The Government Contractor Defense

Litigation involving defective products has increasingly become a pre-trial battle to overcome a series of technical defenses that have become a stock part of the manufacturer\u27s defense. Defendants invariably raise the government contractor defense where the defective product resulted from some governmental involvement in the manufacturing process, no matter how peripheral or superfluous was the government\u27s involvement in that process. The defense by its nature only applies to design defect cases. A defect in the manufacturing process is not protected by the defense

The Effects of Sex and Hormonal Implant on Carcass Characteristics and Palatability

Consumer demand for beef has undergone a number of dramatic changes during recent years. Consumers are expressing a preference for reasonably priced beef cuts with a high proportion of lean in relation to fat. Increasing demand for ground beef and steaks has prompted the meat industry to look at the use of a variety of production methods. The hotel, retail and industrial trades utilize large amounts of ground beef and restructured steaks. Future production may be geared toward making ground beef from chuck, foreshank, brisket, short plate, flank and round, with the desire to sell the rib meat and short loin as steaks in order to lower the break-even price of the ground beef. Consumers will ultimately determine the type of beef produced in the future. Increasing interests in uncastrated males is related to the declining demand for animal fat, the increased emphasis on more efficient red meat production and the needs of a changing world population. Although beef from bullocks is not being marketed on a large scale in the United States today present trends indicate that “choice” bullock beef may be economically feasible in the future. Carcasses and wholesale cuts which meet the quality standards desired are of greatest value. The value of wholesale cuts as predictors of total beef carcass merit is essential in developing a more desirable consumer product. Comparative relationships between wholesale cuts and total beef carcass composition provide a means of examining different management practices. This study was undertaken to provide evidence on the comparative carcass characteristics of animals from similar genetic and production environments by the use of rib sections obtained from the carcasses. Some effects of castration and hormonal injections on the quality and palatability of fir steaks were observed

You\u27ve Got It Coming -- Winning Discovery through Effective Motions Practice

An effective discovery motion begins with the underlying discovery document and a thoughtful plan for discovery. This article will begin with a brief overview of the more important substantive legal points relevant to discovery. The materials will then address some of the more recurrent problems encountered by counsel during the course of discovery. Finally, the discussion will examine the timing, form and content of discovery motions

Pharmacologic inhibition of RGD-binding integrins ameliorates fibrosis and improves function following kidney injury

Fibrosis is a final common pathway for many causes of progressive chronic kidney disease (CKD). Arginine-glycine-aspartic acid (RGD)-binding integrins are important mediators of the pro-fibrotic response by activating latent TGF-β at sites of injury and by providing myofibroblasts information about the composition and stiffness of the extracellular matrix. Therefore, blockade of RGD-binding integrins may have therapeutic potential for CKD. To test this idea, we used small-molecule peptidomimetics that potently inhibit a subset of RGD-binding integrins in a murine model of kidney fibrosis. Acute kidney injury leading to fibrosis was induced by administration of aristolochic acid. Continuous subcutaneous administration of CWHM-12, an RGD integrin antagonist, for 28 days improved kidney function as measured by serum creatinine. CWHM-12 significantly reduced Collagen 1 (Col1a1) mRNA expression and scar collagen deposition in the kidney. Protein and gene expression markers of activated myofibroblasts, a major source of extracellular matrix deposition in kidney fibrosis, were diminished by treatment. RNA sequencing revealed that inhibition of RGD integrins influenced multiple pathways that determine the outcome of the response to injury and of repair processes. A second RGD integrin antagonist, CWHM-680, administered once daily by oral gavage was also effective in ameliorating fibrosis. We conclude that targeting RGD integrins with such small-molecule antagonists is a promising therapeutic approach in fibrotic kidney disease

An Inventory of the Goods and Chattels Rights and Credits of John McCery of Amwell

Inventory of all the things that belonged to John McCery, which were appraised by John Hart and David Stout, 1767.https://digitalcommons.wofford.edu/littlejohnmss/1073/thumbnail.jp

Improving capital budgeting decisions with real options

In this article we provide accounting practitioners with a primer on how to supplement traditional discounted cash flow (DCF) analysis with real options. We use an example of a rental car company that is considering the purchase of a new car for its rental fleet. Management is trying to decide whether to buy a conventional gasoline-engine automobile or a hybrid vehicle. Within this decision context we illustrate the embedded options the company should consider given uncertainty of a new energy bill offering income-tax credits for the purchase of commercially operated hybrid vehicles. Our step-by-step approach shows how to incorporate these real options formally into the capital budgeting process