8 research outputs found
ΠΠ ΠΠΠΠΠ ΠΠΠΠ’ΠΠΠ¬ΠΠΠ‘Π’Π Π‘ΠΠΠ ΠΠΠΠΠΠ― ΠΠΠ‘Π’Π ΠΠΠ¦ΠΠΠΠΠΠΠ Π ΠΠΠΠΠΠ ΠΠ’Π
Aim of the study the characteristics of changes of serum biochemical parameters in dogs with delayed maturation of the distraction regenerate after surgical lengthening the leg bones by Ilizarov. The comparative analysis of biochemical changes in blood serum of animals with delayed regenerated bone osteogenesis after surgical leg bone lengthening according to Ilizarov has been made in the work. The development of persistent and marked hypocalcemia, significant accumulation of blood serum nonoxidized degradation products during limb bone surgical lengthening according to Ilizarov have been revealed to be adverse signs evidencing of the high probability of the disorder of further formation of the regenerated bone and its subsequent maturation at the stage of fixation.Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ - ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΡ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΡΡΠ²ΠΎΡΠΎΡΠΊΠΈ ΠΊΡΠΎΠ²ΠΈ Ρ ΡΠΎΠ±Π°ΠΊ Ρ Π·Π°ΠΌΠ΅Π΄Π»Π΅Π½Π½ΡΠΌ ΡΠΎΠ·ΡΠ΅Π²Π°Π½ΠΈΠ΅ΠΌ Π΄ΠΈΡΡΡΠ°ΠΊΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠ° ΠΏΠΎΡΠ»Π΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠ΄Π»ΠΈΠ½Π΅Π½ΠΈΡ ΠΊΠΎΡΡΠ΅ΠΉ Π³ΠΎΠ»Π΅Π½ΠΈ ΠΏΠΎ ΠΠ»ΠΈΠ·Π°ΡΠΎΠ²Ρ. Π ΡΠ°Π±ΠΎΡΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ Ρ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Ρ Π·Π°ΠΌΠ΅Π΄Π»Π΅Π½Π½ΡΠΌ ΠΊΠΎΡΡΠ΅ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠ° ΠΏΠΎΡΠ»Π΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠ΄Π»ΠΈΠ½Π΅Π½ΠΈΡ ΠΊΠΎΡΡΠ΅ΠΉ Π³ΠΎΠ»Π΅Π½ΠΈ ΠΏΠΎ ΠΠ»ΠΈΠ·Π°ΡΠΎΠ²Ρ. ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ, ΡΡΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΠΉ ΠΈ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠΉ Π³ΠΈΠΏΠΎΠΊΠ°Π»ΡΡΠΈΠ΅ΠΌΠΈΠΈ, Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅ Π½Π΅ΠΎΠΊΠΈΡΠ»ΡΠ΅ΠΌΡΡ
ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² ΡΠ°ΡΠΏΠ°Π΄Π° Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ Π² Ρ
ΠΎΠ΄Π΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠ΄Π»ΠΈΠ½Π΅Π½ΠΈΡ ΠΊΠΎΡΡΠ΅ΠΉ ΠΊΠΎΠ½Π΅ΡΠ½ΠΎΡΡΠ΅ΠΉ ΠΏΠΎ ΠΠ»ΠΈΠ·Π°ΡΠΎΠ²Ρ ΡΠ²Π»ΡΡΡΡΡ Π½Π΅Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΡΠΌΠΈ ΠΏΡΠΈΠ·Π½Π°ΠΊΠ°ΠΌΠΈ, ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡΠΈΠΌΠΈ ΠΎ Π²ΡΡΠΎΠΊΠΎΠΉ Π²Π΅ΡΠΎΡΡΠ½ΠΎΡΡΠΈ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅Π³ΠΎ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠ° ΠΈ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅Π³ΠΎ Π΅Π³ΠΎ ΡΠΎΠ·ΡΠ΅Π²Π°Π½ΠΈΡ Π½Π° ΡΡΠ°ΠΏΠ΅ ΡΠΈΠΊΡΠ°ΡΠΈΠΈ
ΠΠΎΡΡΠ½ΡΠ΅ ΠΊΡΠ΅Π½ΠΎΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ Π² ΡΡΠ°Π²ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΎΡΡΠΎΠΏΠ΅Π΄ΠΈΠΈ (Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΎΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ)
Purpose of the analytical review β to evaluate the application experience of bone xenografts in trauma and orthopaedics surgery. Methods. Data search was performed in the electronic databases of PubMed and eLIBRARY with depth of 20 years. Results. The authors identified 13 papers which described the application experience of boneΒ xenografts in trauma surgery and orthopaedics. The highest efficiency (from 92 to 100%) was reported for cases of xenografts use to replace defects in intraarticular fractures and revision arthroplasty. Unsatisfactory outcomes were related to cases with no integration and graft rejection. The least efficiency (from 41,9 to 46,1%) was reported in reconstructive foot surgery. No effect of bone xenografts was observed for replacement of defects in cases of pseudoarthrosis. The most frequent complication was graft material infection. The summarized literature data provided the calculated share of complications following xenograft use of 7,53% (18 out of 239 cases, CI 5-95%, 4,53-11,21). Two areas were identified for improvement of technical and biological properties of bone xenografts: 1. Modification of original xeno-matrix (enhancement of purification technique, alteration of structure of chemical composition of the bone matrix); 2. Augmentation of matrix volume by additional elements (biologically active agents, stem cells). Itβs noted that demand for xenografts in traumatology and orthopaedics can increase after refining and expanding the indications for clinical use. Conclusion. Bone xenografts used in the modern trauma surgery and orthopaedics to replace bone defects in revision arthroplasty as well as in certain fracture types. Such material is relatively safe and its ability to be modified allows to improve its biological properties.Π¦Π΅Π»Ρ Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±Π·ΠΎΡΠ° β ΠΎΡΠ΅Π½ΠΈΡΡ ΠΎΠΏΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΠΎΡΡΠ½ΡΡ
ΠΊΡΠ΅Π½ΠΎΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ² Π² ΡΡΠ°Π²ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΎΡΡΠΎΠΏΠ΅Π΄ΠΈΠΈ. ΠΠ΅ΡΠΎΠ΄Ρ. ΠΠΎΠΈΡΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΠ½ΡΡ
ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΎΠ² ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΡΡ Π² ΠΎΡΠΊΡΡΡΡΡ
ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΡΡ
Π±Π°Π·Π°Ρ
Π΄Π°Π½Π½ΡΡ
Π½Π°ΡΡΠ½ΠΎΠΉ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ PubMed ΠΈ eLIBRARY. ΠΠ»ΡΠ±ΠΈΠ½Π° ΠΏΠΎΠΈΡΠΊΠ° β 20 Π»Π΅Ρ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ 13 ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΎΠ², Π² ΠΊΠΎΡΠΎΡΡΡ
ΠΎΠΏΠΈΡΠ°Π½ ΠΎΠΏΡΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΠΎΡΡΠ½ΠΎΠΏΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ² ΠΊΠΎΡΡΠ½ΠΎΠ³ΠΎ ΠΊΡΠ΅Π½ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΠΈΡΡ
ΠΎΠΆΠ΄Π΅Π½ΠΈΡ Π² ΡΡΠ°Π²ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΎΡΡΠΎΠΏΠ΅Π΄ΠΈΠΈ. ΠΡΠΌΠ΅ΡΠ΅Π½ΠΎ, ΡΡΠΎ Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΠ°Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ (ΠΎΡ 92 Π΄ΠΎ 100%) ΠΎΠ±Π½Π°ΡΡΠΆΠΈΠ²Π°Π΅ΡΡΡ Π² ΡΠ»ΡΡΠ°ΡΡ
ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΡΠ΅Π½ΠΎΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° Π΄Π»Ρ Π·Π°ΠΌΠ΅ΡΠ΅Π½ΠΈΡ Π΄Π΅ΡΠ΅ΠΊΡΠΎΠ² ΠΏΡΠΈ Π²Π½ΡΡΡΠΈΡΡΡΡΠ°Π²Π½ΡΡ
ΠΏΠ΅ΡΠ΅Π»ΠΎΠΌΠ°Ρ
ΠΈ ΡΠ΅Π²ΠΈΠ·ΠΈΠΎΠ½Π½ΠΎΠΌ ΡΠ½Π΄ΠΎΠΏΡΠΎΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ. Π‘Π»ΡΡΠ°ΠΈ Π½Π΅ΡΠ΄ΠΎΠ²Π»Π΅ΡΠ²ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΈΡΡ
ΠΎΠ΄ΠΎΠ² ΡΠ²ΡΠ·Π°Π½Ρ Ρ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ΠΌ ΠΈΠ½ΡΠ΅Π³ΡΠ°ΡΠΈΠΈ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° ΠΈ Π΅Π³ΠΎ ΠΎΡΡΠΎΡΠΆΠ΅Π½ΠΈΠ΅ΠΌ. ΠΠ°ΠΈΠΌΠ΅Π½ΡΡΠ°Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ (ΠΎΡ 41,9 Π΄ΠΎ 46,1%) ΠΎΡΠΌΠ΅ΡΠ΅Π½Π° ΠΏΡΠΈ ΡΠ΅ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠ²Π½ΡΡ
ΠΎΠΏΠ΅ΡΠ°ΡΠΈΡΡ
Π½Π° ΡΡΠΎΠΏΠ΅. ΠΡΠΌΠ΅ΡΠ΅Π½ΠΎ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ ΡΡΡΠ΅ΠΊΡΠ° ΠΏΠΎΡΠ»Π΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΡΠ΅Π½ΠΎΠ³Π΅Π½Π½ΡΡ
ΠΊΠΎΡΡΠ½ΡΡ
ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ² Π΄Π»Ρ Π·Π°ΠΌΠ΅ΡΠ΅Π½ΠΈΡ Π΄Π΅ΡΠ΅ΠΊΡΠΎΠ² ΠΏΡΠΈ ΠΏΡΠ΅Π²Π΄ΠΎΠ°ΡΡΡΠΎΠ·Π΅. ΠΡΠ½ΠΎΠ²Π½ΠΎΠ΅ Π²ΡΡΡΠ΅ΡΠ°Π΅ΠΌΠΎΠ΅ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠ΅ β ΠΈΠ½ΡΠΈΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π°. Π Π°ΡΡΠ΅ΡΠ½ΡΠΉ ΠΏΡΠΎΡΠ΅Π½Ρ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ ΠΏΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠΈ ΠΊΡΠ΅Π½ΠΎΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ² ΠΏΠΎΡΠ»Π΅ ΡΡΠΌΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π΄Π°Π½Π½ΡΡ
Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΡΠΎΡΡΠ°Π²ΠΈΠ» 7,53% (18 ΡΠ»ΡΡΠ°Π΅Π² ΠΈΠ· 239, ΠΠ 5β95%: 4,53β11,21). ΠΡΠ΄Π΅Π»Π΅Π½ΠΎ Π΄Π²Π° Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΡΠ»ΡΡΡΠ΅Π½ΠΈΡ ΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊ ΠΊΠΎΡΡΠ½ΡΡ
ΠΊΡΠ΅Π½ΠΎΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ²: 1. ΠΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΈΡΡ
ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΊΡΠ΅Π½ΠΎΠΌΠ°ΡΡΠΈΠΊΡΠ° (ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΎΡΠΈΡΡΠΊΠΈ, ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΡΡΡΠΊΡΡΡΡ ΠΈ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΎΡΡΠ°Π²Π° ΠΌΠ°ΡΡΠΈΠΊΡΠ° ΠΊΠΎΡΡΠΈ); 2. ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ Π² ΠΎΠ±ΡΠ΅ΠΌ ΠΌΠ°ΡΡΠΈΠΊΡΠ° Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² (Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΠ΅ Π²Π΅ΡΠ΅ΡΡΠ²Π°, ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ). ΠΡΠΌΠ΅ΡΠ΅Π½ΠΎ, ΡΡΠΎ ΠΊΡΠ΅Π½ΠΎΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ Π² ΡΡΠ°Π²ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΎΡΡΠΎΠΏΠ΅Π΄ΠΈΠΈ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ Π±ΠΎΠ»Π΅Π΅ Π²ΠΎΡΡΡΠ΅Π±ΠΎΠ²Π°Π½Π½ΡΠΌΠΈ Π·Π° ΡΡΠ΅Ρ ΡΡΠΎΡΠ½Π΅Π½ΠΈΡ ΠΈ ΡΠ°ΡΡΠΈΡΠ΅Π½ΠΈΡ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΈΠΉ ΠΊ ΠΈΡ
ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΡΠ΅Π½ΠΎΠ³Π΅Π½Π½ΡΠΉ ΠΊΠΎΡΡΠ½ΡΠΉ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π» Π² ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ ΡΡΠ°Π²ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΎΡΡΠΎΠΏΠ΅Π΄ΠΈΠΈ Π½Π°ΡΠ΅Π» ΡΠ²ΠΎΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π΄Π»Ρ Π²ΠΎΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΡ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΊΠ° ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΏΡΠΈ ΡΠ΅Π²ΠΈΠ·ΠΈΠΎΠ½Π½ΡΡ
ΠΎΠΏΠ΅ΡΠ°ΡΠΈΡΡ
ΠΏΠΎ ΡΠ½Π΄ΠΎΠΏΡΠΎΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ, Π° ΡΠ°ΠΊΠΆΠ΅ Π΄Π»Ρ Π·Π°ΠΌΠ΅ΡΠ΅Π½ΠΈΡ Π΄Π΅ΡΠ΅ΠΊΡΠΎΠ² ΠΊΠΎΡΡΠΈ ΠΏΡΠΈ Π½Π΅ΠΊΠΎΡΠΎΡΡΡ
Π²ΠΈΠ΄Π°Ρ
ΠΏΠ΅ΡΠ΅Π»ΠΎΠΌΠΎΠ². ΠΡΠΎΡ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ΅Π½, Π° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ Π΅Π³ΠΎ ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΡΠ»ΡΡΡΠ°ΡΡ Π΅Π³ΠΎ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ
Features of physiological processes in migrants and indigenous population of Ugra (Russia)
Amid the climatic and geographic conditions of the Northern territories, the human body, especially from migrants, is influenced by unusual, excessive and harsh environmental factors that are irrelevant to its nature. The current situation shows that the social and economic losses that entail conditions associated with a decrease in the population adaptability, especially non-indigenous, leads to the need not only to study the mechanisms of physiological changes in the residents of the Northern regions, but also to find ways to prevent diseases in the descendants of migrants living in the North of the Russian Federation.En medio de las condiciones climΓ‘ticas y geogrΓ‘ficas de los territorios del norte, el cuerpo humano, especialmente el de los migrantes, estΓ‘ influenciado por factores ambientales inusuales, excesivos y severos que son irrelevantes para su naturaleza. La situaciΓ³n actual muestra que las pΓ©rdidas sociales y econΓ³micas que conllevan condiciones asociadas con una disminuciΓ³n de la adaptabilidad de la poblaciΓ³n, especialmente los no indΓgenas, lleva a la necesidad no solo de estudiar los mecanismos de cambios fisiolΓ³gicos en los residentes de las regiones del norte, sino tambiΓ©n encontrar formas de prevenir enfermedades de los descendientes inmigrantes que viven en el norte de la FederaciΓ³n de Rusia
ΠΠΠΠ ΠΠΠΠΠΠΠ Π Π‘ΠΠΠΠΠ’ΠΠ«Π₯ ΠΠ«Π¨Π¦ΠΠ₯ Π‘ΠΠΠΠ Π Π₯ΠΠΠ ΠΠΠ§ΠΠΠΠ― ΠΠΠ ΠΠΠΠΠ ΠΠΠ‘Π’ΠΠ ΠΠΠΠΠΠ ΠΠ ΠΠΠΠΠΠ ΠΠΠ£
Aim - to study the dynamics of the recovery of energy resources in the tibialis anterior (TA) in dogs after shin fractures. Material and methods. The concentration of energy metabolism substrates, the rate of glycolysis and glycogenolysis in TA in 25 dogs during the treatment of tibial fractures by Ilizarov were studied. The values parameters in the experimental animals were compared with values in the intact (non-operated) dogs. Results. The level of glycogen and glucose decreased in TA within 14 days of fixation. On the 28th day of fixing the level of these metabolites corresponded to the level in intact animals. By the end of fixation the rate of glycogen utilization in TA of experimental animals was significantly reduced relative to intact animals, and the rate of glucose utilization was unchanged, though all glucose was almost entirely utilized by aerobic way. A month after treatment there was an increase of glycogen levels in the TA and activity of lactatedehydrogenase MM-isoenzyme. When glycogen solution added to the cell-free culture of muscle the its considerable utilization and the pyruvate accumulation were found. Conclusions. Anaerobic energy metabolism of in the TA of injured segment have prevailed before the 14-th day after the injury, the aerobic energy metabolism - after 28-days. The phenomenon of growth of anaerobic energy metabolism in TA of injured segment within three months after treatment was revealed.Π¦Π΅Π»Ρ - ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΡ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΡ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ ΡΠ½Π΅ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅ΡΡΡΡΠΎΠ² Π² ΠΏΠ΅ΡΠ΅Π΄Π½Π΅ΠΉ Π±ΠΎΠ»ΡΡΠ΅Π±Π΅ΡΡΠΎΠ²ΠΎΠΉ ΠΌΡΡΡΠ΅ (ΠΠΠΠ) ΡΠΎΠ±Π°ΠΊ ΠΏΠΎΡΠ»Π΅ ΠΏΠ΅ΡΠ΅Π»ΠΎΠΌΠ° ΠΊΠΎΡΡΠ΅ΠΉ Π³ΠΎΠ»Π΅Π½ΠΈ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ·ΡΡΠ΅Π½Ρ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡ ΡΡΠ±ΡΡΡΠ°ΡΠΎΠ² ΡΠ½Π΅ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π°, ΡΠΊΠΎΡΠΎΡΡΡ Π³Π»ΠΈΠΊΠΎΠ»ΠΈΠ·Π° ΠΈ Π³Π»ΠΈΠΊΠΎΠ³Π΅Π½ΠΎΠ»ΠΈΠ·Π° Π² ΠΠΠΠ Ρ 25 ΡΠΎΠ±Π°ΠΊ ΠΏΡΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΠΏΠ΅ΡΠ΅Π»ΠΎΠΌΠ° ΠΊΠΎΡΡΠ΅ΠΉ Π³ΠΎΠ»Π΅Π½ΠΈ ΠΏΠΎ ΠΠ»ΠΈΠ·Π°ΡΠΎΠ²Ρ ΠΠ½Π°ΡΠ΅Π½ΠΈΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
ΡΡΠ°Π²Π½ΠΈΠ²Π°Π»ΠΈ Ρ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ ΠΈΠ½ΡΠ°ΠΊΡΠ½ΡΡ
(Π½Π΅ΠΎΠΏΠ΅ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
) ΡΠΎΠ±Π°ΠΊ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π ΠΠΠΠ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 14 ΡΡΡΠΎΠΊ ΡΠΈΠΊΡΠ°ΡΠΈΠΈ ΡΠ½ΠΈΠΆΠ°Π»ΡΡ ΡΡΠΎΠ²Π΅Π½Ρ Π³Π»ΠΈΠΊΠΎΠ³Π΅Π½Π° ΠΈ Π³Π»ΡΠΊΠΎΠ·Ρ. ΠΠ° 28-Π΅ ΡΡΡΠΊΠΈ ΡΠΈΠΊΡΠ°ΡΠΈΠΈ ΡΡΠΎΠ²Π΅Π½Ρ ΡΡΠΈΡ
ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠΎΠ² ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΎΠ²Π°Π» ΡΡΠΎΠ²Π½Ρ ΠΈΠ½ΡΠ°ΠΊΡΠ½ΡΡ
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
. Π ΠΊΠΎΠ½ΡΡ ΡΠΈΠΊΡΠ°ΡΠΈΠΈ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ, ΡΡΠΎ ΡΠΊΠΎΡΠΎΡΡΡ ΡΡΠΈΠ»ΠΈΠ·Π°ΡΠΈΠΈ Π³Π»ΠΈΠΊΠΎΠ³Π΅Π½Π° Π² ΠΠΠΠ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Π±ΡΠ»Π° Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ ΡΠ½ΠΈΠΆΠ΅Π½Π° ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΈΠ½ΡΠ°ΠΊΡΠ½ΡΡ
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
, Π° ΡΠΊΠΎΡΠΎΡΡΡ ΡΡΠΈΠ»ΠΈΠ·Π°ΡΠΈΠΈ Π³Π»ΡΠΊΠΎΠ·Ρ Π½Π΅ ΠΈΠ·ΠΌΠ΅Π½ΡΠ»Π°ΡΡ, ΠΏΡΠΈ ΡΡΠΎΠΌ Π²ΡΡ Π³Π»ΡΠΊΠΎΠ·Π° ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ ΠΏΠΎΠ»Π½ΠΎΡΡΡΡ ΡΡΠΈΠ»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π»Π°ΡΡ ΠΏΠΎ Π°ΡΡΠΎΠ±Π½ΠΎΠΌΡ ΠΏΡΡΠΈ. Π§Π΅ΡΠ΅Π· ΠΌΠ΅ΡΡΡ ΠΏΠΎΡΠ»Π΅ ΠΎΠΊΠΎΠ½ΡΠ°Π½ΠΈΡ Π»Π΅ΡΠ΅Π½ΠΈΡ Π² ΠΠΠΠ ΠΎΡΠΌΠ΅ΡΠ°Π»ΡΡ ΡΠΎΡΡ ΡΡΠΎΠ²Π½Ρ Π³Π»ΠΈΠΊΠΎΠ³Π΅Π½Π° ΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΠ-ΠΈΠ·ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ° Π»Π°ΠΊΡΠ°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π·Ρ. ΠΡΠΈ Π΄ΠΎΠ±Π°Π²Π»Π΅Π½ΠΈΠΈ Π² Π±Π΅ΡΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΠΊΡΠ»ΡΡΡΡΡ ΠΌΡΡΡ ΡΠ°ΡΡΠ²ΠΎΡΠ° Π³Π»ΠΈΠΊΠΎΠ³Π΅Π½Π° ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Π° Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½Π°Ρ Π΅Π³ΠΎ ΡΡΠΈΠ»ΠΈΠ·Π°ΡΠΈΡ ΠΈ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅ ΠΏΠΈΡΡΠ²Π°ΡΠ°. ΠΡΠ²ΠΎΠ΄Ρ. ΠΠ½Π°ΡΡΠΎΠ±Π½ΡΠΉ ΡΠ½Π΅ΡΠ³ΠΎΠΎΠ±ΠΌΠ΅Π½ Π² ΠΠΠΠ ΡΡΠ°Π²ΠΌΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΡΠ΅Π³ΠΌΠ΅Π½ΡΠ° ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π» Π΄ΠΎ 14-Ρ
ΡΡΡΠΎΠΊ ΠΏΠΎΡΠ»Π΅ ΡΡΠ°Π²ΠΌΡ, Π°ΡΡΠΎΠ±Π½ΡΠΉ - ΠΏΠΎΡΠ»Π΅ 28-Ρ
ΡΡΡΠΎΠΊ. ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½ ΡΠ΅Π½ΠΎΠΌΠ΅Π½ ΡΠΎΡΡΠ° Π°Π½Π°ΡΡΠΎΠ±Π½ΠΎΠ³ΠΎ ΡΠ½Π΅ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° ΠΠΠΠ ΡΡΠ°Π²ΠΌΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΡΠ΅Π³ΠΌΠ΅Π½ΡΠ° Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΡΡΠ΅Ρ
ΠΌΠ΅ΡΡΡΠ΅Π² ΠΏΠΎΡΠ»Π΅ Π»Π΅ΡΠ΅Π½ΠΈΡ
ΠΠΠ ΠΠΠ ΠΠΠΠ«Π Π ΠΠΠ£ΠΠ―Π’ΠΠ Π« ΠΠΠ‘Π’Π ΠΠΠ¦ΠΠΠΠΠΠΠ ΠΠ‘Π’ΠΠΠΠΠΠΠΠ (ΠΏΠΈΠ»ΠΎΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅)
Purpose β to evaluate effect of protein extracted from lengthened skeletal muscles on callus formation in dogs afterΒ tibia lengthening using Ilizarov method.Materials and methods. The authors studied properties of distraction callus formation in three groups of dogs afterΒ tibia lengthening by Ilizarov method. In the first group (n = 10) distraction was achieved at a rate of 1 mm in fourΒ stages during 28 days. In the second (n = 4) and third (n = 4) groups distraction was done at a rate of 1.5 mm in 6 stagesΒ per day within 20 days. Mean lengthening value in all groups amounted to 14,64Β±0,67% of the overall segment length.Β At the 10th day of distraction the authors introduced to animals of the second group into anterior tibial and gastrocnemiusΒ muscles of the lengthened segment at callus level the extract of sarcoplasmic proteins in amount of 1.5ml based on 1 mgΒ of lyophilizate per 1 kg of body weight (protein concentration in injectate amounted to 30Β±2 gr/l). Animals in the thirdΒ group received natural saline solution in the same manner.Β Extract consisted of lyophilized sarcoplasmic proteins harvested from anterior tibial muscle of animal at 14th dayΒ of lengthening by Ilizarov method (rate of 1 mm per day in 4 stages). Extraction was performed according to patentedΒ method (Russian Federation patent for invention β2476234) by consecutive muscle proteins sedimentation in KClΒ solutions of varied ionic strength. The lyophilizate was sterilized after obtaining and dissolved in normal saline solutionΒ prior to introduction.Results. Radiographic signs of anatomically solid callus in the first group were observed in the average at 33Β±1 day ofΒ fixation; in the second group β at 24Β±2 day; in the third group β at 39Β±3. Difference in mean values of fixation in animalsΒ of second group as compared to first and third groups was significant (Ρ = 0,04). After extract introduction the animals ofΒ the second group demonstrated a greater growth of Ξ³-globulins and Ξ±2-globulins fraction volumes.Conclusion. Skeletal muscles of limb segment lengthened by Ilizarov method produce specific factors that impact theΒ process of distraction osteogenesis.Π¦Π΅Π»Ρ β ΠΎΡΠ΅Π½ΠΈΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π±Π΅Π»ΠΊΠΎΠ²ΠΎΠ³ΠΎ ΡΠΊΡΡΡΠ°ΠΊΡΠ°, Π²ΡΠ΄Π΅Π»Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈΠ· ΡΠ΄Π»ΠΈΠ½ΡΠ΅ΠΌΡΡ
ΡΠΊΠ΅Π»Π΅ΡΠ½ΡΡ
ΠΌΡΡΡ, Π½Π° ΠΏΡΠΎΡΠ΅ΡΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π΄ΠΈΡΡΡΠ°ΠΊΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠ° Ρ ΡΠΎΠ±Π°ΠΊ ΠΏΡΠΈ ΡΠ΄Π»ΠΈΠ½Π΅Π½ΠΈΠΈ ΠΊΠΎΡΡΠ΅ΠΉ Π³ΠΎΠ»Π΅Π½ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΠ»ΠΈΠ·Π°ΡΠΎΠ²Π°.ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ·ΡΡΠ΅Π½Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π΄ΠΈΡΡΡΠ°ΠΊΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠ° Ρ ΡΠΎΠ±Π°ΠΊ ΡΡΠ΅Ρ
Π³ΡΡΠΏΠΏΒ ΠΏΡΠΈ ΡΠ΄Π»ΠΈΠ½Π΅Π½ΠΈΠΈ ΠΊΠΎΡΡΠ΅ΠΉ Π³ΠΎΠ»Π΅Π½ΠΈ ΠΏΠΎ ΠΠ»ΠΈΠ·Π°ΡΠΎΠ²Ρ. Π ΠΏΠ΅ΡΠ²ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ (n = 10) Π΄ΠΈΡΡΡΠ°ΠΊΡΠΈΡ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ»ΠΈ Π² ΡΠ΅ΠΆΠΈΠΌΠ΅ 1 ΠΌΠΌΒ Π·Π° 4 ΠΏΡΠΈΠ΅ΠΌΠ° Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 28 ΡΡΡΠΎΠΊ. ΠΠΎ Π²ΡΠΎΡΠΎΠΉ (n = 4) ΠΈ ΡΡΠ΅ΡΡΠ΅ΠΉ (n = 4) Π³ΡΡΠΏΠΏΠ°Ρ
Π΄ΠΈΡΡΡΠ°ΠΊΡΠΈΡ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ»ΠΈ Π² ΡΠ΅ΠΆΠΈΠΌΠ΅Β 1,5 ΠΌΠΌ Π·Π° 6 ΠΏΡΠΈΠ΅ΠΌΠΎΠ² Π² ΡΡΡΠΊΠΈ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 20 ΡΡΡΠΎΠΊ. ΠΠΎ Π²ΡΠ΅Ρ
Π³ΡΡΠΏΠΏΠ°Ρ
Π²Π΅Π»ΠΈΡΠΈΠ½Π° ΡΠ΄Π»ΠΈΠ½Π΅Π½ΠΈΡ Π² ΡΡΠ΅Π΄Π½Π΅ΠΌ ΡΠΎΡΡΠ°Π²ΠΈΠ»Π°Β 14,64Β±0,67% ΠΎΡ ΠΎΠ±ΡΠ΅ΠΉ Π΄Π»ΠΈΠ½Ρ ΡΠ΅Π³ΠΌΠ΅Π½ΡΠ°. ΠΠ° 10-Π΅ ΡΡΡΠΊΠΈ Π΄ΠΈΡΡΡΠ°ΠΊΡΠΈΠΈ ΡΠΎΠ±Π°ΠΊΠ°ΠΌ Π²ΡΠΎΡΠΎΠΉ Π³ΡΡΠΏΠΏΡ Π² ΠΏΠ΅ΡΠ΅Π΄Π½ΡΡ Π±ΠΎΠ»ΡΡΠ΅Π±Π΅ΡΡΠΎΠ²ΡΡ ΠΈ ΠΈΠΊΡΠΎΠ½ΠΎΠΆΠ½ΡΡ ΠΌΡΡΡΡ ΡΠ΄Π»ΠΈΠ½ΡΠ΅ΠΌΠΎΠ³ΠΎ ΡΠ΅Π³ΠΌΠ΅Π½ΡΠ° Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ ΡΠΊΡΡΡΠ°ΠΊΡ ΡΠ΅ΡΡΠΈΡΡΠ΅ΠΌΡΡ
ΡΠ°ΡΠΊΠΎΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π±Π΅Π»ΠΊΠΎΠ²,Β ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΠΈΠ· ΠΏΠ΅ΡΠ΅Π΄Π½Π΅ΠΉ Π±ΠΎΠ»ΡΡΠ΅Π±Π΅ΡΡΠΎΠ²ΠΎΠΉ ΠΌΡΡΡΡ ΡΠΎΠ±Π°ΠΊΠΈ Π½Π° 14-Π΅ ΡΡΡΠΊΠΈ Π΄ΠΈΡΡΡΠ°ΠΊΡΠΈΠΈ. ΠΠΈΠ²ΠΎΡΠ½ΡΠΌ ΡΡΠ΅ΡΡΠ΅ΠΉ Π³ΡΡΠΏΠΏΡ ΠΏΠΎΒ ΡΠΎΠΉ ΠΆΠ΅ ΡΡ
Π΅ΠΌΠ΅ Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠ°ΡΡΠ²ΠΎΡ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π Π΅Π½ΡΠ³Π΅Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π°Π½Π°ΡΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈ ΡΠΎΡΡΠΎΡΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠ° Π² ΠΏΠ΅ΡΠ²ΠΎΠΉΒ Π³ΡΡΠΏΠΏΠ΅ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈΡΡ Π² ΡΡΠ΅Π΄Π½Π΅ΠΌ Π½Π° 33Β±1 ΡΡΡΠΊΠΈ ΡΠΈΠΊΡΠ°ΡΠΈΠΈ, Π²ΠΎ Π²ΡΠΎΡΠΎΠΉ β Π½Π° 24Β±2, Π² ΡΡΠ΅ΡΡΠ΅ΠΉ β Π½Π° 39Β±3 ΡΡΡΠΊΠΈ. Π Π°Π·Π»ΠΈΡΠΈΡΒ ΡΡΠ΅Π΄Π½ΠΈΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΡΠΈΠΊΡΠ°ΡΠΈΠΈ ΡΠΎΠ±Π°ΠΊ Π²ΡΠΎΡΠΎΠΉ Π³ΡΡΠΏΠΏΡ Ρ ΠΆΠΈΠ²ΠΎΡΠ½ΡΠΌΠΈ ΠΏΠ΅ΡΠ²ΠΎΠΉ ΠΈ ΡΡΠ΅ΡΡΠ΅ΠΉ Π³ΡΡΠΏΠΏ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½Ρ ΠΏΡΠΈ ΡΡΠΎΠ²Π½Π΅ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΠΈ Ρ = 0,04. Π£ ΡΠΎΠ±Π°ΠΊ Π²ΡΠΎΡΠΎΠΉ Π³ΡΡΠΏΠΏΡ ΠΏΠΎΡΠ»Π΅ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° Π±ΡΠ» Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠ°ΠΆΠ΅Π½ ΡΠΎΡΡ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡΒ Ξ³-Π³Π»ΠΎΠ±ΡΠ»ΠΈΠ½ΠΎΠ² ΠΈ Ξ±2-Π³Π»ΠΎΠ±ΡΠ»ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΡΡΠ°ΠΊΡΠΈΠΈ Π±Π΅Π»ΠΊΠΎΠ² ΡΡΠ²ΠΎΡΠΎΡΠΊΠΈ ΠΊΡΠΎΠ²ΠΈ.ΠΡΠ²ΠΎΠ΄Ρ. Π‘ΠΊΠ΅Π»Π΅ΡΠ½ΡΠ΅ ΠΌΡΡΡΡ ΡΠ΅Π³ΠΌΠ΅Π½ΡΠ° ΠΊΠΎΠ½Π΅ΡΠ½ΠΎΡΡΠΈ, ΡΠ΄Π»ΠΈΠ½ΡΠ΅ΠΌΠΎΠ³ΠΎ c ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΠΌΠ΅ΡΠΎΠ΄Π° ΠΠ»ΠΈΠ·Π°ΡΠΎΠ²Π°, ΠΏΡΠΎΠ΄ΡΡΠΈΡΡΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΡΠ΅ ΡΠ°ΠΊΡΠΎΡΡ, Π²Π»ΠΈΡΡΡΠΈΠ΅ Π½Π° ΠΏΡΠΎΡΠ΅ΡΡ Π΄ΠΈΡΡΡΠ°ΠΊΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΎΡΡΠ΅ΠΎΠ³Π΅Π½Π΅Π·Π°
Π‘ΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΎΡΡΠ΅ΠΎΠΈΠ½ΡΠ΅Π³ΡΠ°ΡΠΈΠΈ ΠΈΠ·Π³ΠΎΡΠΎΠ²Π»Π΅Π½Π½ΡΡ Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ Π°Π΄Π΄ΠΈΡΠΈΠ²Π½ΡΡ ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ ΡΠΈΡΠ°Π½ΠΎΠ²ΡΡ ΠΈ ΡΡΠ°Π»ΡΠ½ΡΡ ΠΈΠΌΠΏΠ»Π°Π½ΡΠ°ΡΠΎΠ² Π² Π±ΠΎΠ»ΡΡΠ΅Π±Π΅ΡΡΠΎΠ²ΠΎΠΉ ΠΊΠΎΡΡΠΈ ΠΊΡΠΎΠ»ΠΈΠΊΠ° Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ Π²Π½Π΅ΡΠ½Π΅ΠΉ ΡΠΈΠΊΡΠ°ΡΠΈΠΈ
Relevance. The main goals of successful prosthesis remain ensuring the osseointegration and infectious safety of implants.The purpose of the study β the comparative analysis of osseointegration of titanium and steel additive manufactured implants in the rabbit tibia under additional fixation by Ilizarov apparatus.Materials and Methods. The study was performed on 20 chinchilla male rabbits. The animals of the first group (n = 8 ) were implanted a stainless steel product EOS PH1 (EOS, Germany), the animals of the second group (n = 12) β a titanium alloy Ti6Al4V product. The implant was additionally fixed by Ilizarov apparatus. The implants were processed with additive technology by selective laser fusion at the EOSINT M 280 installation (EOS, Germany). The survival and safety of the implants were assessed using clinical, histological, laboratory and statistical methods.Results. The implant fall due to chronic inflammation was found in 2 animals of group 1 and none in group 2. The formation of weakly mineralized bone tissue on the surface of the implant was noted in 3 weeks in all cases. The bone became more mineralized by the 12th week of the experiment. However, in group 2, the calcium content and Ca / P ratio of the newly formed bone tissue at the 3rd and 12th week after implantation were significantly higher than in the animals of group 1. This indicated the greater maturity of the bone tissue in animals of group 2 at all stages of the experiment. In group 1, the compact plate osteoporosis and calcium-phosphorus balance disturbance were greater.Conclusion. The results of the study indicate that the survival rate (osseointegration) and safety of the product made of the titanium alloy were higher compared with the stainless steel product.ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ. ΠΡΠ½ΠΎΠ²Π½ΡΠΌΠΈ Π·Π°Π΄Π°ΡΠ°ΠΌΠΈ ΡΡΠΏΠ΅ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΎΡΡΠ°ΡΡΡΡ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΎΡΡΠ΅ΠΎΠΈΠ½ΡΠ΅Π³ΡΠ°ΡΠΈΠΈ ΠΈ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΠΎΠΉ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ ΠΈΠΌΠΏΠ»Π°Π½ΡΠ°ΡΠΎΠ².Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΎΡΡΠ΅ΠΎΠΈΠ½ΡΠ΅Π³ΡΠ°ΡΠΈΠΈ ΠΈΠ·Π³ΠΎΡΠΎΠ²Π»Π΅Π½Π½ΡΡ
Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ Π°Π΄Π΄ΠΈΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΡΠΈΡΠ°Π½ΠΎΠ²ΡΡ
ΠΈ ΡΡΠ°Π»ΡΠ½ΡΡ
ΠΈΠΌΠΏΠ»Π°Π½ΡΠ°ΡΠΎΠ² Π² Π±ΠΎΠ»ΡΡΠ΅Π±Π΅ΡΡΠΎΠ²ΠΎΠΉ ΠΊΠΎΡΡΠΈ ΠΊΡΠΎΠ»ΠΈΠΊΠ° Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΈΠΊΡΠ°ΡΠΈΠΈ Π±ΠΈΠΎΠΌΠ΅Ρ
Π°Π½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Π°ΠΏΠΏΠ°ΡΠ°ΡΠΎΠΌ ΠΠ»ΠΈΠ·Π°ΡΠΎΠ²Π°.ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΎ Π½Π° 20 ΠΊΡΠΎΠ»ΠΈΠΊΠ°Ρ
-ΡΠ°ΠΌΡΠ°Ρ
ΠΏΠΎΡΠΎΠ΄Ρ Π¨ΠΈΠ½ΡΠΈΠ»Π»Π°. ΠΠΈΠ²ΠΎΡΠ½ΡΠΌ ΠΏΠ΅ΡΠ²ΠΎΠΉ Π³ΡΡΠΏΠΏΡ (n = 8) ΠΈΠΌΠΏΠ»Π°Π½ΡΠΈΡΠΎΠ²Π°Π»ΠΈ ΠΈΠ·Π΄Π΅Π»ΠΈΠ΅ ΠΈΠ· Π½Π΅ΡΠΆΠ°Π²Π΅ΡΡΠ΅ΠΉ ΡΡΠ°Π»ΠΈ ΠΌΠ°ΡΠΊΠΈ EOS PH1 (EOS, ΠΠ΅ΡΠΌΠ°Π½ΠΈΡ), ΠΆΠΈΠ²ΠΎΡΠ½ΡΠΌ Π²ΡΠΎΡΠΎΠΉ Π³ΡΡΠΏΠΏΡ (n = 12) β ΠΈΠ· ΡΠΈΡΠ°Π½ΠΎΠ²ΠΎΠ³ΠΎ ΡΠΏΠ»Π°Π²Π° ΠΌΠ°ΡΠΊΠΈ Ti6Al4V. ΠΠΌΠΏΠ»Π°Π½ΡΠ°Ρ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠΈΠΊΡΠΈΡΠΎΠ²Π°Π»ΠΈ Π°ΠΏΠΏΠ°ΡΠ°ΡΠΎΠΌ ΠΠ»ΠΈΠ·Π°ΡΠΎΠ²Π°. ΠΠΌΠΏΠ»Π°Π½ΡΠ°ΡΡ Π±ΡΠ»ΠΈ ΠΈΠ·Π³ΠΎΡΠΎΠ²Π»Π΅Π½Ρ Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ Π°Π΄Π΄ΠΈΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π»Π°Π·Π΅ΡΠ½ΠΎΠ³ΠΎ ΡΠΏΠ»Π°Π²Π»Π΅Π½ΠΈΡ Π½Π° ΡΡΡΠ°Π½ΠΎΠ²ΠΊΠ΅ EOSINT M 280 (EOS, ΠΠ΅ΡΠΌΠ°Π½ΠΈΡ). ΠΡΠ΅Π½ΠΊΡ ΠΏΡΠΈΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΠΈ ΠΈ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΈΠΌΠΏΠ»Π°Π½ΡΠ°ΡΠΎΠ² ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ, Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ, Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΈ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π£ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Π³ΡΡΠΏΠΏΡ 1 Π±ΡΠ»ΠΎ Π·Π°ΡΠΈΠΊΡΠΈΡΠΎΠ²Π°Π½ΠΎ Π΄Π²Π° ΡΠ»ΡΡΠ°Ρ Π²ΡΠΏΠ°Π΄Π΅Π½ΠΈΡ ΠΈΠΌΠΏΠ»Π°Π½ΡΠ°ΡΠ° ΠΏΠΎ ΠΏΡΠΈΡΠΈΠ½Π΅ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΡ, Π² Π³ΡΡΠΏΠΏΠ΅ 2 ΡΠ°ΠΊΠΈΡ
ΡΠ»ΡΡΠ°Π΅Π² ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ Π½Π΅ Π±ΡΠ»ΠΎ. ΠΠΎ Π²ΡΠ΅Ρ
ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Ρ
ΡΠ΅ΡΠ΅Π· 3 Π½Π΅Π΄. ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ»Π°Π±ΠΎΠΌΠΈΠ½Π΅ΡΠ°Π»ΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ Π½Π° ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ ΠΈΠΌΠΏΠ»Π°Π½ΡΠ°ΡΠ°, ΠΊΠΎΡΠΎΡΠ°Ρ ΡΡΠ°Π½ΠΎΠ²ΠΈΠ»Π°ΡΡ Π±ΠΎΠ»Π΅Π΅ ΠΌΠΈΠ½Π΅ΡΠ°Π»ΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΊ 12-ΠΉ Π½Π΅Π΄. ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°. ΠΠ΄Π½Π°ΠΊΠΎ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΠΊΠ°Π»ΡΡΠΈΡ ΠΈ ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅ Π‘Π°/Π Π² Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ Π² Π³ΡΡΠΏΠΏΠ΅ 2 Π½Π° 3-ΠΉ ΠΈ 12-ΠΉ Π½Π΅Π΄. ΠΏΠΎΡΠ»Π΅ ΠΈΠΌΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ Π±ΡΠ»ΠΎ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎ Π²ΡΡΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Π³ΡΡΠΏΠΏΡ 1, ΡΡΠΎ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΠΎΠ²Π°Π»ΠΎ ΠΎ Π±ΠΎΠ»ΡΡΠ΅ΠΉ Π·ΡΠ΅Π»ΠΎΡΡΠΈ ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ Ρ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Π³ΡΡΠΏΠΏΡ 2 Π½Π° Π²ΡΠ΅Ρ
ΡΡΠ°ΠΏΠ°Ρ
ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°. Π Π³ΡΡΠΏΠΏΠ΅ 1 ΠΎΡΠΌΠ΅ΡΠ°Π»ΠΈ Π±ΠΎΠ»ΡΡΡΡ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡ ΠΎΡΡΠ΅ΠΎΠΏΠΎΡΠΎΠ·Π° ΠΊΠΎΠΌΠΏΠ°ΠΊΡΠ½ΠΎΠΉ ΠΏΠ»Π°ΡΡΠΈΠ½ΠΊΠΈ ΠΈ Π±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ Π½Π°ΡΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠ°Π»ΡΡΠΈΠΉ-ΡΠΎΡΡΠΎΡΠ½ΠΎΠ³ΠΎ Π±Π°Π»Π°Π½ΡΠ°.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ Π·Π°ΠΊΠ»ΡΡΠΈΡΡ, ΡΡΠΎ ΠΏΡΠΈΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΡ (ΠΎΡΡΠ΅ΠΎΠΈΠ½ΡΠ΅Π³ΡΠ°ΡΠΈΡ) ΠΈ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΡ ΠΈΠ·Π΄Π΅Π»ΠΈΡ, Π²ΡΠΏΠΎΠ»Π½Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈΠ· ΡΠΈΡΠ°Π½ΠΎΠ²ΠΎΠ³ΠΎ ΡΠΏΠ»Π°Π²Π°, Π±ΡΠ»Π° Π²ΡΡΠ΅ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΈΠ·Π΄Π΅Π»ΠΈΠ΅ΠΌ ΠΈΠ· Π½Π΅ΡΠΆΠ°Π²Π΅ΡΡΠ΅ΠΉ ΡΡΠ°Π»ΠΈ