KEYNOTE ADDRESS: On the Binding Biases of Time

Lance Strate is Professor of Communication and Media Studies at Fordham University, and Executive Director of the Institute of General Semantics. He is a Past President of the New York State Communication Association, and a recipient of NYSCA\u27s John F. Wilson Award. He is a founder and Past President of the Media Ecology Association, and author of Echoes and Reflections: On Media Ecology as a Field of Study. This is the text of his Keynote Address presented at the 67th Annual Conference of the New York State Communication Association, Ellenville, NY, October 23-25, 2009

Casino Drink Policies: Limiting Third-Party Liability

In their efforts to provide an atmosphere or hospitality to their casino customers, many operators will provide complimentary alcoholic beverage service. This practice is fraught with liability, particularly in venues outside of Nevada. Conscientious operators must take every precaution to mitigate the possibility of lawsuit

Economic burden of diverticular disease : an observational analysis based on real world data from an Italian region

INTRODUCTION: Diverticular disease (DD), a herniation of the colonic mucosa through the muscle layer, covers a wide variety of conditions associated with the presence of diverticula in the colon. The most serious form is an acute episode of diverticulitis, which can lead to hospitalization and surgery with various types of consequences. The main aim of this study is to evaluate the economic burden of hospitalizations arising from acute episodes of diverticulitis using data from the administrative databases used in the Marche region in Italy and, as a secondary objective of this real-world data analysis, to study patient outcome variables following initial hospitalization for diverticulitis. METHOD: A deterministic linkage was performed at individual user level between the different administrative sources of the Marche region through anonymous ID number for a period of analysis between 1 January, 2008 and 31 December, 2014. We enrolled all patients with at least one hospitalization for "diverticulitis of the colon without mention of haemorrhage" (ICD-9-CM code 562.11) or "diverticulitis of the colon with haemorrhage" (ICD-9-CM code 562.13) as primary or secondary diagnosis. For each patient we assessed the cost of hospitalization, of medicines and of specialist services considering a time-scale of one year or cohort analysis 365days after first admission. RESULTS: The total number of residents in the Marche region who had at least one hospitalization for diverticulitis in the period 2008-2014 was 2987 (427 patients a year, corresponding to about 35 patients per 100,000 adult residents); the total number of admissions was 3453 (just over 490 a year). The direct healthcare costs incurred by the Marche region for episodes of diverticulitis in 2008-2014 amounted to approximately €11.4 million (€1.6 million a year), of which €10.9 million (95.5%) for the hospitalizations, € 246,000 (2.1%) for pharmaceutical treatment and €270,000 (2.4%) for specialist outpatient services. The average annual cost per patient was €3826, of which €3653 was for hospitalization, while pharmaceutical expenditure and specialist services accounted for €83 and €90, respectively. The cohort of patients undergoing a first admission for diverticulitis between 2010 and 2013 was made up of 1729 people (54.4% women, mean age 68.9 years), of whom 1500 (86.8%) did not undergo surgery while in hospital. Hospital mortality, recorded only for the over-65 age class, averaged 1.2%; for patients not receiving surgery during the initial hospitalization it was 0.5%, reaching 5.2% in patients undergoing surgery. The percentage of patients with one or more readmissions for diverticulitis within a year of the first was on average 7.8% and in 48% of cases this resulted in surgery. CONCLUSIONS: Our study is the first analysis in Italy to use real-world data to measure the financial impact of diverticular disease. Assuming that the diagnostic and therapeutic behaviour identified in the Marche region could be representative of the situation nationwide, the estimated annual number of hospitalizations in Italy for acute episodes of diverticulitis is 19,000. The total amount of economic resources needed to treat patients suffering from acute episodes of diverticulitis is estimated at €63.5 million a year

Prozeß-produzierte Daten in der Rechtssoziologie: Erfahrungen aus einer Untersuchung der Praxis des Insolvenzrechts

Die Tatsache, daß Entscheidungen und Prozesse im modernen Rechtssystem nur zu verstehen, zu erklären und zu kritisieren sind, wenn die "Welt der Akten" ausdrückliche Beachtung findet, ist bislang in der Rechtssoziologie nicht in ausreichender Weise berücksichtigt worden. Mit den konventionellen Beobachtungs- und Befragungsmethoden kann die Rechtssoziologie ihrem Gegenstand nicht gerecht werden. Aktenanalyse soll diese Methoden zwar nicht ersetzen, muß sie aber notwendigerweise ergänzen. Akten, Dokumente oder andere Aufzeichnungen bieten nicht nur Informationen über Abläufe, sondern auch über die jeweilige Struktur des Verfahrens. Um die Bedeutung der großangelegten Aktenanalyse im Rechtssystem der Bundesrepublik zu exemplifizieren, stellen die Verf. ein Insolvenzprojekt vor, das 1975-1977 am Max-Planck-Institut für ausländisches und internationales Privatrecht durchgeführt worden ist. Die entsprechenden Konkursakten enthalten nicht nur die Kennziffern des Insolvenzverfahrens, sondern sie bieten zudem zahlreiche Informationen über die Rechtsstruktur insgesamt, ihre Stellung zu wirtschaftlichen Abläufen, zu sozialen Abläufen und zur gesellschaftlichen Organisation von Recht und Wirtschaft. Der Beitrag beschreibt im einzelnen das methodische Vorgehen (schriftliche Befragungen und Aktenanalysen), wobei insbesondere die Probleme bei der Datenerhebung aus Akten präsentiert werden (Erstellen der Auswertungsbögen, Zugangsprobleme, Qualität der Daten, Verarbeitung der Daten). Die Verf. weisen abschließend nochmals auf die Bedeutung prozeß-produzierter Daten hin, auf deren Berücksichtigung und systematische Analyse gerade die Rechtssoziologie nicht verzichten kann. (JL

N-d scattering above the deuteron breakup threshold

The complex Kohn variational principle and the (correlated) Hyperspherical Harmonics technique are applied to study the N--d scattering above the deuteron breakup threshold. The configuration with three outgoing nucleons is explicitly taken into account by solving a set of differential equations with outgoing boundary conditions. A convenient procedure is used to obtain the correct boundary conditions at values of the hyperradius $\approx 100$ fm. The inclusion of the Coulomb potential is straightforward and does not give additional difficulties. Numerical results have been obtained for a simple s-wave central potential. They are in nice agreement with the benchmarks produced by different groups using the Faddeev technique. Comparisons are also done with experimental elastic N--d cross section at several energies.Comment: LaTeX, 13 pages, 3 figure

EBF recommendation on practical management of critical reagents for antidrug antibody ligand-binding assays

Immunogenicity assays are required to measure antidrug antibodies that are generated against biotherapeutic modalities. As for any ligand-binding assays, critical reagents (CR) play a crucial role in immunogenicity assays, as the robustness and reliability of an assay are defined by the quality and long-term availability of these reagents. The current regulatory guidelines do not provide clear directions on how to implement and verify lot-to-lot changes of CR during an assay life cycle, or the acceptance criteria that should be used when implementing new lots of CR. These aspects were extensively discussed within the European Bioanalysis Forum community. In this paper, CR for immunogenicity assays are identified and the minimum requirements for introducing new lots of CR in immunogenicity assays are described

A retrospective analysis of prescription medications as it correlates to falls for older adults

Objectives: To determine the correlation between falls and two medication factors: the class of medications and potentially inappropriate medications (PIMs) prescribed to community-dwelling older adults aged 55 and older. Methods: Retrospective, cross-sectional study. Home health patients residing in a Texas/Mexico border community and reporting at least one fall within the past month. Medication use, medication classification, and potentially inappropriate medications (PIM) recorded by level of falls; non-fallers and recurrent fallers. Results: Of 99 participants, 13.1% reported falling once and 86.9% reported two or more falls. Participant’s average number of medications used was 10.51 (SD 5.75) with 93.9% having four or more prescribed medications. Average number of PIMs prescribed per participant was 1.42 (SD 1.51) with at least one PIM prescribed to 65.6% of participants. Twenty three out of 83 identified classes of prescribed medications met criteria for the study’s analyses but resulted in no significant association to falls when comparing NF to RF. Agents acting on the renin-angiotensin system and lipid modifying agents were the most frequently prescribed medication classes (N=55, 55.6%). Ibuprofen was the PIM most frequently prescribed (n=13, 13.1%). The correlation between use of a prescribed PIM and number of falls was not statistically significant (p=0.128). Conclusions: There was no correlation between classes of medication and level of falls. Recurrent fallers were more likely to have been prescribed a PIM than non-fallers (not significant). Although the analyses conducted for this study did not result in statistical significance, the high prevalence of polypharmacy and prescribed PIMs observed in these participants warrants a thorough review of medications to reduce fall risks among older adults