Interacting families of Calogero-type particles and SU(1,1) algebra

We study a one-dimensional model with F interacting families of Calogero-type particles. The model includes harmonic, two-body and three-body interactions. We emphasize the universal SU(1,1) structure of the model. We show how SU(1,1) generators for the whole system are composed of SU(1,1) generators of arbitrary subsystems. We find the exact eigenenergies corresponding to a class of the exact eigenstates of the F-family model. By imposing the conditions for the absence of the three-body interaction, we find certain relations between the coupling constants. Finally, we establish some relations of equivalence between two systems containing F families of Calogero-type particles.Comment: 16 pages, no figures, to be published in Mod.Phys.Lett.

Role of magnetic and orbital ordering at the metal-insulator transition in NdNiO3

Soft x-ray resonant scattering at the Ni L2,3 edges is used to test models of magnetic and orbital-ordering below the metal-insulator transition in NdNiO3. The large branching ratio of the L3 to L2 intensities of the (1/2,0,1/2) reflection and the observed azimuthal angle and polarization dependence originates from a non collinear magnetic structure. The absence of an orbital signal and the non collinear magnetic structure show that the nickelates are materials for which orbital ordering is absent at the metal-insulator transition.Comment: 10 pages, 4 figures, Physical Review B rapid communication, to be publishe

SAM68 is required for regulation of Pumilio by the NORAD long noncoding RNA

The number of known long noncoding RNA (lncRNA) functions is rapidly growing, but how those functions are encoded in their sequence and structure remains poorly understood. NORAD (noncoding RNA activated by DNA damage) is a recently characterized, abundant, and highly conserved lncRNA that is required for proper mitotic divisions in human cells. NORAD acts in the cytoplasm and antagonizes repressors from the Pumilio family that bind at least 17 sites spread through 12 repetitive units in NORAD sequence. Here we study conserved sequences in NORAD repeats, identify additional interacting partners, and characterize the interaction between NORAD and the RNA-binding protein SAM68 (KHDRBS1), which is required for NORAD function in antagonizing Pumilio. These interactions provide a paradigm for how repeated elements in a lncRNA facilitate function.</jats:p

Mehatronički sistemi traktora u funkciji savremene poljoprivredne proizvodnje

In past few decades significant changes happened in the field of technological development of agricultural tractors, leading to great improvements in different aspects of their operation. This is enabled, above all, by introducing of electronic control systems and their wide application in different systems of the tractor. Due to these changes, agricultural tractor has evolved from rough and robust heavy duty machine to high-tech system capable of executing fully new functions and achieving much higher level of overall working results. A several main examples can be named, such as greater energy efficiency, lower emission, greater quality of agro-technical operations, better soil protection and enhanced working conditions for human operator. New technologies, whose application has led to achieved results, are mostly based on mechatronic systems. This paper will give a basic overview of current achievements and discuss possibilities for future development, mainly focused on the tractor as mobile machine i.e. vehicle.U novije vreme došlo je do intenzivnih prodora u području tehnološkog razvoja poljoprivrednih traktora, što je dovelo do značajnih poboljšanja u svim aspektima njihove upotrebe. Dostignuti nivo razvoja u najvećoj meri omogućilo je uvođenje sistema elektronskog upravljanja i njihova široka primena na različitim sistemima traktora. Zahvaljujući ovim unapređenjima, traktor je od prvobitno relativno jednostavne i robusne mašine evoluirao u sofisticirani mobilni sistem visoke tehnologije sposoban za izvođenje potpuno novih funkcija i dostizanje znatno višeg nivoa sveukupnih rezultata rada. Ukratko se može navesti nekoliko najvažnijih primera, kao što su poboljšanje energetske efikasnosti, bolja zaštita zemljišta i okoline, povećanje produktivnosti i unapređenje kvaliteta agrotehničkih operacija, poboljšanje uslova rada rukovaoca itd. Nove tehnologije, čija primena je dovela do navedenih rezultata, pre svega su bazirane na mehatroničkim sistemima. U radu je, na osnovu istraživanja aktuelne literature, dat prikaz trenutnih dostignuća i pravaca istraživanja, i diskutovane mogućnosti daljeg razvoja. Zbog obimnosti tematike, rad je fokusiran prvenstveno na sam traktor kao mobilni sistem

Spectroscopy of orbital ordering in La0.5Sr1.5MnO4 : A many-body cluster calculation

We have studied the orbital ordering (OO) in La0.5Sr1.5MnO4 and its soft x-ray resonant diffraction spectroscopic signature at the Mn L2, L3 edges. We have modelled the system in second quantization as a small planar cluster consisting of a central Mn atom, with the first neighbouring shells of oxygen and Mn atoms. For the effective Hamiltonian we consider Slater-Koster parameters, charge transfer and electron correlation energies obtained from previous measurements on manganites. We calculate the OO as a function of oxygen distortion and spin correlation used as adjustable parameters. Their contribution as a function of temperature is clearly distinguished with a good spectroscopic agreement.Comment: 5 pages 3 figure

Alkylation damage causes MMR-dependent chromosomal instability in vertebrate embryos

SN1-type alkylating agents, like N-methyl-N-nitrosourea (MNU) and N-ethyl-N-nitrosourea (ENU), are potent mutagens. Exposure to alkylating agents gives rise to O6-alkylguanine, a modified base that is recognized by DNA mismatch repair (MMR) proteins but is not repairable, resulting in replication fork stalling and cell death. We used a somatic mutation detection assay to study the in vivo effects of alkylation damage on lethality and mutation frequency in developing zebrafish embryos. Consistent with the damage-sensing role of the MMR system, mutant embryos lacking the MMR enzyme MSH6 displayed lower lethality than wild-type embryos after exposure to ENU and MNU. In line with this, alkylation-induced somatic mutation frequencies were found to be higher in wild-type embryos than in the msh6 loss-of-function mutants. These mutations were found to be chromosomal aberrations that may be caused by chromosomal breaks that arise from stalled replication forks. As these chromosomal breaks arise at replication, they are not expected to be repaired by non-homologous end joining. Indeed, Ku70 loss-of-function mutants were found to be equally sensitive to ENU as wild-type embryos. Taken together, our results suggest that in vivo alkylation damage results in chromosomal instability and cell death due to aberrantly processed MMR-induced stalled replication forks

Residual γH2AX foci as an indication of lethal DNA lesions

<p>Abstract</p> <p>Background</p> <p>Evidence suggests that tumor cells exposed to some DNA damaging agents are more likely to die if they retain microscopically visible γH2AX foci that are known to mark sites of double-strand breaks. This appears to be true even after exposure to the alkylating agent MNNG that does not cause direct double-strand breaks but does produce γH2AX foci when damaged DNA undergoes replication.</p> <p>Methods</p> <p>To examine this predictive ability further, SiHa human cervical carcinoma cells were exposed to 8 DNA damaging drugs (camptothecin, cisplatin, doxorubicin, etoposide, hydrogen peroxide, MNNG, temozolomide, and tirapazamine) and the fraction of cells that retained γH2AX foci 24 hours after a 30 or 60 min treatment was compared with the fraction of cells that lost clonogenicity. To determine if cells with residual repair foci are the cells that die, SiHa cervical cancer cells were stably transfected with a RAD51-GFP construct and live cell analysis was used to follow the fate of irradiated cells with RAD51-GFP foci.</p> <p>Results</p> <p>For all drugs regardless of their mechanism of interaction with DNA, close to a 1:1 correlation was observed between clonogenic surviving fraction and the fraction of cells that retained γH2AX foci 24 hours after treatment. Initial studies established that the fraction of cells that retained RAD51 foci after irradiation was similar to the fraction of cells that retained γH2AX foci and subsequently lost clonogenicity. Tracking individual irradiated live cells confirmed that SiHa cells with RAD51-GFP foci 24 hours after irradiation were more likely to die.</p> <p>Conclusion</p> <p>Retention of DNA damage-induced γH2AX foci appears to be indicative of lethal DNA damage so that it may be possible to predict tumor cell killing by a wide variety of DNA damaging agents simply by scoring the fraction of cells that retain γH2AX foci.</p

Exclusion statistics,operator algebras and Fock space representations

We study exclusion statistics within the second quantized approach. We consider operator algebras with positive definite Fock space and restrict them in a such a way that certain state vectors in Fock space are forbidden ab initio.We describe three characteristic examples of such exclusion, namely exclusion on the base space which is characterized by states with specific constraint on quantum numbers belonging to base space M (e.g. Calogero-Sutherland type of exclusion statistics), exclusion in the single-oscillator Fock space, where some states in single oscillator Fock space are forbidden (e.g. the Gentile realization of exclusion statistics) and a combination of these two exclusions (e.g. Green's realization of para-Fermi statistics). For these types of exclusions we discuss extended Haldane statistics parameters g, recently introduced by two of us in Mod.Phys.Lett.A 11, 3081 (1996), and associated counting rules. Within these three types of exclusions in Fock space the original Haldane exclusion statistics cannot be realized.Comment: Latex,31 pages,no figures,to appear in J.Phys.A : Math.Ge