396 research outputs found
Non-equilibrium steady state of sparse systems
A resistor-network picture of transitions is appropriate for the study of
energy absorption by weakly chaotic or weakly interacting driven systems. Such
"sparse" systems reach a novel non-equilibrium steady state (NESS) once coupled
to a bath. In the stochastic case there is an analogy to the physics of
percolating glassy systems, and an extension of the fluctuation-dissipation
phenomenology is proposed. In the mesoscopic case the quantum NESS might differ
enormously from the stochastic NESS, with saturation temperature determined by
the sparsity. A toy model where the sparsity of the system is modeled using a
log-normal random ensemble is analyzed.Comment: 6 pages, 6 figures, EPL accepted versio
Resistive Switching Assisted by Noise
We extend results by Stotland and Di Ventra on the phenomenon of resistive
switching aided by noise. We further the analysis of the mechanism underlying
the beneficial role of noise and study the EPIR (Electrical Pulse Induced
Resistance) ratio dependence with noise power. In the case of internal noise we
find an optimal range where the EPIR ratio is both maximized and independent of
the preceding resistive state. However, when external noise is considered no
beneficial effect is observed.Comment: To be published in "Theory and Applications of Nonlinear Dynamics:
Model and Design of Complex Systems", Proceedings of ICAND 2012 (Springer,
2013
Quantum response of weakly chaotic systems
Chaotic systems, that have a small Lyapunov exponent, do not obey the common
random matrix theory predictions within a wide "weak quantum chaos" regime.
This leads to a novel prediction for the rate of heating for cold atoms in
optical billiards with vibrating walls. The Hamiltonian matrix of the driven
system does not look like one from a Gaussian ensemble, but rather it is very
sparse. This sparsity can be characterized by parameters and that
reflect the percentage of large elements, and their connectivity respectively.
For we use a resistor network calculation that has direct relation to the
semi-linear response characteristics of the system.Comment: 7 pages, 5 figures, expanded improved versio
Energy absorption by "sparse" systems: beyond linear response theory
The analysis of the response to driving in the case of weakly chaotic or
weakly interacting systems should go beyond linear response theory. Due to the
"sparsity" of the perturbation matrix, a resistor network picture of
transitions between energy levels is essential. The Kubo formula is modified,
replacing the "algebraic" average over the squared matrix elements by a
"resistor network" average. Consequently the response becomes semi-linear
rather than linear. Some novel results have been obtained in the context of two
prototype problems: the heating rate of particles in Billiards with vibrating
walls; and the Ohmic Joule conductance of mesoscopic rings driven by
electromotive force. Respectively, the obtained results are contrasted with the
"Wall formula" and the "Drude formula".Comment: 8 pages, 7 figures, short pedagogical review. Proceedings of FQMT
conference (Prague, 2011). Ref correcte
Diffractive energy spreading and its semiclassical limit
We consider driven systems where the driving induces jumps in energy space:
(1) particles pulsed by a step potential; (2) particles in a box with a moving
wall; (3) particles in a ring driven by an electro-motive-force. In all these
cases the route towards quantum-classical correspondence is highly non-trivial.
Some insight is gained by observing that the dynamics in energy space, where
is the level index, is essentially the same as that of Bloch electrons in a
tight binding model, where is the site index. The mean level spacing is
like a constant electric field and the driving induces long range hopping
1/(n-m).Comment: 19 pages, 11 figs, published version with some improved figure
Quantum anomalies and linear response theory
The analysis of diffusive energy spreading in quantized chaotic driven
systems, leads to a universal paradigm for the emergence of a quantum anomaly.
In the classical approximation a driven chaotic system exhibits stochastic-like
diffusion in energy space with a coefficient that is proportional to the
intensity of the driving. In the corresponding quantized problem
the coherent transitions are characterized by a generalized Wigner time
, and a self-generated (intrinsic) dephasing process leads to
non-linear dependence of on .Comment: 8 pages, 2 figures, textual improvements (as in published version
Resistance of the target islet tissue to autoimmune destruction contributes to genetic susceptibility in Type 1 diabetes
Type 1 diabetes occurs when self-reactive T lymphocytes destroy the insulin-producing islet β cells of the pancreas. The defects causing this disease have often been assumed to occur exclusively in the immune system. We present evidence that genetic variation at the Idd9 diabetes susceptibility locus determines the resilience of the targets of autoimmunity, the islets, to destruction. Susceptible islets exhibit hyper-responsiveness to inflammatory cytokines resulting in enhanced cell death and increased expression of the death receptor Fas. Fas upregulation in β cells is mediated by TNFR2, and colocalization of TNFR2 with the adaptor TRAF2 in NOD β cells is altered. TNFR2 lies within the candidate Idd9 interval and the diabetes-associated variant contains a mutation adjacent to the TRAF2 binding site. A component of diabetes susceptibility may therefore be determined by the target of the autoimmune response, and protective TNFR2 signaling in islets inhibit early cytokine-induced damage required for the development of destructive autoimmunity. This article was reviewed by Matthiasvon Herrath, HaraldVon Boehmer, and Ciriaco Piccirillo (nominated by Ethan Shevach)
Derivation of the Rules of Quantum Mechanics from Information-Theoretic Axioms
Conventional quantum mechanics with a complex Hilbert space and the Born Rule
is derived from five axioms describing properties of probability distributions
for the outcome of measurements. Axioms I,II,III are common to quantum
mechanics and hidden variable theories. Axiom IV recognizes a phenomenon, first
noted by Turing and von Neumann, in which the increase in entropy resulting
from a measurement is reduced by a suitable intermediate measurement. This is
shown to be impossible for local hidden variable theories. Axiom IV, together
with the first three, almost suffice to deduce the conventional rules but allow
some exotic, alternatives such as real or quaternionic quantum mechanics. Axiom
V recognizes a property of the distribution of outcomes of random measurements
on qubits which holds only in the complex Hilbert space model. It is then shown
that the five axioms also imply the conventional rules for all dimensions.Comment: 20 pages, 6 figure
Evaluation of Sustained Virologic Response as a Relevant Surrogate Endpoint for Long-term Outcomes of Hepatitis C Virus Infection
Evolution of TNF-Induced Apoptosis Reveals 550 My of Functional Conservation
The Precambrian explosion led to the rapid appearance of most major animal phyla alive today. It has been argued that the complexity of life has steadily increased since that event. Here we challenge this hypothesis through the characterization of apoptosis in reef-building corals, representatives of some of the earliest animals. Bioinformatic analysis reveals that all of the major components of the death receptor pathway are present in coral with high-predicted structural conservation with Homo sapiens. The TNF receptor-ligand superfamilies (TNFRSF/TNFSF) are central mediators of the death receptor pathway, and the predicted proteome of Acropora digitifera contains more putative coral TNFRSF members than any organism described thus far, including humans. This high abundance of TNFRSF members, as well as the predicted structural conservation of other death receptor signaling proteins, led us to wonder what would happen if corals were exposed to a member of the human TNFSF (HuTNFα). HuTNFα was found to bind directly to coral cells, increase caspase activity, cause apoptotic blebbing and cell death, and finally induce coral bleaching. Next, immortalized human T cells (Jurkats) expressing a functional death receptor pathway (WT) and a corresponding Fas-associated death domain protein (FADD) KO cell line were exposed to a coral TNFSF member (AdTNF1) identified and purified here. AdTNF1 treatment resulted in significantly higher cell death (P \u3c 0.0001) in WT Jurkats compared with the corresponding FADD KO, demonstrating that coral AdTNF1 activates the H. sapiens death receptor pathway. Taken together, these data show remarkable conservation of the TNF-induced apoptotic response representing 550 My of functional conservation
- …