Relationship between financial indicators of a company and the ERP-system implementation costs

© 2014, Mediterranean Center of Social and Educational Research. All rights reserved. The article investigates the issues of implementation of ERP-systems in large Russian companies. The authors put forward and substantiated the hypothesis about the positive impact of implementation of ERP-systems in the company's growth. For the purposes of this study, 30 large Russian companies that had implemented SAP R/3 o;r SAP ERP modules have been observed. Obtained result shows, that implementation of the ERP-system or its individual modules makes a positive impact in the company's growth, measured by the total assets indicator

Key performance indicators in corporate finance

© 2015, Asian Social Science. All rights reserved. The relevance of the study caused by the necessity to assess the impact of KPI system for growth of shareholders welfare and the satisfaction of the interests of other stakeholders. KPI concept suggests widespread use of these factors as measures of internal and external efficiency, as well as an incentive for management to meet the strategic objectives of the company. The article examines the influence of key performance indicators on the value of Russian companies. We used the following tools of econometric research: content analysis and econometric modeling to conduct the study

Small and medium businesses informatization managment: Main trends of development in Russia

© 2014, Mediterranean Journal of Social Sciences. All right reserved. The system architecture of a small business must also provide financial management, personnel, procurement, manufacturing, sales, etc. Due to the fact that in small and medium-sized businesses there are combined functions of ownership and management, information management system must provide accurate and up-to-date information about finance and manufacturing resources. We have reviewed the structure of the Russian market of software products for small and mediumsized businesses and explained the leading position of some companies. We conducted a survey of SEOs of SME and employees of the companies ERP systems vendors, who showed quite a symmetric assessment of development informatization of SME

Key performance indicators in internal control

© Medwell Journals, 2017. This study describes some of the approaches to the problem of establishing an effective system of internal financial control structures aimed at rational use of material, labor and financial resources in the conditions of crisis in the global economy. In the study in particular, we hypothesized about the need to use key performance indicators in the internal financial control system. The KPI system is integrated in the modern concept of corporate finance in particular VBM. In this regard in the study, we constructed an econometric model of the relationship between financial performance and economic value added for the purpose of identifying which particular KPI may serve as reference points for the internal financial control department

Novel potent pyridoxine-based inhibitors of AChE and BChE, structural analogs of pyridostigmine, with improved in vivo safety profile

© 2016 Elsevier LtdWe report a novel class of carbamate-type ChE inhibitors, structural analogs of pyridostigmine. A small library of congeneric pyridoxine-based compounds was designed, synthesized and evaluated for AChE and BChE enzymes inhibition in vitro. The most active compounds have potent enzyme inhibiting activity with IC50 values in the range of 0.46–2.1 μM (for AChE) and 0.59–8.1 μM (for BChE), with moderate selectivity for AChE comparable with that of pyridostigmine and neostigmine. Acute toxicity studies using mice models demonstrated excellent safety profile of the obtained compounds with LD50 in the range of 22–326 mg/kg, while pyridostigmine and neostigmine are much more toxic (LD50 3.3 and 0.51 mg/kg, respectively). The obtained results pave the way to design of novel potent and safe cholinesterase inhibitors for symptomatic treatment of neuromuscular disorders

Pathophysiological Mechanisms of Antipsychotic-Induced Parkinsonism

Among neurological adverse reactions in patients with schizophrenia treated with antipsychotics (APs), drug-induced parkinsonism (DIP) is the most common motility disorder caused by drugs affecting dopamine receptors. One of the causes of DIP is the disruption of neurotransmitter interactions that regulate the signaling pathways of the dopaminergic, cholinergic, GABAergic, adenosinergic, endocannabinoid, and other neurotransmitter systems. Presently, the development mechanisms remain poorly understood despite the presence of the considered theories of DIP pathogenesis

Ритмическая транскраниальная магнитная стимуляция в терапии нейропатической боли, сопровождающейся коморбидной депрессией: обзор эффективных параметров лечебных протоколов

Neuropathic pain affects 7 % of the general population worldwide, it is often resistant to analgesic treatments and is complicated with depressive states in 57–65 % of this patients’ cohort. Ongoing research of current therapeutic approaches, including repetitive transcranial magnetic stimulation (rTMS) use in neuropathic pain and depression, grants new data about the details of treatment protocols’ designs. The aim of our literature review was to evaluate those parameters of the treatment protocols which proved significant efficacy in the management of the neuropathic pain with comorbid depression.Focusing on the Scopus, Elsevier and PubMed databases search, we have found 639 peer‑review articles. 23 studies have been included into the data analysis, whereas others were excluded based on their heterogeneous study design. Across the data analysis we evaluated such rTMS parameters as the type of a coil, type of stimulation area, locus of gained evoked motor potential, amplitude of stimulation, duration of session, frequency/number of sessions per day/month, tie duration between sessions, number and frequency of trains, amount and frequency of pulses containing and efficacy of treatment. Those studies that performed repetitive transcranial magnetic stimulation using the figure‑of‑8 coil over the M1 brain area, for 10 or more daily sessions with duration from 7 up to 40 minutes, of 10–20 Hz frequency, intensity 80–90 % of resting motor threshold and total pulses number over 1500 per session demonstrated the greater efficacy in pain level decrease and depression scores reduction among neuropathic pain patients with comorbid depression. Conducting an additional maintenance phase of treatment prolonged the therapeutic effect of the course.Based on the data review, the parameters of the most efficient rTMS protocols’ designs in management of patients with neuropathic pain and comorbid depression have been revealed. Further research requires investigation of other promising indicators of rTMS efficacy use in neuropathic pain with comorbid depression, such as stimulation over multiple brain areas, the duration/timing of additional maintenance phase of treatment, and the figure‑of‑8 coil orientation options.По общемировым данным, нейропатическая боль встречается у 7 % населения и в 57–65 % случаев сопровождается коморбидной депрессией, что, в свою очередь, усугубляет течение болезни и ухудшает качество жизни пациентов. Ритмическая транскраниальная магнитная стимуляция (рТМС) представляет собой неинвазивный нефармакологический метод терапии депрессии,  также способный помочь пациентам облегчить восприятие нейропатической боли. Представлен обзор результатов применения протоколов рТМС, продемонстрировавших эффективность в терапии клинических состояний, сопровождающихся нейропатической болью с коморбидной депрессией.Исследуя базы данных Scopus, Elsevier и PubMed , мы обнаружили 639 статей, из которых в соответствии с критериями включения были отобраны 23. Оценке подверглись данные о клинической эффективности рТМС в терапии нейропатической боли и коморбидной депрессии в зависимости от параметров протокола стимуляции, включая тип катушки, целевую зону мозга, продолжительность сеанса, частоту/количество сеансов в день/месяц, а также межсеансовые интервалы, число и частоту импульсов.Протоколы, показавшие наибольшую эффективность, включали такие параметры, как использование катушки в форме восьмерки, направленной на первичную моторную зону (M1), применение рТМС в течение не менее 10 ежедневных сеансов, использование высокочастотной стимуляции (10–20 Гц) с интенсивностью 80–90 % от порога моторного ответа, с длительностью сессии от 7 до 40 мин и с общим количеством импульсов не менее 1500 за сеанс. Проведение дополнительной поддерживающей фазы лечения продлевало терапевтический эффект курса.Результаты анализа данных литературы предполагают, что определенная комбинация параметров стимуляции может быть более эффективной для терапии нейропатической боли, сопровождающейся коморбидной депрессией, тем самым открывая новые возможности терапии для пациентов с резистентными состояниями, плохо поддающимися фармакологической коррекции. Рассмотрение параметров протоколов рТМС выявило необходимость дальнейшего изучения метода в лечении указанных клинических состояний не только в рамках репликации данных, но и для анализа таких дополнительных параметров, как последовательная или одновременная стимуляция нескольких областей мозга, угол поворота катушки, а также для уточнения времени поддерживающей фазы стимуляции

Small and medium businesses informatization managment: Main trends of development in Russia

© 2014, Mediterranean Journal of Social Sciences. All right reserved. The system architecture of a small business must also provide financial management, personnel, procurement, manufacturing, sales, etc. Due to the fact that in small and medium-sized businesses there are combined functions of ownership and management, information management system must provide accurate and up-to-date information about finance and manufacturing resources. We have reviewed the structure of the Russian market of software products for small and mediumsized businesses and explained the leading position of some companies. We conducted a survey of SEOs of SME and employees of the companies ERP systems vendors, who showed quite a symmetric assessment of development informatization of SME

Problematic aspects of corporate tax risk empirical analysis

© 2015, Asian Social Science. All rights reserved. Theoretically corporate tax risk is defined as the probability of deviations of the tax burden from the planned values. From the standpoint of tax law there are much more taxation risk factors. The revenue authorities considered as a risk factor not only the amount of the tax burden, but also its fluctuation relative to the average industry value. Besides these, taxation risk factors are: low level of the average wage in a corporation, losses in the company’s several tax periods, increase of costs, compared with revenues exceeding the growth rate of tax deductions for VAT, the inconsistency of profitability indicators to average industry values, etc. So, the following question arises: whether the selection of these factors in terms of their relationship to the cost management is justified? Do the taxes and taxation risk in the value of a corporation is essentially? This article is devoted to research these problematical issues

Key performance indicators in corporate finance

© 2015, Asian Social Science. All rights reserved. The relevance of the study caused by the necessity to assess the impact of KPI system for growth of shareholders welfare and the satisfaction of the interests of other stakeholders. KPI concept suggests widespread use of these factors as measures of internal and external efficiency, as well as an incentive for management to meet the strategic objectives of the company. The article examines the influence of key performance indicators on the value of Russian companies. We used the following tools of econometric research: content analysis and econometric modeling to conduct the study