Charles M. Breder, Jr.: Hypothetical considerations, 1931-1937

Charles M. Breder Jr. “hypothesis” diary is a deviation from the field diaries that form part of the Breder collection housed at the Arthur Vining Davis Library, Mote Marine Laboratory. There are no notes or observations from specific scientific expeditions in the document. Instead, the contents provide an insight into the early meticulous scientific thoughts of this biologist, and how he examines and develops these ideas. It is apparent that among Dr. Breder’s passions was his continual search for knowledge about questions that still besieged many scientists. Topics discussed include symmetry, origin of the atmosphere, origin of life, mechanical analogies of organisms, aquaria as an organism, astrobiology, entropy, evolution of species, and other topics. The diary was transcribed as part of the Coastal Estuarine Data/Document Rescue and Archeology effort for South Florida. (PDF contains 33 pages

Repeated Reading: Using Audiotaped Books and Activities to Help At-Risk Readers

The purpose of this project was to determine whether repeated reading with an audio model would significantly supplement the literacy instruction of atrisk readers. Research related to reading practice, the relationship between fluency and reading development, and repeated reading was read, evaluated, and summarized. A positive relationship between repeated reading and reading growth (i.e., fluency and comprehension) was indicated from this review. The literature review provided a rational and guidelines for using repeated reading with at-risk readers. A manual containing a teacher\u27s guide on repeated reading with an audio model and related literacy activities was created

Letter from Arthur Stover, also letters of recommendation from S. Fortier and Elwood Mead

Letter concerning a position in the engineering department at Utah Agricultural College, as well as recommendations

Are Drug Companies Living Up to Their Human Rights Responsibilities? The Merck Perspective

As one viewpoint of three in the PLoS Medicine Debate on whether drug companies are living up to their human rights responsibilities, Geralyn Ritter, Vice President of Global Health Policy and Corporate Social Responsibility at Merck & Co., argues that that multiple stakeholders could do more to help States deliver the right to health

Mthfs is an Essential Gene in Mice and a Component of the Purinosome

Tetrahydrofolates (THF) are a family of cofactors that function as one-carbon donors in folate-dependent one-carbon metabolism, a metabolic network required for the de novo synthesis of purines, thymidylate, and for the remethylation of homocysteine to methionine in the cytoplasm. 5-FormylTHF is not a cofactor in one-carbon metabolism, but serves as a storage form of THF cofactors. 5-formylTHF is mobilized back into the THF cofactor pool by methenyltetrahydrofolate synthetase (MTHFS), which catalyzes the irreversible and ATP-dependent conversion 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate. Mthfs is not an essential gene in Arabidopsis, but MTHFS expression is elevated in animal tumors, enhances de novo purine synthesis, confers partial resistance to antifolate purine synthesis inhibitors and increases rates of folate catabolism in mammalian cell cultures. However, the mechanisms underlying these effects of MTHFS expression have yet to be established. The purpose of this study was to investigate the role and essentiality of MTHFS in mice. Mthfs was disrupted through the insertion of a gene trap vector between exons 1 and 2. Mthfsgt/+ mice were fertile and viable. No Mthfsgt/gt embryos were recovered from Mthfsgt/+ intercrosses, indicating Mthfs is an essential gene in mice. Tissue MTHFS protein levels are decreased in both Mthfsgt/+ and Mthfs+/+ mice placed on a folate and choline deficient diet, and mouse embryonic fibroblasts from Mthfsgt/+ embryos exhibit decreased capacity for de novo purine synthesis without impairment in de novo thymidylate synthesis. MTHFS was shown to co-localize with two enzymes of the de novo purine synthesis pathway in HeLa cells in a cell cycle-dependent manner, and to be modified by the small ubiquitin-like modifier (SUMO) protein. Mutation of the consensus SUMO modification sites on MTHFS eliminated co-localization of MTHFS with the de novo purine biosynthesis pathway under purine-deficient conditions. The results from this study indicate that MTHFS enhances purine biosynthesis by delivering 10-formylTHF to the purinosome in a SUMO-dependent fashion

You Have a Tutorial, Now What?: An Analysis of Factors Contributing to an Expanded Use of Online Research Tutorials by Academic Librarians

This study seeks to better understand how online tutorials are being incorporated into instruction efforts at academic libraries. University of North Carolina at Chapel Hill librarians and the tutorials they created are grouped by the degree to which the librarians are reliant on the tutorials for in-class instruction, referred to here as expanded use. The results of this research identified the following factors that may play a role in determining the level of expanded use of a tutorial: the relationship between the intended audience of the tutorial to the actual audience in the classroom, the relationship between the needs filled by the tutorial and the actual needs of the patrons, the degree to which visual elements are incorporated into the tutorial, the degree to which tutorials are recognized as marketing tools, the involvement of faculty in promoting tutorials, and the level of demand for library instruction