Study on Investment in Agricultural Research: Review for Switzerland

This report forms part of the deliverables from a project called "IMPRESA" which has been awarded financial support by the European Commission under the 7th Framework Programme. The project aims to evaluate the impact of research on agriculture performed in the EU, collecting data on recent trends in investment in agricultural research, and developing a framework combining case studies, econometric analysis and modelling for assessing its impact. A first task is to prepare country-level analysis of the agricultural research expenditures and an assessment of the availabilities of data regarding public and private investments in agricultural research. Agricultural research covers all research on the promotion of agriculture, forestry, fisheries and foodstuff production. It includes: research on chemical fertilisers, biocides, biological pest control and the mechanisation of agriculture; research on the impact of agricultural and forestry activities on the environment; research in the field of developing food productivity and technology

Bottom-up feedback to improve clinical teaching: validation of the Swiss System for Evaluation of Teaching Qualities (SwissSETQ).

AIMS OF THE STUDY Clinical teaching is essential in preparing trainees for independent practice. To improve teaching quality, clinical teachers should be provided with meaningful and reliable feedback from trainees (bottom-up feedback) based on up-to-date educational concepts. For this purpose, we designed a web-based instrument, "Swiss System for Evaluation of Teaching Qualities" (SwissSETQ), building on a well-established tool (SETQsmart) and expanding it with current graduate medical education concepts. This study aimed to validate the new instrument in the field of anaesthesiology training. METHODS Based on SETQsmart, we developed an online instrument (primarily including 34 items) with generic items to be used in all clinical disciplines. We integrated the recent educational frameworks of CanMEDS 2015 (Canadian Medical Educational Directives for Specialists), and of entrustable professional activities (EPAs). Newly included themes were "Interprofessionalism", "Patient centredness", "Patient safety", "Continuous professional development', and "Entrustment decisions". We ensured content validity by iterative discussion rounds between medical education specialists and clinical supervisors. Two think-aloud rounds with residents investigated the response process. Subsequently, the instrument was pilot-tested in the anaesthesia departments of four major teaching hospitals in Switzerland, involving 220 trainees and 120 faculty. We assessed the instrument's internal structure (to determine the factorial composition) using exploratory factor analysis, internal statistical consistency (by Cronbach's alpha as an estimate of reliability, regarding alpha >0.7 as acceptable, >0.8 as good, >0.9 as excellent), and inter-rater reliability (using generalisability theory in order to assess the minimum number of ratings necessary for a valid feedback to one single supervisor). RESULTS Based on 185 complete ratings for 101 faculty, exploratory factor analysis revealed four factors explaining 72.3% of the variance (individual instruction 33.8%, evaluation of trainee performance 20.9%, teaching professionalism 12.8%; entrustment decisions 4.7%). Cronbach's alpha for the total score was 0.964. After factor analysis, we removed one item to arrive at 33 items for the final instrument. Generalisability studies yielded a minimum of five to six individual ratings to provide reliable feedback to one supervisor. DISCUSSION The SwissSETQ possesses high content validity and an "excellent" internal structure for integrating up-to-date graduate medical education concepts. Thereby, the tool allows reliable bottom-up feedback by trainees to support clinical teachers in improving their teaching. Transfer to disciplines other than anaesthesiology needs to be further explored

Capability of low-temperature SQUID for transient electromagnetics under anthropogenic noise conditions

Transient electromagnetics (TEM) is a well-established method for mineral, groundwater, and geothermal exploration. Superconducting quantum interference device (SQUID)-based magnetic-field receivers used for TEM have quantitative advantages and higher sensitivity compared with commonly used induction coils. Special applications are deep soundings with target depths > 1 km and settings with conductive overburden. However, SQUIDs have rarely been applied for TEM measurements in environments with significant anthropogenic noise. We compared a low-temperature SQUID with a commercially available induction coil in an area affected by anthropogenic noise. We acquired four fixed-loop data sets with totally 61 receiver stations close to Bad Frankenhausen, Germany. The high sensitivity of the SQUID enables low noise levels, which lead to longer high-quality transient data compared with the induction coil. The effect of anthropogenic and natural noise sources is more critical for the coil than for the SQUID data. In the vicinity of the transmitter loop, systematic distortion of the coil signals occurs at early times, most probably caused by sferic interferences. We have developed 1D inversion results of both receivers that matched well in general. However, the SQUID-based models were more consistent and showed greater depths of investigation. This led to a superior resolution of deeper layers and even enabled a potential detection of thin conducting targets at up to a 500 m depth. Moreover, we find that the SQUID data inversion revealed multidimensional effects within the conductive overburden. In this regard, we applied forward modeling to analyze systematic differences between inversion results of SQUID and coil data. We determine that low-temperature SQUIDs have the potential to significantly improve the reliability of subsurface models in suburban environments. Nevertheless, we recommend combined application of both types of receivers

Multiplex bacterial PCR in the bronchoalveolar lavage fluid of non-intubated patients with suspected pulmonary infection: a quasi-experimental study

Background Early pathogen identification in pulmonary infection is crucial to guide antibacterial therapy and decrease length of hospital stay. We hypothesise that compared to conventional diagnostic methods, a multiplex bacterial polymerase chain reaction assay has a higher diagnostic yield in bronchoalveolar lavage (BAL) fluid and improved clinical outcomes in patients with suspicion of pulmonary infection. Methods A prospective, monocentric, quasi-experimental, observational study was carried out. Unselected patients with suspected pulmonary infection who underwent bronchoscopy with BAL were included in the study over a period of 1 year. In addition to conventional diagnostic methods, a multiplex PCR bacterial assay was performed in BAL on a 2 week on: 1 week off pre-determined schedule. No therapeutic recommendations were provided to the treating physician. Results 605 cases were included, 54% of whom were immunosuppressed. Conventional diagnostic methods detected 56% of the bacteria evidenced by PCR. PCR failed to detect bacteria in 4% of the cases with a positive conventional diagnostic result. After bronchoscopy, 42% of the patients received antibacterial therapy for pulmonary infection for a median of 12 antibiotic days. There was no statistically significant difference in length of hospital stay (median 8 versus 8; p=0.839), antibiotic exposure (median 11 versus 14; p=0.362) or number of antibiotics prescribed (median 2 versus 2; p=0.595) between the two groups. Conclusions A multiplex bacterial PCR detected more bacteria in BAL fluid than conventional diagnostic methods. However, without a specific antibiotic stewardship approach and a clear understanding of the clinical implications of a positive or negative PCR result, the PCR results did not influence clinical outcomes

14C AMS measurement of gas diluted reactor graphite using a Gas Injection System

For the final disposal of reactor graphite a quantitative characterization of its radioactivity is needed. In this work an emphasis is placed on the isotope 14C, an isotope accessible to AMS measurements. Reactor graphite can be highly activated and therefore difficult to measure without the risk of contaminating the AMS setup. Using an Elemental Analyzer (EA), a Gas Injection System (GIS) and the 6 MV AMS system of the Institute for Nuclear Physics, University of Cologne, we automated the measurement process for gaseous, diluted samples. The presented work shows the first steps to verify the possibility of gas dilution and provides a comparison to samples with known concentrations of 14C. In the future, our system will provide a high sample throughput of gas-diluted probes with high activities

Ion beam techniques for nuclear waste management

An automated CO2 gas handling and injection system was developed. It is designed to dilute CO2 samples with blank gas in a mixing volume. The system is intended to be used for the characterization and quantification of 14C content in reactor graphite with accelerator mass spectrometry. A 100 kV accelerator system was developed to measure samples with high 14C content, to test the gas injection system and to measure the 3H content from gaseous releases of reactor graphite. Additionally, the Tandetron model 4130 was purchased from the Max-Planck Institute for Biogeochemistry Jena (Germany) and a concept was developed for installation at the accelerator building of the University of Cologne. With the new 3 MV system, new isotopic ratio measurements and ion beam techniques for material analysis can be performed. The system will be used for nuclear waste management measurements of isotopes, e.g. 3H, 14C, 36Cl, 41Ca and 55Fe, which are difficult to measure with other techniques