The biologic effect of the studied single nucleotide polymorphism (SNP) and odds ratios (OR) for polymorphisms which have been shown to be associated with risk of Crohn's disease (CD), ulcerative colitis (UC) or inflammatory bowel disease (IBD) in previous studies and in this study.

A<p>Crude (unadjusted).</p>B<p>Adjusted for age, gender and smoking status.</p>C<p>Function examined by flow cytometry.</p>D<p>Function examined by luciferase reporter assay.</p>E<p>Function examined by enzyme-linked immunosorbent assay (ELISA).</p>F<p>Function examined by reverse transcriptase PCR (RT-PCR).</p>G<p>Function examined by electrophoretic mobility shift assay (EMSA).</p><p>ND: not determined.</p

Sixteen functional single nucleotide polymorphisms (SNPs) in 13 genes involved in regulation of inflammation were found to be associated with susceptability of severe Crohn's disease (CD), ulcerative colitis (UC) or inflammatory bowel diseases (IBD).

<p>Eleven of the SNPs have not previously been reported as susceptability polymorphisms of CD, UC or IBD (<i>TLR2</i> (rs4696480 and rs1816702), <i>TLR4</i> (rs1554973 and rs12377632), <i>TLR9</i> (rs187084 and rs352139), <i>LY96</i> (rs11465996), <i>NFKBIA</i> (rs696), <i>TNFRSF1A</i> (rs4149570), <i>IL6R</i> (rs4537545) and <i>PTPN22</i> (rs2476601)).</p

Description of the study participants.

<p>Description of the study participants.</p