The impact of intermittent exposure to ambient temperature of 40 °C, at different development stages, on the blood picture of albino lab rat

In this paper, we investigated the effects of hyperthermic stress, involved in the intrauterine and early postnatal period, in the blood like the inner space, in fact in erythrocytes, hemoglobin, hematocrit and leucocytes. For this purpose we used albino laboratorial rat of the Wistar kind. The testing results led us to conclusion about the harmful influence of the hyperthermic stress in all of the investigated parameters, especially if it is applied in continuity. It’s manifested by increased number of erythrocytes and hematocrit value and change in the number of the leukocytes, which in state of hyperthermic stress, is reduced. Changes occur in relation between lymphocytes and neutrophilic leukocytes. Treatment in the intrauterine life has very small negative influence

Experimental Animal Models as a Fundamental Tool for the Development of New Radiopharmaceuticals

In this work, beside practical considerations including definition of the control groups, random assignment of animals to control/treatment groups, determination of the number of animals needed for each group and identification of the most appropriate statistical analysis, the effectiveness of animal models in providing biological information at the molecular level that can be actually translated to the human subject and the intrinsic limitations of this approach will be discussed by using different examples of experimental tracers