Amide-functionalized pillar[5]arenes as a novel class of macrocyclic receptors for the sensing of H<inf>2</inf>PO<inf>4</inf>^- anion

© The Royal Society of Chemistry 2016.A novel class of amide-functionalized pillar[5]arenes, that is, alkyl and aryl amide derivatives, has been synthesized. Highly selective binding of the dihydrogen phosphate anion over a range of anions by the new synthetic receptors is reported. First, the "binding strength-selectivity" relationship has been decided for the pillar[5]arene/anion systems

Supramolecular polymer based on aminated monosubstituted pillar[5]arene

© 2017, Pleiades Publishing, Ltd. The interaction of nonamethoxypillar[5]arene containing an ester fragment with a series of di- and triamines has yielded novel macrocyclic amide derivatives of pillar[5] arene. The data of NOESY 1 H– 1 H and DOSY NMR spectroscopy, dynamic light scattering, and transmission electron microscopy have revealed that nonamethoxypillar[5]arene containing diethylenediaminoamide moiety can form a network supramolecular polymer with average pores size of 100 nm

Pillar[5]arenes bearing amide and carboxylic groups as synthetic receptors for alkali metal ions

© ISUCT Publishing. Pillar[5]arenes bearing amide and carboxylic groups have demonstrated recognition performance for some representative alkali metal ions including Li + , Na + , K + and Cs + in series cations of s- and d-metals compared to pillar[5] arenes with hydroxyl, methoxy and acetone fragments. Their complexation abilities toward these cations were evaluated by UV–Vis technique. The complexation results revealed that pillar[5] arene, containing glicylglicyne groups, were the most efficient cation receptors for Li + , Na + , K + and Cs + over other synthesized and studied pillar[5]arenes. Introduction of long glycylglycide fragments into macrocycle structure allowed to increase the association constant logarithm in the case of Li + by 2 orders. In addition, in the set of macrocycles, incorporation of the additional amide fragments and carboxyl group into macrocycle structure leads to increasing the binding efficiency with alkali metal cations

Synthesis of p-tert-butylthiacalix[4]arene with spatially separated phosphoryl and amino groups

© 2017, Pleiades Publishing, Ltd. The reactions of p-tert-butylthiacalix[4]arenes containing phthalimide fragments with diethyl-[(p-toluenesulfonyl)oxymethyl)] phosphonate were used to synthesize new phosphonate derivatives in the 1,3-alternate configuration. Hydrolysis and hydrazinolysis of the products gave the corresponding amido- and aminophosphonate thiacalixarene derivatives. 1 H– 1 H NOESY NMR spectroscopy established a 1,3-alternate configuration of the synthesized macrocycles with spatially separated phosphoryl and amino groups

The Opportunity Process for Optimal Consumption and Investment with Power Utility

We study the utility maximization problem for power utility random fields in a semimartingale financial market, with and without intermediate consumption. The notion of an opportunity process is introduced as a reduced form of the value process of the resulting stochastic control problem. We show how the opportunity process describes the key objects: optimal strategy, value function, and dual problem. The results are applied to obtain monotonicity properties of the optimal consumption.Comment: 24 pages, forthcoming in 'Mathematics and Financial Economics

Electrochemical DNA Sensor Based on Carbon Black—Poly(methylene blue)—Poly(neutral red) Composite

The detection of small molecules interacting with DNA is important for the assessment of potential hazards related to the application of rather toxic antitumor drugs, and for distinguishing the factors related to thermal and oxidative DNA damage. In this work, a novel electrochemical DNA sensor has been proposed for the determination of antitumor drugs. For DNA sensor assembling, a glassy carbon electrode was modified with carbon black dispersed in DMF. After that, pillar [5]arene was adsorbed and Methylene blue and Neutral red were consecutively electropolymerized onto the carbon black layer. To increase sensitivity of intercalator detection, DNA was first mixed with water-soluble thiacalixarene bearing quaternary ammonium groups in the substituents at the lower rim. The deposition of the mixture on the electropolymerized dyes made it possible to detect doxorubicin as model intercalator by suppression of the redox activity of the polymerization products. The DNA sensor made it possible to determine 0.5 pM–1.0 nM doxorubicin (limit of detection 0.13 pM) with 20 min of incubation. The DNA sensor was successfully tested on spiked samples of human plasma and doxorubicin medication. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.Russian Foundation for Basic Research, РФФИ: 20-33-90132; Russian Science Foundation, RSF: 19-73-10134Funding: This research was funded by the Russian Science Foundation (PP), grant number 19-73-10134 (synthesis of thiacalix [4]arenes bearing terminal ammonium groups and investigation of their interactions with DNA) and the Russian Foundation for Basic Research (GE), grant No 20-33-90132 (electropolymerization of dyes and assembling of the surface layer of DNA sensor)

Electrochemical Determination of Malathion on an Acetylcholinesterase-Modified Glassy Carbon Electrode

© 2017 Taylor & Francis. An acetylcholinesterase biosensor based on glassy carbon electrode modified with carbon black and pillar[5]arene was used for the determination of malathion after its preliminary oxidation. The contributions of enzyme immobilization and oxidation conditions to the improvement of analytical characteristics of the biosensor were considered and quantified. In optimal conditions, the acetylcholinesterase biosensor allows the determination of 40 pM of malathion with 10 min of incubation and 15 pM with 30 min of incubation. The sensitivity of immobilized enzyme was found to be higher than that the free enzyme due to sorbtional accumulation in the modifier layer. Incomplete oxidation of malathion decreased the sensitivity of the assay. The developed acetylcholinesterase biosensor was validated for the determination of malathion residues in grapes, wine, and peanuts. The recoveries calculated against a high-performance liquid chromatography assay were between 80 and 120% due to possible matrix effects and the simplified extraction protocols

Selective stepwise oxidation of 1,4-decamethoxypillar[5]arene

© The Royal Society of Chemistry and the Centre National de la Recherche Scientifique. For the first time, the 1H and 13C{1H} NMR data were classified and analyzed for the pillar[5]arenes with one, two, three and five 1,4-benzoquinone fragments obtained in good yields. The empirical relationships established make it possible to define the relative position of the quinone and aryl fragments to each other in the oxidation products of any pillar[n]arenes

Synthetic receptors based on calix[4]arene functionalized at the lower rim in molecular recognition of dicarboxylic, α-hydroxycarboxylic, and α-amino acids

New calix[4]arenes, di- and tetrasubstituted at the lower rim, with different functional groups were synthesized. They were studied as carriers of a series of dicarboxylic and α-hydroxycarboxylic acids through a liquid impregnated membrane. The calix[4]arenes under study are capable of molecular recognition of oxalic acid in the series of structurally similar dicarboxylic and α-hydroxycarboxylic acids. The regularities found make it possible to change purposefully the receptor ability of 1,3-disubstituted calix[4]arenes by variation of the nature of substituents

Organic Acid and DNA Sensing with Electrochemical Sensor Based on Carbon Black and Pillar[5]arene

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimElectrochemical sensor has been proposed on the base of glassy carbon electrode (GCE) modified with carbon black (CB) and pillar[5]arene (P[5]A). The characteristics of the peak currents were found to be sensitive to the incubation of the sensor in organic acid and DNA solution. The detection of n×(10−8–10−5) M of organic acid and down to (1–5)×10−18 g of DNA was attributed to the effect of the analytes on the aggregation and relative stability of oxidized and reduced forms of P[5]A. No signal interference with the alkali and alkali-earth metal ions was found. The electrochemical sensor was tested in the detection of specific DNA interactions, i.e. reactive oxygen species damage and intercalating pharmaceuticals detection