Confirmation of out-of-State Arbitration Awards under Maryland\u27s Uniform Arbitration Act

This Article examines the difficulties inherent in the confirmation of out-of-state arbitration awards under the Maryland Uniform Arbitration Act. The author recommends that either the General Assembly amend the Act to provide expressly for such confirmations in Maryland courts, or the courts, in the absence of such legislation, nevertheless should allow confirmation of such awards

A Roadmap through Malice, Actual or Implied: Punitive Damages in Torts Arising out of Contract in Maryland

The distinction between tort and tort arising out of contract is becoming blurred where awards of punitive damages are sought. The article analyzes torts arising out of contract and the present approach of the Maryland courts to malice, the key element governing the recovery of punitive damages. The author suggests that the conduct, and not the technical term of the wrongful act, should dictate whether a plaintiff may recover punitive damages

Confirmation of out-of-State Arbitration Awards under Maryland\u27s Uniform Arbitration Act

This Article examines the difficulties inherent in the confirmation of out-of-state arbitration awards under the Maryland Uniform Arbitration Act. The author recommends that either the General Assembly amend the Act to provide expressly for such confirmations in Maryland courts, or the courts, in the absence of such legislation, nevertheless should allow confirmation of such awards

A Roadmap through Malice, Actual or Implied: Punitive Damages in Torts Arising out of Contract in Maryland

The distinction between tort and tort arising out of contract is becoming blurred where awards of punitive damages are sought. The article analyzes torts arising out of contract and the present approach of the Maryland courts to malice, the key element governing the recovery of punitive damages. The author suggests that the conduct, and not the technical term of the wrongful act, should dictate whether a plaintiff may recover punitive damages

An integrated genomic analysis of human glioblastoma Multiforme

Glioblastoma multiforme ( GBM) is the most common and lethal type of brain cancer. To identify the genetic alterations in GBMs, we sequenced 20,661 protein coding genes, determined the presence of amplifications and deletions using high- density oligonucleotide arrays, and performed gene expression analyses using next- generation sequencing technologies in 22 human tumor samples. This comprehensive analysis led to the discovery of a variety of genes that were not known to be altered in GBMs. Most notably, we found recurrent mutations in the active site of isocitrate dehydrogenase 1 ( IDH1) in 12% of GBM patients. Mutations in IDH1 occurred in a large fraction of young patients and in most patients with secondary GBMs and were associated with an increase in overall survival. These studies demonstrate the value of unbiased genomic analyses in the characterization of human brain cancer and identify a potentially useful genetic alteration for the classification and targeted therapy of GBMs.Ludwig Fund for Cancer ResearchNIH[CA121113]NIH[NS052507]NIH[CA43460]NIH[CA57345]NIH[CA62924]NIH[CA09547]NIH[5P50-NS-20023]NIH[CA108786]NIH[CA11898]Pew Charitable TrustsPediatric Brain Tumor Foundation InstituteHirschhorn FoundationAlex`s Lemonade Stand FoundationAmerican Brain Tumor AssociationAmerican Society of Clinical OncologyBrain Tumor Research FundBeckman Coulter Corporatio

Evolution of genes and genomes on the Drosophila phylogeny

Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species

Evolution of genes and genomes on the Drosophila phylogeny

Affiliations des auteurs : cf page 216 de l'articleInternational audienceComparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species