
- M Hirono
- M Kirkham
- M Kloc
- M Martinez-Campos
- M Piel
- M Salinas-Saavedra
- M Schuh
- M Ćuksza
- MC Gould
- ME Crowder
- MF Tsou
- MF Tsou
- MG Giansanti
- MG Kramer
- MG Riparbelli
- MG Riparbelli
- MG Riparbelli
- MG Riparbelli
- MG Riparbelli
- MG Riparbelli
- MG Riparbelli
- MG Riparbelli
- MG Riparbelli
- MG Riparbelli
- MG Riparbelli
- MG Riparbelli
- MG Riparbelli
- MH Song
- MI Sachs
- MM Krioutchkova
- MR Mahjoub
- MV Nachury
- MW Olsen
- MY Tsai
- N Paweletz
- N Peel
- N Trieselmann
- NJ Ganem
- NR Stevens
- NS Dzhindzhev
- O Marescalchi
- O Marescalchi
- OJ Gruss
- P Favard
- P Guichard
- P Gönczy
- P Harris
- P Meraldi
- P Michalik
- P Sarvella
- P Stenberg
- P Strnad
- P Wadsworth
- PA Coelho
- PC Watts
- PDN Hebert
- PE King
- PG Calarco
- PG Wilson
- PL Alvey
- PL Chavali
- PM Ferree
- PR Clarke
- PT Conduit
- PT Conduit
- PT Conduit
- Q-Y Sun
- R Balczon
- R Basto
- R Basto
- R Dallai
- R Dallai
- R Dallai
- R Eisman
- R Heald
- R Heald
- R Kuriyama
- R Seitz
- R Stouthamer
- R Stouthamer
- RD Allen
- RE Carazo-Salas
- RG Anderson
- RG Reynolds
- RJ Kallenbach
- RJ Kallenbach
- RJ Kallenbach
- RL Blackman
- RL Blackman
- RR Snook
- RR Snook
- RR Snook
- RV Dippel
- RY Lamb
- S Blachon
- S Blachon
- S Lawo
- S Terra La
- SA Godinho
- SA Godinho
- SC Jana
- SE Asker
- SJ Doxsey
- SJ Vidwans
- SK Dutcher
- T Avidor-Reiss
- T Avidor-Reiss
- T Boveri
- T Boveri
- T Cavalier-Smith
- T Kaneuchi
- T Magnuson
- T Mikeladze-Dvali
- T Miki-Noumura
- T Schwander
- TH Morgan
- TL Karr
- TVM Groot
- U Nur
- U Scheer
- U Stepinska
- U Tram
- V Mennella
- VL Horner
- W Booth
- W Flemming
- WA Anderson
- WC Zimmerman
- WE Theurkauf
- WF Marshall
- WJ Wang
- X-W Li
- Y Heifetz
- Y Iwao
- Y Iwao
- Y Iwao
- Y Iwao
- Y Shirato
- Y Uetake
- Y Uetake
- Z Carvalho-Santos
- Z Carvalho-Santos
- ZA Novak
- ZA Novak
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Building a new organism usually requires the contribution of two differently shaped haploid cells, the male and female gametes, each providing its genetic material to restore diploidy of the new born zygote. The successful execution of this process requires defined sequential steps that must be completed in space and time. Otherwise, development fails. Relevant among the earlier steps are pronuclear migration and formation of the first mitotic spindle that promote the mixing of parental chromosomes and the formation of the zygotic nucleus. A complex microtubule network ensures the proper execution of these processes. Instrumental to microtubule organization and bipolar spindle assembly is a distinct non-membranous organelle, the centrosome. Centrosome inheritance during fertilization is biparental, since both gametes provide essential components to build a functional centrosome. This model does not explain, however, centrosome formation during parthenogenetic development, a special mode of sexual reproduction in which the unfertilized egg develops without the contribution of the male gamete. Moreover, whereas fertilization is a relevant example in which the cells actively check the presence of only one centrosome, to avoid multipolar spindle formation, the development of parthenogenetic eggs is ensured, at least in insects, by the de novo assembly of multiple centrosomes. Here, we will focus our attention on the assembly of functional centrosomes following fertilization and during parthenogenetic development in insects. Parthenogenetic development in which unfertilized eggs are naturally depleted of centrosomes would provide a useful experimental system to investigate centriole assembly and duplication together with centrosome formation and maturation
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
- Author
- Abdelmohsen K
- Abe A
- Abedin MJ
- Abeliovich H
- Acevedo Arozena A
- Adachi H
- Adams CM
- Adams PD
- Adeli K
- Adhihetty PJ
- Adler SG
- Agam G
- Agarwal R
- Aghi MK
- Agnello M
- Agostinis P
- Aguilar PV
- Aguirre-Ghiso J
- Airoldi EM
- Ait-Si-Ali S
- Akematsu T
- Akporiaye ET
- Al-Rubeai M
- Albaiceta GM
- Albanese C
- Albani D
- Albert ML
- Aldudo J
- AlgĂŒl H
- Alirezaei M
- Alloza I
- Almasan A
- Almonte-Beceril M
- Alnemri ES
- Alonso C
- Altan-Bonnet N
- Altieri DC
- Alvarez S
- Alvarez-Erviti L
- Alves S
- Amadoro G
- Amano A
- Amantini C
- Ambrosio S
- Amelio I
- Amer AO
- Amessou M
- Amon A
- An Z
- Anania FA
- Andersen SU
- Andley UP
- Andreadi CK
- Andrieu-Abadie N
- Anel A
- Ann DK
- Anoopkumar-Dukie S
- Antonioli M
- Aoki H
- Apostolova N
- Aquila S
- Aquilano K
- Araki K
- Arama E
- Aranda A
- Araya J
- Arcaro A
- Arias E
- Arimoto H
- Ariosa AR
- Armstrong JL
- Arnould T
- Arsov I
- Asanuma K
- Askanas V
- Asselin E
- Atarashi R
- Atherton SS
- Atkin JD
- Attardi LD
- Auberger P
- Auburger G
- Aurelian L
- Autelli R
- Avagliano L
- Avantaggiati ML
- Avrahami L
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- Belaid A
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- Bertolotti A
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- Bolino A
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- Campanella M
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- Chen YG
- Chen YH
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- Chen Z
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- Cheng A
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