In the eye of Apollo: world literature from Goethe to Google

“National literature is now a rather unmeaning term; the epoch of world literature is at hand, and everyone must strive to hasten its approach.” Thus the Olympian poet Goethe spoke to his young disciple Johann Peter Eckermann in Weimar in 1827. In Copenhagen, 1899, the great European critic Georg Brandes revived the term as a response to the surge of nationalism in European literature and culture; and in 1952, the emigrant critic, Erich Auerbach, turned to Goethe’s enduring concept as a framework for the emerging future of philology and humanism after WWII. Recent years have witnessed yet another revival of interest in world literature fuelled by a growing concern with a globalized marketplace, migration and new modes of communication. Goethe’s conversations with Eckermann, from which the concept was popularized, inaugurated a dialogue, based on a new cultural awareness of a global modernity, in which we still take part today. This seminar will introduce to the shifting meanings and applications of the concept of world literature, especially as it relates to changing conceptions of international and national cultures and literatures, in order to suggest productive perspectives on the conditions of literature in a transnational space of globalized cultures and media

Nordic noir in the UK: The allure of accessible difference

This article takes a closer look at the recent success of Nordic noir in the United Kingdom considering especially the ways in which this particular aesthetic or popular cultural form has come to function as a medium for intercultural communication wherein the perceived Nordicness of the genre plays a central role in negotiating social and cultural desires and challenges pertaining mostly to the receiving culture. Nordic noir, I argue, is not merely a fleeting fashion but a publishing and media phenomenon that tells us something about particular patterns of cultural consumption in the first decades of the twenty-first century United Kingdom

‘No absolute privacy’: Henry James and the Ethics of Reading Authors’ Letters

Authors’ private letters play a significant role in Henry James’s fiction, literary criticism and in his literary and authorial legacy. They are privileged discursive objects activating fundamental issues of privacy and publicity, canonicity and the material condition of literature. The letter is a contested discursive object in James’s work, since it is at one and the same time a potent figure for authenticity and interiority, and consequently poses a threat to the author’s desire to control his own literary corpus and his privacy. In this article, James’s personal and private investment in designing his literary testament (his private letters and his definitive collected edition) is discussed in the context of his ethical and aesthetic concerns with reading the publications of authors’ private correspondences

Høje tanker og tryksværte i romantikken: antologi reviderer vores syn på 1800-tallets digtning og bogmarked i Skandinavian og Storbritannien

A review of "Mellem ånd og tryksværte: Studier i trykkekulturen og den romantiske litteratur", Robert W. Rix (ed.), Museum Tusculanums Forlag, 2015, 201 pp

Nonribosomal peptides, key biocontrol components for Pseudomonas fluorescens In5, isolated from a Greenlandic suppressive soil.

UnlabelledPotatoes are cultivated in southwest Greenland without the use of pesticides and with limited crop rotation. Despite the fact that plant-pathogenic fungi are present, no severe-disease outbreaks have yet been observed. In this report, we document that a potato soil at Inneruulalik in southern Greenland is suppressive against Rhizoctonia solani Ag3 and uncover the suppressive antifungal mechanism of a highly potent biocontrol bacterium, Pseudomonas fluorescens In5, isolated from the suppressive potato soil. A combination of molecular genetics, genomics, and matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) imaging mass spectrometry (IMS) revealed an antifungal genomic island in P. fluorescens In5 encoding two nonribosomal peptides, nunamycin and nunapeptin, which are key components for the biocontrol activity by strain In5 in vitro and in soil microcosm experiments. Furthermore, complex microbial behaviors were highlighted. Whereas nunamycin was demonstrated to inhibit the mycelial growth of R. solani Ag3, but not that of Pythium aphanidermatum, nunapeptin instead inhibited P. aphanidermatum but not R. solani Ag3. Moreover, the synthesis of nunamycin by P. fluorescens In5 was inhibited in the presence of P. aphanidermatum. Further characterization of the two peptides revealed nunamycin to be a monochlorinated 9-amino-acid cyclic lipopeptide with similarity to members of the syringomycin group, whereas nunapeptin was a 22-amino-acid cyclic lipopeptide with similarity to corpeptin and syringopeptin.ImportanceCrop rotation and systematic pest management are used to only a limited extent in Greenlandic potato farming. Nonetheless, although plant-pathogenic fungi are present in the soil, the farmers do not experience major plant disease outbreaks. Here, we show that a Greenlandic potato soil is suppressive against Rhizoctonia solani, and we unravel the key biocontrol components for Pseudomonas fluorescens In5, one of the potent biocontrol bacteria isolated from this Greenlandic suppressive soil. Using a combination of molecular genetics, genomics, and microbial imaging mass spectrometry, we show that two cyclic lipopeptides, nunamycin and nunapeptin, are important for the biocontrol activity of P. fluorescens In5 both in vitro and in microcosm assays. Furthermore, we demonstrate that the synthesis of nunamycin is repressed by the oomycete Pythium aphanidermatum. Overall, our report provides important insight into interkingdom interference between bacteria and fungi/oomycetes

Interplay of flg22-induced defence responses and nodulation in Lotus japonicus

In this study the interplay between the symbiotic and defence signalling pathways in Lotus japonicus was investigated by comparing the responses to Mesorhizobium loti, the symbiotic partner of L. japonicus, and the elicitor flg22, a conserved peptide motif present in flagellar protein of a wide range of bacteria. It was found that defence and symbiotic pathways overlap in the interaction between L. japonicus and M. loti since similar responses were induced by the mutualistic bacteria and flg22. However, purified flagellin from M. loti did not induce any response in L. japonicus, which suggests the production of other elicitors by the symbiotic bacteria. Defence responses induced by flg22 caused inhibition of rhizobial infection and delay in nodule organogenesis, as demonstrated by the negative effect of flg22 in the formation of spontaneous nodules in the snf1 L. japonicus mutant, and the inhibition of NSP1 and NSP2 genes. This indicates the antagonistic effect of the defence pathway on the nodule formation in the initial rhizobium-legume interaction. However, the fact that flg22 did not affect the formation of new nodules once the symbiosis was established indicates that after the colonization of the host plant by the symbiotic partner, the symbiotic pathway has prevalence over the defensive response. This result is also supported by the down-regulation of the expression levels of the flg22 receptor FLS2 in the nodular tissu

Discovery of novel enzymes with industrial potential from a cold and alkaline environment by a combination of functional metagenomics and culturing

BACKGROUND: The use of cold-active enzymes has many advantages, including reduced energy consumption and easy inactivation. The ikaite columns of SW Greenland are permanently cold (4-6°C) and alkaline (above pH 10), and the microorganisms living there and their enzymes are adapted to these conditions. Since only a small fraction of the total microbial diversity can be cultured in the laboratory, a combined approach involving functional screening of a strain collection and a metagenomic library was undertaken for discovery of novel enzymes from the ikaite columns. RESULTS: A strain collection with 322 cultured isolates was screened for enzymatic activities identifying a large number of enzyme producers, with a high re-discovery rate to previously characterized strains. A functional expression library established in Escherichia coli identified a number of novel cold-active enzymes. Both α-amylases and β-galactosidases were characterized in more detail with respect to temperature and pH profiles and one of the β-galactosidases, BGal(I17E2), was able to hydrolyze lactose at 5°C. A metagenome sequence of the expression library indicated that the majority of enzymatic activities were not detected by functional expression. Phylogenetic analysis showed that different bacterial communities were targeted with the culture dependent and independent approaches and revealed the bias of multiple displacement amplification (MDA) of DNA isolated from complex microbial communities. CONCLUSIONS: Many cold- and/or alkaline-active enzymes of industrial relevance were identified in the culture based approach and the majority of the enzyme-producing isolates were closely related to previously characterized strains. The function-based metagenomic approach, on the other hand, identified several enzymes (β-galactosidases, α-amylases and a phosphatase) with low homology to known sequences that were easily expressed in the production host E. coli. The β-galactosidase BGal(I17E2) was able to hydrolyze lactose at low temperature, suggesting a possibly use in the dairy industry for this enzyme. The two different approaches complemented each other by targeting different microbial communities, highlighting the usefulness of combining methods for bioprospecting. Finally, we document here that ikaite columns constitute an important source of cold- and/or alkaline-active enzymes with industrial application potential