Nonlinear localized modes in two-dimensional electrical lattices

We report the observation of spontaneous localization of energy in two spatial dimensions in the context of nonlinear electrical lattices. Both stationary and traveling self-localized modes were generated experimentally and theoretically in a family of two-dimensional square, as well as hon- eycomb lattices composed of 6x6 elements. Specifically, we find regions in driver voltage and frequency where stationary discrete breathers, also known as intrinsic localized modes (ILM), exist and are stable due to the interplay of damping and spatially homogeneous driving. By introduc- ing additional capacitors into the unit cell, these lattices can controllably induce traveling discrete breathers. When more than one such ILMs are experimentally generated in the lattice, the interplay of nonlinearity, discreteness and wave interactions generate a complex dynamics wherein the ILMs attempt to maintain a minimum distance between one another. Numerical simulations show good agreement with experimental results, and confirm that these phenomena qualitatively carry over to larger lattice sizes.Comment: 5 pages, 6 figure

Berries as a case study for crop wild relative conservation, use, and public engagement in Canada

Conservation of plant biodiversity, in particular crop wild relatives including those tended and cultivated by Indigenous Peoples, is critical to food security and agricul ture. Building on the 2019 road map for crop wild relatives, we examine berries as a case study for crop wild relative conservation, use, and public engagement. We focus on berries due not only to their economic, cultural, and nutritional importance but also because they are consumed fresh, providing a unique opportunity for individuals and communities to connect with plants. We outline health benefits, geographic dis tribution, and species at risk for Canadian berries. We describe practices, strategies, and approaches used by Indigenous Peoples to steward berries and emphasize the importance of traditional knowledge. We highlight opportunities for in situ and ex situ berry conservation and use of berries in plant breeding and Indigenous foodways. Our aim is to lay the groundwork for future collaborative efforts in these areas and to showcase berries as a useful case study for conservation of food plant biodiversity and public engagement

Inflammatory mediators in breast cancer: Coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition

<p>Abstract</p> <p>Background</p> <p>The inflammatory chemokines CCL2 (MCP-1) & CCL5 (RANTES) and the inflammatory cytokines TNFα & IL-1β were shown to contribute to breast cancer development and metastasis. In this study, we wished to determine whether there are associations between these factors along stages of breast cancer progression, and to identify the possible implications of these factors to disease course.</p> <p>Methods</p> <p>The expression of CCL2, CCL5, TNFα and IL-1β was determined by immunohistochemistry in patients diagnosed with: (1) Benign breast disorders (=healthy individuals); (2) Ductal Carcinoma <it>In Situ </it>(DCIS); (3) Invasive Ducal Carcinoma without relapse (IDC-no-relapse); (4) IDC-with-relapse. Based on the results obtained, breast tumor cells were stimulated by the inflammatory cytokines, and epithelial-to-mesenchymal transition (EMT) was determined by flow cytometry, confocal analyses and adhesion, migration and invasion experiments.</p> <p>Results</p> <p>CCL2, CCL5, TNFα and IL-1β were expressed at very low incidence in normal breast epithelial cells, but their incidence was significantly elevated in tumor cells of the three groups of cancer patients. Significant associations were found between CCL2 & CCL5 and TNFα & IL-1β in the tumor cells in DCIS and IDC-no-relapse patients. In the IDC-with-relapse group, the expression of CCL2 & CCL5 was accompanied by further elevated incidence of TNFα & IL-1β expression. These results suggest progression-related roles for TNFα and IL-1β in breast cancer, as indeed indicated by the following: (1) Tumors of the IDC-with-relapse group had significantly higher persistence of TNFα and IL-1β compared to tumors of DCIS or IDC-no-relapse; (2) Continuous stimulation of the tumor cells by TNFα (and to some extent IL-1β) has led to EMT in the tumor cells; (3) Combined analyses with relevant clinical parameters suggested that IL-1β acts jointly with other pro-malignancy factors to promote disease relapse.</p> <p>Conclusions</p> <p>Our findings suggest that the coordinated expression of CCL2 & CCL5 and TNFα & IL-1β may be important for disease course, and that TNFα & IL-1β may promote disease relapse. Further <it>in vitro </it>and <it>in vivo </it>studies are needed for determination of the joint powers of the four factors in breast cancer, as well as analyses of their combined targeting in breast cancer.</p

Aligning to the UN Sustainable Development Goals: Assessing Contributions of UBC Botanical Garden

The United Nations 2030 Agenda for Sustainable Development outlines 17 goals for the wellbeing of people and the planet. The purpose of this study was to understand how University of British Columbia Botanical Garden (UBCBG) contributes to the United Nations Sustainable Development Goals (UN-SDGs) and to identify opportunities for future action. To address this, we worked across departments to assess our programs and activities against the UN-SDG 17 goals and 169 targets. The UN-SDG indicators were only used to identify potential metrics that could be consider for future tracking. The main activities of UBCBG include ex situ plant conservation, sustainability education and community engagement. Our results found that UBCBG contributes to 12 of the 17 goals and 24 of the 169 targets. The two UN-SDGs with more targets aligned to UBCBG’s activities were Goal 15—Life on Land and Goal 12—Responsible Consumption and Production. Through its partnerships with other botanical gardens, research institutions and the regional government, the Garden amplifies its work at a global, national and regional level. We are re-imagining the role of botanical gardens in an age of equity, decolonization, the biodiversity crisis and the climate emergency. Since the UN-SDGs address both nature and people, they are an appropriate framework to guide our work.Science, Faculty ofBotany, Department ofReviewedFacult